Caerulein (Ceruletide)

A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

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Networked: 1512 relevant articles (124 outcomes, 229 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bhatia, Madhav: 22 articles (11/2015 - 10/2002)
2.	Konturek, S J: 22 articles (09/2008 - 01/2000)
3.	Zhou, Zong-Guang: 19 articles (01/2014 - 10/2002)
4.	Tomaszewska, R: 19 articles (10/2010 - 01/2000)
5.	Kim, Hyeyoung: 18 articles (12/2014 - 10/2002)
6.	Cuzzocrea, Salvatore: 18 articles (07/2012 - 05/2002)
7.	Mazzon, Emanuela: 16 articles (07/2012 - 05/2002)
8.	Bae, Gi-Sang: 15 articles (10/2015 - 10/2008)
9.	Song, Ho-Joon: 15 articles (10/2015 - 10/2008)
10.	Park, Sung-Joo: 15 articles (10/2015 - 10/2008)

Related Diseases

1.	Pancreatitis 08/01/1991 - "Acute edematous pancreatitis was induced in rats by iv infusion of caerulein (CR) in a supramaximal dose of 7.5 x 10(-6)g x kg-1 x hr-1 during 6 hr. The most important finding of our study was the marked decrease of protein and nonprotein thiol content in pancreatic tissue of rats with CR-induced acute pancreatitis (AP). " 08/01/1998 - "The aim of this study was to test the hypothesis that apoptosis can protect against experimental pancreatitis and induction of apoptosis by an extract of Artemisia asiatica (DA-9601) is beneficial in cerulein-induced pancreatis in rats. " 10/01/2002 - "Inhibition of pancreatic ERK1/2 in vivo affords significant protection against inflammatory sequelae following cerulein-induced acute pancreatitis." 01/01/1991 - "Treatment with this agent significantly ameliorates cerulein-induced acute pancreatitis in rats. " 01/01/2003 - "Pretreatment with A2 receptors agonist seems to be protective against the damage to the pancreas during the course of caerulein-induced acute pancreatitis in rats. "
2.	Edema 03/01/1995 - "There was less macroscopic pancreatic edema (P < 0.01) in the cerulein + TGH group than in the cerulein + saline group. " 05/01/1990 - "Pancreatic edema formation was also reduced significantly at 3.5 and 9 h after the first caerulein i.p. " 02/01/1989 - "After 3.5 h cerulein, an interstitial edema and a beginning accumulation of granulocytes in the pancreatic gland is observed. " 03/01/1986 - "Light microscopy of the pancreas in ceruletide-induced AP rats revealed marked acinar cell vacuolization and intense interstitial edema. " 05/01/1992 - "Intravenous infusion of 10 micrograms/kg.h cerulein inhibited external secretion of the pancreas from one hour and caused macroscopic edema at 3 hours. "
3.	Exocrine Pancreatic Insufficiency 07/01/1995 - "The decrease of plasma amino acid levels in response to cerulein does not reflect pancreatic function and does not permit the diagnosis of pancreatic insufficiency." 07/01/1995 - "Cerulein-induced changes in plasma amino acid concentrations are not a valid test for pancreatic insufficiency." 01/01/1987 - "Cerulein induces hyperplasia of the pancreas in a rat model of chronic pancreatic insufficiency." 10/01/2001 - "Exocrine pancreatic insufficiency was graded, according to the results of the secretin-caerulein test, into mild, moderate and severe. " 10/01/1998 - "In coeliac disease it has been demonstrated that the indirect pancreatic function tests detect a greater percentage of subjects with exocrine pancreatic insufficiency than the secretin-caerulein test. "
4.	Lung Injury 03/01/2011 - "The aim of this study was to characterize lung injury in caerulein-induced AP. " 03/15/2006 - "Rats with AP-associated lung injury were induced by multiple doses of caerulein, which was demonstrated in the previous studies. " 05/01/2012 - "We therefore aimed to characterize lung injury in a clinically-relevant 'two-hit' rat model of caerulein-induced AP combined with intratracheal endotoxin. " 11/15/2011 - "Acute inhibition of NEP contributes to increased SP levels in caerulein-induced AP, which leads to augmented inflammatory responses in the pancreas and associated lung injury." 03/01/2011 - "Caerulein-induced AP results in minor lung injury, which is not sufficient to allow protein permeability and substantially alter respiratory mechanics."
5.	Inflammation 03/01/2014 - "fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration." 09/01/2015 - "Orthotopic inflammation-related pancreatic carcinogenesis in a wild-type mouse induced by combined application of caerulein and dimethylbenzanthracene." 02/01/2015 - "FYDR mice were exposed to cerulein, a potent inducer of pancreatic inflammation. " 06/30/2014 - "In normal mice, cerulein-mediated inflammation induced a decrease in PD2/Paf1 expression, which was later restored upon recovery of the pancreatic parenchyma. " 01/01/2014 - "This attenuated the severity of pancreatic inflammation, especially after cerulein plus LPS treatment. "

Related Drugs and Biologics

1.	Amylases
2.	Secretin
3.	Protease Inhibitors (Protease Inhibitor)
4.	Lipase (Acid Lipase)
5.	Taurocholic Acid (Sodium Taurocholate)
6.	Gabexate (Foy)
7.	Pancreatic Elastase (Elastase)
8.	Melatonin
9.	Superoxide Dismutase
10.	Trypsin

Related Therapies and Procedures

1.	Ligation
2.	Injections
3.	Induced Hyperthermia (Thermotherapy)
4.	Oral Administration
5.	Cholecystectomy