Ceruletide

A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

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Networked: 2076 relevant articles (180 outcomes, 308 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Hyeyoung: 26 articles (01/2021 - 10/2002)
2.	Bhatia, Madhav: 23 articles (05/2016 - 10/2002)
3.	Zhou, Zong-Guang: 22 articles (09/2018 - 10/2002)
4.	Konturek, S J: 22 articles (09/2008 - 01/2000)
5.	Pandol, Stephen J: 21 articles (11/2022 - 04/2002)
6.	Bae, Gi-Sang: 21 articles (11/2020 - 10/2008)
7.	Park, Sung-Joo: 21 articles (11/2020 - 10/2008)
8.	Song, Ho-Joon: 21 articles (11/2020 - 10/2008)
9.	Cuzzocrea, Salvatore: 19 articles (10/2020 - 05/2002)
10.	Tomaszewska, R: 19 articles (10/2010 - 01/2000)

Related Diseases

1.	Pancreatitis 08/01/1998 - "The aim of this study was to test the hypothesis that apoptosis can protect against experimental pancreatitis and induction of apoptosis by an extract of Artemisia asiatica (DA-9601) is beneficial in cerulein-induced pancreatis in rats. " 10/01/2002 - "Inhibition of pancreatic ERK1/2 in vivo affords significant protection against inflammatory sequelae following cerulein-induced acute pancreatitis." 01/01/1991 - "Treatment with this agent significantly ameliorates cerulein-induced acute pancreatitis in rats. " 01/01/2016 - "The ten effective components from DCQD may elicit similar protective effects as DCQD on cerulein-induced pancreatitis. " 12/01/2018 - "In the present study, we investigated the protective effects induced by the recombinant human HGF in a mouse model of cerulein-induced acute pancreatitis. "
2.	Inflammation (Inflammations) 11/01/2023 - "Rectal Tac was effective in reducing pancreatic injury and inflammation in both PEP and cerulein models. " 01/01/2021 - "Here, we aimed to investigate the pancreatic protective effects of NB in ameliorating cerulein-induced pancreatic inflammation and apoptosis in AP model and evaluate the potential mechanism of action. " 02/07/2014 - "fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration." 05/01/2016 - "In this study, we employed caerulein to induce AP-like inflammation in the AR42J rat pancreatic acinar cells to mimic the AP-like acinar cell injury. " 01/10/2024 - "In the caerulein-induced AP model, CQCQD ameliorated pancreatic pathological injury, attenuated systemic inflammation and serum enzymatic levers. "
3.	Chronic Pancreatitis 03/01/2019 - "Cerulein-induced chronic pancreatitis in Swiss albino mice: An improved short-term model for pharmacological screening." 01/01/2021 - "Although clinical trials and animal models have evaluated the alterations of the microbiome in chronic pancreatitis (CP), the gut microbiota composition and diversity in cerulein-induced CP is unknown. " 01/01/2020 - "In this study, we have investigated the effects of BR against cerulein-induced chronic pancreatitis (CP) via inhibition of TGF-β/Smad signaling and M2 macrophages polarization in AMPK dependent manner. " 05/01/1999 - "The purpose of this study was to investigate the morphological changes in the islets observed in a new chronic pancreatitis model with diabetes induced by repetition of cerulein injection plus water-immersion stress in rats. " 05/01/1999 - "Morphological study of pancreatic endocrine in an experimental chronic pancreatitis with diabetes induced by stress and cerulein."
4.	Edema (Dropsy) 12/01/2023 - "Pancreas-specific STX17 knockdown using adenovirus-shSTX17 further exacerbated pancreatic edema, inflammatory cell infiltration and necrotic cell death after cerulein injection. " 03/01/2022 - "Moreover, hBM-MSCadministration results in notably attenuated cerulein-induced histopathological alternationsand edema. " 11/01/2020 - "Administration of Q10 attenuated the severity of AP and its associated pulmonary complication as shown by reduction of acinar cell death, parenchymal edema, inflammatory cell infiltration and alveolar thickening in both cerulein-induced AP and PDL-induced AP. " 05/01/2019 - "In vivo, CLE reduced cerulein-induced pancreatic edema. " 03/01/1995 - "There was less macroscopic pancreatic edema (P < 0.01) in the cerulein + TGH group than in the cerulein + saline group. "
5.	Lung Injury 03/01/2011 - "The aim of this study was to characterize lung injury in caerulein-induced AP. " 03/15/2006 - "Rats with AP-associated lung injury were induced by multiple doses of caerulein, which was demonstrated in the previous studies. " 01/01/2021 - "We established caerulein-induced mouse models of SAP-associated lung injury, which showed that GSDMD-mediated pyroptosis was activated in both pancreatic and lung tissues. " 10/14/2020 - "To investigate the effect of cashew (Anacardium occidentale L.) nuts on pancreatic and lung injury induced by cerulein injection, cerulein (50 μg/kg) was administered to CD1 mice for 10 h. " 09/01/2018 - "Furthermore, MSM reduced caerulein-induced H2 S levels by alleviating the expression of CSE in pancreas and lungs and increased CD34 expression and inhibited nuclear factor (NF)-κB translocation in caerulein-induced AP and associated lung injury. "

Related Drugs and Biologics

1.	Amylases
2.	Secretin
3.	Protease Inhibitors (Protease Inhibitor)
4.	Lipase (Acid Lipase)
5.	Taurocholic Acid (Sodium Taurocholate)
6.	Antioxidants
7.	Superoxide Dismutase
8.	Glucose (Dextrose)
9.	Pancreatic Elastase (Elastase)
10.	Gabexate (Foy)

Related Therapies and Procedures

1.	Oral Administration
2.	Injections
3.	Ligation
4.	Pancreatectomy
5.	Induced Hyperthermia (Thermotherapy)