Calciphylaxis

08/01/2013 - "Sodium thiosulfate (STS), which has been proven to be effective in the treatment of uremic calciphylaxis, shows promise; however, reports of its use in non-uremic cases are limited. "
05/01/2012 - "Intravenous sodium thiosulfate has been used successfully to treat renal and normo-renal calciphylaxis. "
08/01/2013 - "Intralesional sodium thiosulfate may be an effective and well-tolerated treatment for localized calciphylaxis. "
08/01/2013 - "Therefore, we hypothesized that intralesional (IL) sodium thiosulfate may be an effective treatment for the deeper lesions of cutaneous calciphylaxis. "
01/01/2008 - "Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment option."

01/01/2008 - "Cinacalcet as first-line treatment for calciphylaxis."
01/01/2011 - "It also supports other authors' findings that cinacalcet may be an important adjunct in the treatment of calciphylaxis."
01/01/2011 - "It was only after initiating cinacalcet that the patient experienced complete wound healing and resolution of her calciphylaxis. "
01/01/2008 - "We present a case of severe proximal calciphylaxis treated with a small dose of the calcimimetic 'Cinacalcet'."
01/01/2008 - "Proximal calciphylaxis treated with calcimimetic 'Cinacalcet'."

06/01/2013 - "Sodium thiosulphate can be a safe and effective treatment option for resistant and severe cases of calciphylaxis."
11/01/2009 - "We herewith report a case of calciphylaxis that was cured using intravenous sodium thiosulphate treatment."
05/01/2013 - "The aim of the present study was to determine the therapeutic response to a multi-interventional treatment regimen with consistent use of sodium thiosulphate (STS) in an Austrian cohort of calciphylaxis patients. "
11/01/2013 - "We also report the effects of the same treatments combined with sodium thiosulphate (STS) in a patient newly diagnosed with calciphylaxis. "
06/01/2013 - "A resistant case of calciphylaxis in a patient on long-term haemodialysis was treated with sodium thiosulphate (50 ml solution with 50% sodium thiosulphate) three times a week during the end of each dialysis session. "

04/01/2005 - "Amino bisphosphonates, have shown to completely inhibit soft tissue calcifications, calciphylaxis and prevent death in animal models. "
06/28/1977 - "The effects of various diphosphonates on a rat model of cardiac calciphylaxis."
12/01/2007 - "Bisphosphonates may be effective in treating calciphylaxis and arteriosclerosis obliterans by reducing the formation of ectopic calcification around blood vessels."
08/01/2008 - "Bisphosphonates have been shown to be effective in animal models of calciphylaxis, and the mechanism of action is believed to be due to inhibition of macrophages and local proinflammatory cytokines and binding to calcified vascular smooth muscle cells to inhibit further arterial calcification. "
07/01/2011 - "What is the role of using sodium thiosulfate or bisphosphonates in the treatment for calciphylaxis?"

10/01/2015 - "Rapidly progressive nonuremic calciphylaxis in the setting of warfarin."
06/01/2014 - "This is especially important in the presence of other risk factors for calciphylaxis, including warfarin use."
01/01/2013 - "This article presents a case of calciphylaxis provoked by reintroduction of warfarin therapy, introducing the possibility of direct induction. "
01/01/2013 - "Warfarin-induced calciphylaxis: a case report and review of literature."
01/01/2013 - "Warfarin-induced calciphylaxis in a chronic hypercalcemic patient."

06/01/2008 - "Vitamin D analogs remain the primary therapy for secondary hyperparathyroidism, although the use of the less hypercalcemic agents is preferred due to concerns of calciphylaxis and vascular calcification. "
01/01/2008 - "Possible mediators of peritoneal calcification in PD patients are assumed to include acetate buffer, overdosage of vitamin D, repeated peritonitis, hypertonic dialysate, calciphylaxis and secondary hyperparathyroidism (SHPT). "
01/01/2015 - "Following her diagnosis of calciphylaxis, supplementation with vitamin D and calcium containing phosphate binders was stopped. "
10/01/2002 - "In the present experiments we have examined the effect of ibandronate on an entirely different type of calcification, the calciphylaxis induced by administration of a challenger to rats previously treated with sub-lethal doses of vitamin D. "
06/01/1996 - "The calcification-prone state, known as calciphylaxis, was induced in 4-week old rats by oral administration of a vitamin-D analog, dihydrotachysterol. "

10/01/2010 - "We therefore diagnosed calciphylaxis and administered intravenous antibiotics and debrided the necrotic soft tissue. "
07/01/2001 - "Clinically this syndrome is known as calciphylaxis; these lesions are usually resistant to aggressive debridement, systemic antibiotics, and revascularization procedures. "
08/01/2013 - "At present, there is no specific therapy for calciphylaxis and general supportive measures, especially antibiotics for the accompanying infection and wound care, are important. "
05/01/2013 - "Non-survivors were older (P = 0.04), showed higher CRP values (P = 0.04), presented more frequently with proximal-type calciphylaxis (P = 0.03), had a higher disease severity score at diagnosis (P = 0.01), were treated more often with antibiotics (P = 0.01) and cinacalcet (P = 0.03) and had a lower remission rate during treatment (P = 0.004) than did survivors. "
04/01/1966 - "[Tetracycline antibiotics and calciphylaxis]."

01/01/2010 - "Paricalcitol, a less calcemic vitamin D analogue, is also a selective vitamin D receptor activator with a number of nonclassic actions (such as inhibition of inflammation and ossification-calcification) that could prove beneficial in cases of calciphylaxis."
08/01/2008 - "As the treatment of calciphylaxis is mainly empirical and controversial, we decided to administer cinacalcet with paricalcitol for the control of hyperparathyroidism and sodium thiosulfate to improve the calcification of the arterioles. "
08/01/2008 - "Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism."
01/01/2003 - "Although not yet extensively used in pediatric patients with secondary hyperparathyroidism, several therapeutic alternatives, such as the less calcemic vitamin D analogs, including paricalcitol [19-nor-1,25-(OH)(2)D(2)] and doxercalciferol [1-alpha-(OH)(2)D(2)], calcimimetics, and the availability of a calcium-free, aluminum-free phosphate binder such as sevelamer hydrochloride and lanthanum carbonate, may play significant roles in the future management of children with secondary hyperparathyroidism to promote linear growth, prevent parathyroid gland hyperplasia, avoid calciphylaxis and, in the long run, avert vascular calcifications."

12/15/2007 - "Potential treatment of calciphylaxis with vitamin K(2): Comment on the article by Jacobs-Kosmin and DeHoratius."
05/01/2013 - "We report a case of warfarin-induced calciphylaxis treated successfully with sodium thiosulphate and discuss the role of Vitamin K2 as a potential therapeutic option in the management of warfarin-induced calciphylaxis."

08/01/2008 - "Bisphosphonates have been shown to be effective in animal models of calciphylaxis, and the mechanism of action is believed to be due to inhibition of macrophages and local proinflammatory cytokines and binding to calcified vascular smooth muscle cells to inhibit further arterial calcification. "
03/01/2010 - "Some of the most important non traditional risk factors in uremic patients are: the inflammatory state of the patients, cytokines and growth factors, hyperhomocysteinemia, the presence of alterations of the calcium phosphorous product which can already be in progress when the glomerular filtration rate decreases to less than 60 mL/min. Clinically, these alterations cause vascular calcifications, calcifications of the heart valves and calcific uremic arteriolopathy or calciphylaxis. "

04/01/2000 - "This study evaluates the success of parathyroidectomy in reversing the ill effects of calciphylaxis in both our patient population and the literature. "
10/01/2013 - "Calciphylaxis and subtotal parathyroidectomy: a double-edged sword."
07/01/2012 - "Patients with calciphylaxis have an extremely high mortality rate, diagnosis requires a high degree of clinical suspicion and the role and extent of parathyroidectomy in the management of this condition remain controversial. "
01/01/2008 - "The management of calciphylaxis is challenging owing to the lack of optimal medical therapy, although parathyroidectomy has shown some benefit. "
09/01/2007 - "To our knowledge, this is the first reported case of calciphylaxis recurrence after subtotal parathyroidectomy. "

06/01/2010 - "No standard treatment has been established for atypical calciphylaxis; however, a potentially beneficial treatment is hyperbaric oxygen therapy (HBOT). "
07/01/2015 - "The aim of this study was to determine whether hyperbaric oxygen therapy (HBOT) is effective in healing calciphylaxis lesions and to determine if there are any patient factors that can predict wound healing and patient survival. "
09/01/2008 - "Management of calcific uremic arteriolopathy (calciphylaxis) with a combination of treatments, including hyperbaric oxygen therapy."
12/01/2002 - "Hyperbaric oxygen therapy in the treatment of calciphylaxis? "
06/01/1994 - "The results in our case indicate that hyperbaric oxygen therapy may be useful in the treatment of skin ulcers secondary to calciphylaxis."

08/01/2014 - "Calciphylaxis incidence continued to rise even after limiting the study period to 2007 onwards (from 3.7 to 5.7 per 10,000 chronic hemodialysis patients; r = 0.91, p = 0.02). "
08/01/2002 - "The outpatient hemodialysis population has a reported calciphylaxis prevalence of 1% to 4.1%; however, published studies contain only a few case reports of penile calciphylaxis. "
08/01/2014 - "Mortality rates among calciphylaxis patients were noted to be 2.5-3 times higher than average mortality rates for chronic hemodialysis patients. "
01/01/2014 - "We describe the case of a 71-year-old Asian woman on hemodialysis who presented with suspected calciphylaxis lesions in her lower left leg. "
10/01/2013 - "Acute calciphylaxis precipitated by the initiation of hemodialysis."

06/01/2001 - "Calciphylaxis: a poor prognostic indicator for limb salvage."
12/01/2004 - "Limb salvage in calciphylaxis, symptomatic relief, and improved bone density are substantial benefits to recommend this procedure to patients with renal hyperparathyroidism."
03/01/2003 - "Early recognition of calciphylaxis and multidisciplinary treatment, including diligent wound care, frequent debridement, parathyroidectomy, and appropriate skin grafting or revascularization, can result in improved wound healing and limb salvage."

06/30/2013 - "We report two patients of calciphylaxis treated with surgical debridement and excellent outcome in both cases. "
03/01/2009 - "Should we perform surgical debridement in calciphylaxis?"
09/29/2003 - "Sterile-maggot debridement may constitute a therapy for the ulcerated calciphylaxis at an earlier stage, i.e. "
11/01/2015 - "Cure of the patient's calciphylaxis was achieved through a surgical approach using staged debridement, placement of a dermal regenerative template (Integra Dermal Regeneration Template, Integra Lifesciences, Plainsboro, NJ), and followed by successful skin grafting. "
03/01/2011 - "A multidisciplinary approach involving early diagnosis, aggressive medical management, operative debridement, and parathyroidectomy has the best chance of improving survival in calciphylaxis."