Byssinosis

A condition of BRONCHOCONSTRICTION resulting from hypersensitive reaction to inhaled dust during the initial processing of cotton, flax, or hemp in the textile industry. Symptoms include wheezing and tightness in the chest.

Also Known As:

Networked: 74 relevant articles (0 outcomes, 13 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Silicosis
2.	Poisoning
3.	Immediate Hypersensitivity
4.	Fever (Fevers)
5.	Bronchitis

Experts

1.	Bertazzi, P A: 2 articles (11/2012 - 01/2003)
2.	Christiani, D C: 2 articles (12/2003 - 03/2001)
3.	Olenchock, S A: 2 articles (12/2003 - 03/2001)
4.	Eisen, E A: 2 articles (12/2003 - 03/2001)
5.	Wegman, D H: 2 articles (12/2003 - 03/2001)
6.	Riva, M A: 1 article (11/2012)
7.	Iavicoli, S: 1 article (11/2012)
8.	Cesana, G: 1 article (11/2012)
9.	D'Orso, M I: 1 article (11/2012)
10.	Carnevale, F: 1 article (11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Byssinosis:

1.	AntigensIBA 06/01/1978 - "The authors suggest that further study of the inhaled antigens to which cotton workers are exposed is indicated before discarding immunologic mechanisms to explain the development of byssinosis and other pulmonary disorders to which such workers are subject." 05/01/1979 - "HLA antigen frequencies in flax byssinosis patients." 02/01/1973 - "Pseudoimmune precipitation by the isolated byssinosis "antigen"." 09/19/1964 - "BYSSINOSIS: ANTIBODY TO COTTON ANTIGENS IN NORMAL SUBJECTS AND IN COTTON CARD-ROOM WORKERS." 01/01/1983 - "Preliminary crossed radio-immunoelectrophoretic studies demonstrated that some of these antigens are allergenic in man, suggesting that an IgE-mediated hypersensitivity against cotton dust, or a fungal component of the dust, may be important in byssinosis pathogenesis."
2.	Histamine (Histamine Dihydrochloride)FDA Link 09/01/2001 - "Histamine can cause a severe constriction of the central as well as peripheral airways in cotton dust-exposed workers, enabling a paradoxical effect for a differential diagnosis of byssinosis." 09/01/2001 - "Differential diagnosis of byssinosis by blood histamine and pulmonary function test: a review and an appraisal." 01/01/1989 - "Flax dust-affected histamine reactions were not so distinct: lymphocyte and neutrophil reactivity in byssinosis patients did not exceed the standards. " 01/01/1989 - "[Histamine-related reactions in patients with byssinosis]." 05/01/1984 - "Role of histamine in the aetiology of byssinosis. "
3.	Arachidonic Acid (Vitamin F)IBA 08/01/1990 - "Recent studies have indicated that the condensed tannins present in cotton mill dust stimulate the secretion of neutrophil chemotactic factor and arachidonic acid from resident rabbit alveolar macrophages and that these responses may contribute to the acute pulmonary inflammatory reaction associated with byssinosis. " 06/01/1986 - "Studies of etiopathogenic mechanisms of bronchoconstriction in byssinosis indicate the possible involvement of histamine, 5-HT, platelet-activating factor, and metabolites of arachidonic acid as mediators of bronchoconstriction. "
4.	Benzene (Benzole)IBA 01/01/2003 - "We mention here, in particular, the results of the study of "early" markers of lead intoxication; the research on the carcinogenicity of benzene and aromatic amines; the study of the pathogenesis of silicosis and byssinosis; the study of cytogenetic damage after exposure to industrial toxic chemicals; the technical research for dust abatement in mines. " 11/01/2012 - "Afterwards he conducted pioneering studies on occupational oncology (benzene-induced leukaemia, bladder cancer due to aromatic amines, asbestos-related tumours), pathogenesis of silicosis, encephalopathy in carbon disulfide poisoning, byssinosis and metal fume fever, so influencing international research and the implementation of preventive measures against these conditions. "
5.	AminesIBA 01/01/2003 - "We mention here, in particular, the results of the study of "early" markers of lead intoxication; the research on the carcinogenicity of benzene and aromatic amines; the study of the pathogenesis of silicosis and byssinosis; the study of cytogenetic damage after exposure to industrial toxic chemicals; the technical research for dust abatement in mines. " 11/01/2012 - "Afterwards he conducted pioneering studies on occupational oncology (benzene-induced leukaemia, bladder cancer due to aromatic amines, asbestos-related tumours), pathogenesis of silicosis, encephalopathy in carbon disulfide poisoning, byssinosis and metal fume fever, so influencing international research and the implementation of preventive measures against these conditions. "
6.	EndotoxinsIBA 01/01/1978 - "A study on the role of some endotoxins in the aetiology of byssinosis in cotton and flax industries." 01/01/2003 - "Also, bacteria and fungi present in cotton do not in themselves cause byssinosis, but the endotoxins-heat-stable lipopolysaccharide-protein complexes contained in the cell wall of Gram-negative bacteria-are responsible for the development of this respiratory disease of workers on cotton, flax, and some other fibers. " 04/01/1986 - "Due to recent interest in the possible involvement of bacterial endotoxins in the etiology of byssinosis, we examined the effects of E. " 02/01/2012 - "A century later, the inhalation of spores from thermophilic microorganisms was shown to induce attacks of farmers' lung in patients with this disease, while endotoxins originating from Gram-negative bacteria were identified as causal agents for byssinosis in cotton workers. " 05/01/1994 - "Airborne endotoxins play a role in a variety of occupational diseases such as byssinosis and humidifier's disease and are associated with pulmonary and systemic symptoms. "
7.	Immunoglobulins (Immunoglobulin)IBA 07/01/1979 - "Discrimination between byssinosis and chronic bronchitis in cotton mill workers by serum immunoglobulin patterns." 04/01/1978 - "Immunoglobulins in byssinosis, chronic bronchitis and pulmonary eosinophilia." 01/01/1974 - "Immunology of byssinosis: a study of the reactions between the isolated byssinosis "antigen" and human immunoglobulins." 11/01/1985 - "Byssinosis: serum immunoglobulin and complement concentrations in cotton mill workers."
8.	Serotonin (5 Hydroxytryptamine)IBA 01/01/1984 - "We conclude that the secretion of platelet 5-HT and the aggregation of platelets by tannin could potentially contribute to the pulmonary symptoms associated with byssinosis." 01/01/1985 - "Byssinosis: Release of prostaglandins, thromboxane, and 5-hydroxytryptamine in bronchopulmonary lavage fluid after inhalation of cotton dust extracts." 06/01/1986 - "Studies of etiopathogenic mechanisms of bronchoconstriction in byssinosis indicate the possible involvement of histamine, 5-HT, platelet-activating factor, and metabolites of arachidonic acid as mediators of bronchoconstriction. "
9.	Proanthocyanidins (Procyanidins)IBA 05/01/1996 - "Condensed tannins, present in cotton mill dust, alter the host-defense function of alveolar macrophages and may contribute to the pathogenesis of byssinosis. " 08/01/1990 - "Recent studies have indicated that the condensed tannins present in cotton mill dust stimulate the secretion of neutrophil chemotactic factor and arachidonic acid from resident rabbit alveolar macrophages and that these responses may contribute to the acute pulmonary inflammatory reaction associated with byssinosis. "
10.	Interleukin-8 (Interleukin 8)IBA 08/01/1990 - "Recent studies have indicated that the condensed tannins present in cotton mill dust stimulate the secretion of neutrophil chemotactic factor and arachidonic acid from resident rabbit alveolar macrophages and that these responses may contribute to the acute pulmonary inflammatory reaction associated with byssinosis. "

Therapies and Procedures

1.	Bandages (Bandage) 01/01/1965 - "[Studies on the incidence and etiology of byssinosis in the "Niva" (cotton and bandage factory of Novi Sad)]."
2.	Nephrectomy 07/01/2012 - "We report a known case of Byssinosis who underwent nephrectomy under segmental spinal anesthesia at the low thoracic level. " 07/01/2012 - "Segmental thoracic spinal anesthesia in patient with Byssinosis undergoing nephrectomy."
3.	Spinal Anesthesia 07/01/2012 - "We report a known case of Byssinosis who underwent nephrectomy under segmental spinal anesthesia at the low thoracic level. " 07/01/2012 - "Segmental thoracic spinal anesthesia in patient with Byssinosis undergoing nephrectomy."