Calcium Channel Blockers (Blockers, Calcium Channel)

A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. Since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.

Also Known As:

Networked: 2633 relevant articles (228 outcomes, 368 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aronow, Wilbert S: 16 articles (01/2015 - 06/2002)
2.	Wang, Ji-Guang: 10 articles (10/2014 - 07/2002)
3.	Wright, Jackson T: 7 articles (10/2015 - 05/2003)
4.	Volpe, Massimo: 7 articles (03/2015 - 11/2007)
5.	Tocci, Giuliano: 7 articles (03/2015 - 11/2007)
6.	Schiffrin, Ernesto L: 7 articles (11/2014 - 06/2005)
7.	Staessen, Jan A: 7 articles (11/2012 - 07/2002)
8.	Touyz, Rhian M: 6 articles (05/2014 - 06/2005)
9.	Bakris, George L: 6 articles (01/2013 - 05/2003)
10.	Thijs, Lutgarde: 6 articles (11/2012 - 07/2002)

Related Diseases

1.	Hypertension (High Blood Pressure) 11/01/2013 - "Calcium channel blockers (CCBs) are an important class of medication useful in the treatment of hypertension. " 03/01/2015 - "Within the possible antihypertensive drug classes currently available for the clinical management of hypertension, both in monotherapy and in combination therapy, drugs inhibiting the renin-angiotensin system and calcium channel blockers (CCBs) have demonstrated to be effective and safe in lowering BP levels and achieving the recommended BP targets with a good tolerability profile. " 11/10/1983 - "Calcium-channel blockers, although not approved in the United States for the treatment of hypertension, may be beneficial in these patients. " 01/01/2014 - "As calcium channel blockers have been safely used in clinics for the treatment of hypertension for more than 30 years, our results suggest they may be a safe therapeutic option for restoring autophagic flux and treating metabolic pathologies in obese patients. " 04/01/2000 - "Since 1980, calcium channel blockers (CCBs) have been used effectively to lower high blood pressure (HBP). "
2.	Stroke (Strokes) 05/01/2011 - "The calcium channel blockers improved the outcome of rehabilitative therapeutic treatment significantly in the patients afflicted by ischemic stroke." 07/01/2007 - "A recent meta-regression analysis demonstrated that calcium channel blockers are effective in reducing risk of stroke, as their effects are not limited to blood pressure reduction. " 10/20/2001 - "Calcium-channel blockers might be especially effective in stroke prevention. " 10/01/2014 - "This study suggests that early initiation of calcium channel blockers is associated with improved outcome after stroke. " 01/01/2014 - "This study investigates the effects of calcium channel blockers and beta-blockers on blood pressure variability in severe ischemic stroke patients. "
3.	Heart Failure 01/01/1998 - "A considerable effort has been made in the last 15 years to evaluate the safety and efficacy of calcium channel blockers (CCBs) in the treatment of patients with chronic congestive heart failure (CHF). " 03/14/2011 - "Calcium channel blockers and β-blockers were found to be less effective in heart failure prevention." 09/01/2006 - "Although recent clinical studies have suggested that long-acting calcium channel blockers (CCBs) have beneficial effects on heart failure, the precise mechanism is unknown. " 07/01/2000 - "No trial's data support the use of inotropic agents or calcium channel blockers in heart failure. " 10/10/1996 - "Previous studies have shown that calcium-channel blockers increase morbidity and mortality in patients with chronic heart failure. "
4.	Myocardial Infarction 10/01/2005 - "Intracoronary calcium-channel blockers administered in the event of no reflow during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) have been shown to improve myocardial perfusion. " 05/01/2008 - "We conducted a study to assess the effect of persistence with therapy in the use of statins, beta blockers, or calcium-channel blockers on the recurrence of myocardial infarction or death in a Medicaid high-risk, largely female, African-American population. " 12/01/2002 - "Short-acting calcium channel blockers (Ca-blockers) have been shown in some studies to increase the risk of myocardial infarction (MI) and post-MI complications. " 03/01/2000 - "In clinical studies, calcium channel blockers have been found to cause adverse cardiovascular reactions after myocardial infarction; however, such effects appear limited to short-acting agents. " 05/01/1997 - "Despite these reserves about the data sources, it is proposed that the case-control study pointing to the risk of acute myocardial infarction during therapy with short-acting calcium channel blockers (CCBs) can be balanced out by another better more recent study, and by a large cohort study from Israel. "
5.	Ischemia 07/01/1989 - "Although clinically beneficial in some patients, data indicate that the cardioprotective effect of calcium channel blockers during supply-side ischemia is less potent than reperfusion with blood. " 11/01/1990 - "The calcium channel blockers seem to be the drug more effective in the control of ischemia and symptoms. " 11/01/1986 - "Further studies about the efficacy of calcium channel blocking drugs in prevention of ischemia after SAH are needed among patients given antifibrinolytic drugs or having early operation. " 08/01/1988 - "To determine the efficacy of calcium channel blockers in preserving neurologic function after central nervous system ischemia, we studied three such agents in two animal models. " 11/01/2011 - "Lastly, there is now consistent observational data to suggest a central role for calcium channel blockers in the treatment of microvascular ischemia and prevention of overt LV systolic dysfunction, although randomized controlled trials are lacking. "

Related Drugs and Biologics

1.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
2.	Diuretics
3.	1,4-dihydropyridine (dihydropyridine)
4.	Calcium
5.	Antihypertensive Agents (Antihypertensives)
6.	Verapamil (Calan)
7.	Amlodipine (Norvasc)
8.	Vasodilator Agents (Vasodilators)
9.	Nifedipine (Adalat)
10.	Angiotensin Receptor Antagonists

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Drug Therapy (Chemotherapy)
3.	Kidney Transplantation
4.	Angioplasty (Angioplasty, Transluminal)
5.	Renal Dialysis (Hemodialysis)