Butyrylcholinesterase

05/20/1999 - "As our structure-activity studies predicted, these compounds are highly potent and selective inhibitors of human butyrylcholinesterase (BChE) and will test the novel hypothesis that BChE inhibitors are useful in the treatment of Alzheimer's disease. "
09/01/2022 - "Kinetics and computational study of butyrylcholinesterase inhibition by methylrosmarinate: relevance to Alzheimer's disease treatment."
06/01/2020 - "A molecular modeling study of components of the ginger (Zingiber officinale) extract inside human butyrylcholinesterase: implications for Alzheimer disease."
05/16/2015 - "Although many studies have estimated the association between the butyrylcholinesterase (BCHE) K variant and Alzheimer's disease (AD) risk, the results are still controversial. "
11/23/2004 - "Recent studies indicate that there is a synergic association between butyrylcholinesterase-K variant (BChE-K) and apolipoproteinE-epsilon 4 (ApoE-epsilon 4) to promote risk for Alzheimer's disease (AD). "

01/01/2020 - "Pseudocholinesterase Levels as a Prognostic Marker in Organophosphorous Compound Poisoning."
10/01/2016 - "This prospective, observational study examines the relationship between pseudocholinesterase (PChE) activity and morbidity and mortality in OP poisoning. "
06/01/2015 - "Diagnosis of OP poisoning was based on clinical history of exposure to OP compound and low serum pseudocholinesterase levels. "
12/01/2012 - "Mean pseudocholinesterase levels in our patients with mad honey poisoning were 7139.30 ± 2316.41 U/L (min-max: 1785-12,835). "
12/01/2012 - "Pseudocholinesterase levels are not decreased in grayanotoxin (mad honey) poisoning in most patients."

01/01/2021 - "Molecular imaging agents targeting butyrylcholinesterase (BChE) have shown promise in other neurodegenerative disorders and may have utility in detecting changes to normal appearing white matter in multiple sclerosis (MS). "
09/05/2022 - "Butyrylcholinesterase (BChE) has been more and more attractive for treating neurodegenerative diseases, especially Alzheimer's disease (AD). "
01/01/2022 - "Alzheimer's disease (AD) is a neurodegenerative disease with unknown etiology and pathogenesis, in which butyrylcholinesterase (BuChE) plays an important role in the pathogenesis and progression. "
03/01/2020 - "Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized, among others by abnormal levels of acetyl- and butyrylcholinesterase in the brain. "
08/01/2004 - "Accumulating evidence also indicates that butyrylcholinesterase is likely to be involved in neurodegenerative disorders such as Alzheimer's disease. "

08/01/2015 - "Butyrylcholinesterase (BChE) gene therapy is emerging as a promising concept for treatment of cocaine addiction. "
01/01/2013 - "Butyrylcholinesterase genetic variants: association with cocaine dependence and related phenotypes."
07/11/2005 - "Increasing butyrylcholinesterase activity may be a treatment for cocaine addiction. "
07/16/2014 - "In continuing efforts to develop gene transfer of human butyrylcholinesterase (BChE) as therapy for cocaine addiction, we conducted wide-ranging studies of physiological and metabolic safety. "
01/01/2018 - "Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase."

01/01/2017 - "This study aim to determine changes of serum butyrylcholinesterase (BChE) activity in PD patients and related dementia. "
09/19/2008 - "There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. "
07/24/2008 - "Thus, in addition to various domains of the butyrylcholinesterase active site gorge, such as the peripheral anionic site and the pi-cationic site of the Omega-loop, the E-helix represents a domain that could be exploited for development of specific inhibitors to treat dementias."
07/01/2007 - "Executive dyscontrol in dementia, with emphasis on subcortical pathology and the role of butyrylcholinesterase."
01/03/2005 - "Several lines of evidence indicate that inhibition of butyrylcholinesterase (BuChE) is important in the treatment of certain dementias. "