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Calcium Pyrophosphate

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An inorganic pyrophosphate which affects calcium metabolism in mammals. Abnormalities in its metabolism occur in some human diseases, notably HYPOPHOSPHATASIA and pseudogout (CHONDROCALCINOSIS).

Also Known As:

Calcium Pyrophosphate (1:1); Calcium Pyrophosphate (1:2); Calcium Pyrophosphate (2:1); Calcium Pyrophosphate Dihydrate; Calcium Pyrophosphate, Monohydrate; Diphosphate, Calcium; Monohydrate Calcium Pyrophosphate; Pyrophosphate Dihydrate, Calcium; Pyrophosphate, Calcium; Pyrophosphate, Monohydrate Calcium; Calcium Diphosphate; Diphosphoric acid, calcium salt

Networked: 525 relevant articles (5 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Phosphorus Compounds: 84
  - Phosphorus Acids: 1
    - Phosphoric Acids: 3
      - Phosphates: 1226
        Polyphosphates: 112
        Diphosphates: 62
        Calcium Pyrophosphate: 525
        sintered beta-dicalcium pyrophosphate
        Calcium Phosphates: 53
        Calcium Pyrophosphate: 525
        sintered beta-dicalcium pyrophosphate
- Calcium Compounds: 14
  - Calcium Phosphates: 53
    - Calcium Pyrophosphate: 525
      - sintered beta-dicalcium pyrophosphate

Experts

1.	Rosenthal, Ann K: 7 articles (03/2015 - 03/2002)
2.	Lioté, Frédéric: 7 articles (01/2013 - 07/2005)
3.	Punzi, L: 5 articles (02/2015 - 07/2005)
4.	Pascual, Eliseo: 5 articles (01/2015 - 06/2005)
5.	Doherty, Michael: 5 articles (05/2014 - 04/2009)
6.	Richette, Pascal: 5 articles (01/2014 - 12/2005)
7.	Pascual, E: 5 articles (04/2011 - 04/2005)
8.	Grassi, Walter: 4 articles (03/2015 - 12/2012)
9.	Filippucci, Emilio: 4 articles (03/2015 - 12/2012)
10.	Oliviero, F: 4 articles (02/2015 - 07/2005)

Related Diseases

1.	Arthritis (Polyarthritis) 01/01/2015 - "Chronic calcium pyrophosphate crystal arthritis is a clinical consequence of the formation and deposition of these crystals in joints and can result in persistent arthritis. " 09/01/2012 - "She was diagnosed to have chronic calcium pyrophosphate crystal arthritis. " 01/01/2012 - "Calcium pyrophosphate crystals are related to a variety of articular manifestations known as calcium pyrophosphate deposition (CPPD) arthritis. " 01/01/2012 - "The forgotten crystal arthritis: calcium pyrophosphate deposition." 05/01/2011 - "Crystal arthritis: calcium pyrophosphate deposition-nothing 'pseudo' about it!"
2.	Gout 09/01/2013 - "Eighty-eight patients with a crystal proven diagnosis of gout or calcium pyrophosphate dihydrate (CPPD) disease attending the in-patient and the out-patient clinics of four Italian Rheumatology Departments were consecutively enrolled in this multi-centre study. " 09/01/2015 - "Dual-Energy Computed Tomography Demonstrating Destructive Calcium Pyrophosphate Deposition Disease of the Distal Radioulnar Joint Mimicking Tophaceous Gout." 05/01/2015 - "[Gout and and calcium pyrophosphate crystal arthropathies: pathophysiology]." 03/01/2015 - "Differentiating gout, calcium pyrophosphate deposition disease (CPPD), and non-crystal-related inflammatory arthropathies (non-CRA) is essential but often clinically impossible. " 03/01/2015 - "In the latest recommendations for the diagnosis and management of gout and calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, the diagnostic potential of ultrasound has been recognized. "
3.	Dental Caries (White Spot) 01/01/1980 - "Effect on dental caries of a stannous fluoride-calcium pyrophosphate dentrifice in an adult population: one-year results." 06/01/1958 - "The effect of a modified stannous fluoride-calcium pyrophosphate dentifrice on dental caries in children." 01/01/1982 - "One comparison showed that particular sodium fluoride/silica and stannous fluoride/calcium pyrophosphate formulations were effective in reducing the incidence of dental caries in schoolchildren and that the former toothpaste was more effective than the latter. "
4.	Osteoarthritis 05/01/2013 - "The aim of this study was to investigate whether calcium pyrophosphate dihydrate (CPPD) crystals are constantly detectable in sequential synovial fluid (SF) examinations of patients with initially CPPD-positive osteoarthritis (OA). " 01/01/2001 - "The aim of this study was to determine the value of scaphoidtrapezium osteoarthritis (ST osteoarthritis) as an early sign of calcium pyrophosphate dihydrate disease (CPDD) in a cohort of patients undergoing surgery for osteoarthritis of the first carpometacarpal joint. " 03/01/1990 - "This study included (a) 50 consecutive patients with osteoarthritis of the knee in whom routine and specialized projections were obtained prospectively, (b) 25 patients with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease whose knee radiographs were retrospectively reviewed, and (c) four cadaveric knees that were dissected to assess pertinent anatomy. " 07/01/2014 - "We sought to determine the prevalence of sternoclavicular (SC) joint calcium pyrophosphate dihydrate (CPPD) crystal deposition and its association with age, osteoarthritis, and atlantoaxial CPPD crystal deposition. " 05/01/2014 - "Calcium pyrophosphate crystal deposition (CPPD) is common and mainly associates with increasing age and osteoarthritis (OA). "
5.	Pleurisy (Pleuritis) 01/01/1987 - "Sequential study of pleural peritoneal and blood cells in acute pleurisy induced by calcium pyrophosphate in the rat." 03/01/2004 - "PMNs were collected, after induction of an acute inflammatory reaction, by injection in the rat pleural cavity, of a suspension of calcium pyrophosphate (CaPP) crystals (pleurisy with CaPP) or serum (pleurisy with serum). " 01/01/1987 - "We studied the sequential cellular events that occur during nonspecific pleurisy induced by a nondiffusible, nonantigenic and endotoxin-free irritant, calcium pyrophosphate (CaPP). " 01/01/1987 - "PMNs were collected from the rat pleural cavity after induction of one acute inflammatory reaction (pleurisy induced by injection of a suspension of calcium pyrophosphate crystals). " 07/01/1985 - "PMNs were recruited after the induction of two acute inflammatory reactions (pleurisies induced by isologous serum or a suspension of calcium pyrophosphate (CaPP) crystals). "

Related Drugs and Biologics

1.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
2.	Uric Acid (Urate)
3.	Tin Fluorides (Floran)
4.	Silicon Dioxide (Sand)
5.	Toothpastes
6.	Sodium Fluoride (Ossin)
7.	Adrenocorticotropic Hormone (ACTH)
8.	3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)
9.	Carrageenan
10.	calcium phosphate

Related Therapies and Procedures

1.	Knee Replacement Arthroplasty (Total Knee Replacement)
2.	Lasers (Laser)
3.	Intra-Articular Injections
4.	Arthroplasty
5.	Parathyroidectomy