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Calcium Dobesilate

Subscribe to New Research on Calcium Dobesilate

A drug used to reduce hemorrhage in diabetic retinopathy.

Also Known As:

2,5-Dihydroxybenzenesulfonate; 2,5-Dihydroxybenzenesulfonic Acid; Altana Pharma Oranienburg Brand of Calcium Dobesilate Monohydrate; Calcium Dobesilate (1:1); Calcium Dobesilate Monoammonium Salt; Calcium Dobesilate Monopotassium Salt; Dexium; Dobica; Doxium; Esteve Brand of Calcium Dobesilate; Knoll Brand of Calcium Dobesilate; Sanofi Synthelabo Brand of Calcium Dobesilate; 2,5 Dihydroxybenzenesulfonate; 2,5 Dihydroxybenzenesulfonic Acid; Calcium, Dobesilate; Dobesilate, Calcium; Dobesilate Calcium; Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1)

Networked: 112 relevant articles (9 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chiavaroli, Carlo: 4 articles (10/2010 - 07/2004)
2.	Bozkurt, A K: 3 articles (08/2006 - 01/2002)
3.	Garay, Ricardo P: 3 articles (03/2005 - 07/2004)
4.	Garay, R P: 2 articles (12/2011 - 10/2001)
5.	Berber, Arturo: 2 articles (06/2008 - 09/2002)
6.	Treviño, Carlos: 2 articles (06/2008 - 09/2002)
7.	Ustundag, N: 2 articles (08/2006 - 03/2006)
8.	Koksal, C: 2 articles (08/2006 - 03/2006)
9.	Cortelekoglu, T: 2 articles (08/2006 - 03/2006)
10.	Sayin, A G: 2 articles (08/2006 - 03/2006)

Related Diseases

1.	Diabetic Retinopathy (Retinopathy, Diabetic) 06/01/1978 - "Two independent, double-masked, controlled studies were made to evaluate the efficacy of calcium dobesilate for the treatment of nonproliferative diabetic retinopathy. " 01/01/1977 - "In this double-blind, randomized trial, which lasted for 2 years, the authors investigated the efficacy of calcium dobesilate on diabetic retinopathy. " 01/01/2015 - "Systematic searches of PUBMED, Springer Link and the Cochrane Clinical Trials Database were conducted using the keywords "diabetic retinopathy" and "calcium dobesilate". " 01/01/2015 - "Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy (DR). " 12/01/2006 - "The study was carried out to confirm the effect of calcium dobesilate (CaD) compared to placebo (PLA) on the blood-retinal barrier (BRB) permeability in early diabetic retinopathy (DR). "
2.	Venous Insufficiency 04/01/1990 - "The aim of this double-blind placebo-controlled study was to evaluate the therapeutic efficacy of Doxium in chronic venous insufficiency (CVI). " 06/01/2011 - "To test the efficacy of calcium dobesilate (CaD) in chronic venous insufficiency (CVI). " 04/01/1990 - "Doxium 500 in chronic venous insufficiency: a double-blind placebo controlled multicentre study." 03/31/1990 - "Fourty patients with lower limb chronic venous insufficiency entered a randomised placebo controlled study with calcium dobesilate for one month. " 10/01/1988 - "Calcium dobesilate was studied in a double-blind trial in 30 normal subjects and in 30 patients with chronic venous insufficiency (CVI). "
3.	Varicose Veins (Varicose Vein) 02/01/2003 - "Calcium dobesilate, a capillotropic agent, has been found to be beneficial in the treatment of varicose veins. " 07/01/2009 - "Oxerutins and calcium dobesilate may be of benefit in reducing oedema and rutosides may help to relieve the symptoms of varicose veins in pregnancy. " 12/01/2011 - "Further studies are required to investigate whether a similar action is found in varicose veins from patients orally treated with calcium dobesilate." 08/01/2008 - "Our study highlights the significance of apoptosis in varicose disorders and suggests that calcium dobesilate, which is used in the treatment of varicose veins, could be of benefit by regulating apoptosis." 12/01/2011 - "Calcium dobesilate protected human varicose veins against oxidative stress in vitro at levels that correspond to therapeutic concentrations. "
4.	Paresthesia (Dysesthesia) 03/01/2004 - "Calcium dobesilate improved paresthesias significantly more than placebo in the severe but not in the mild group and the effect on leg volume was also significantly better in the severe group (-7.2% vs -1.6%). " 04/01/1990 - "The results show that at the end of the trial, all the examined parameters (leg oedema, pain, day and night cramps, discomfort, heavy legs, paresthesia and restless legs) were significantly more improved in the Doxium group than in the placebo group: the leg volume was diminished by 3.8% in the Doxium group compared to 1.2% in the placebo (p less than 0.005). "
5.	Muscle Cramp (Cramp) 03/01/2004 - "Calcium dobesilate significantly improved night cramps and discomfort nearly twice as well as placebo, with the number needed to treat (NNT) being 8 (95% CI 4-50) and 4 (95% CI 3-7), respectively. " 04/01/1990 - "The results show that at the end of the trial, all the examined parameters (leg oedema, pain, day and night cramps, discomfort, heavy legs, paresthesia and restless legs) were significantly more improved in the Doxium group than in the placebo group: the leg volume was diminished by 3.8% in the Doxium group compared to 1.2% in the placebo (p less than 0.005). "

Related Drugs and Biologics

1.	cyclo(Arg-Pro) (CI 4)
2.	Calcium Dobesilate
3.	CLS 2210
4.	Biological Markers (Surrogate Marker)
5.	Retinaldehyde (Retinal)
6.	Calcium
7.	Glutathione (Reduced Glutathione)
8.	Glutathione Disulfide (GSSG)
9.	Ca(2+) Mg(2+)-ATPase
10.	Streptokinase

Related Therapies and Procedures

1.	Light Coagulation
2.	Lasers (Laser)
3.	Intravenous Infusions
4.	Myocardial Revascularization