Butyrates (Butyrate)

03/01/1993 - "These findings indicate that fibre which is associated with high butyrate concentrations in the distal large bowel is protective against large bowel cancer, while soluble fibres that do not raise distal butyrate concentrations, are not protective. "
01/01/2001 - "Butyrate, one of the major products of gut fermentation, is known to inhibit proliferation, induce apoptosis and differentiation, and increase phase II enzyme activities in tumor cells, whereas little information is available on protective effects in less-transformed colon cells. "
04/01/2010 - "Particularly, the reduction of the intracellular availability of butyrate in colonocytes may decrease its protective effects toward cancer in IBD patients."
04/01/2010 - "Efficacy of butyrate analogues in HT-29 cancer cells."
03/01/1993 - "Butyrate production from dietary fibre and protection against large bowel cancer in a rat model."

10/01/1999 - "Despite evidences that butyrate may be beneficial and safety in treating refractory distal ulcerative colitis, results of controlled trials, specially in children will be necessary to prove the efficacy of this therapy."
11/01/2007 - "Butyrate, a bacterial fermentation product, is beneficial for prevention/treatment of ulcerative colitis. "
03/01/2003 - "Topical butyrate has been shown to be effective in the treatment of ulcerative colitis (UC). "
06/01/1996 - "This study shows no substantial deficiency of enzyme activity in the beta-oxidation pathway of butyrate in the mucosa of patients with ulcerative colitis in histological remission."
03/01/2003 - "Topical butyrate improves efficacy of 5-ASA in refractory distal ulcerative colitis: results of a multicentre trial."

01/01/2001 - "Hypothesising that protection against colon cancer may be restricted to butyrate producing fibres, we investigated the factors needed for long term stable butyrate production and its relation to susceptibility to colon cancer. "
01/01/2011 - "In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds."
01/01/2010 - "This study supports the hypothesis that butyrate has more potent antineoplastic effects on colon cancer cells with MLH1 dysfunction. "
07/01/2009 - "Additional animal and human studies are needed to define the exact role of dietary fibre and butyrate in inducing GST activity and reducing the risk of colon cancer."
12/10/2008 - "In parallel, in vitro studies using HT29cl.16E and Caco2 colon cancer cell lines clarified that KLF4 increased coincident with differentiation along both the goblet and absorptive cell lineages, respectively, and that KLF4 levels also increased during differentiation induced by the short chain fatty acid butyrate, independently of cell fate. "

07/01/2003 - "Butyrate showed a significant protection against the decrease in cell viability, increase in mucosal permeability, and polymorphonuclear neutrophil infiltration seen in DSS colitis. "
09/01/2015 - "SFD-t induced the growth of butyrate-producing microbes and was effective in reducing proinflammatory cytokine secretion and enterocyte injury in this mouse model of colitis."
06/01/1996 - "Butyrate is effective in experimental colitis by increasing transglutaminase activity. "
04/01/1996 - "The short chain fatty acid (SCFA) butyrate provides energy for colonocytes, stimulates colonic fluid and electrolyte absorption and is recognised as an effective treatment for multiple types of colitis. "
09/01/2000 - "Butyrate treatment also improved TNBS induced colitis. "

11/15/2012 - "Butyrate, a major SCFA, serves as the primary energy source for the colonic mucosa, maintains epithelial integrity, and ameliorates intestinal inflammation. "
03/28/2011 - "At the intestinal level, butyrate plays a regulatory role on the transepithelial fluid transport, ameliorates mucosal inflammation and oxidative status, reinforces the epithelial defense barrier, and modulates visceral sensitivity and intestinal motility. "
10/01/2010 - "Butyrate serves as primary fuel for the colonocytes and also ameliorates mucosal inflammation. "
04/01/2013 - "Functional studies related to the observed alterations in the gut microbiome are warranted because the low abundance of bifidobacteria and butyrate-producing species could adversely affect the intestinal epithelial barrier function and inflammation, whereas the apparent importance of the Bacteroides genus in development of type 1 diabetes is insufficiently understood."
12/01/2010 - "This study aims to assess the effects of butyrate on inflammation and oxidative stress in subjects with chronically mildly elevated parameters of inflammation and oxidative stress. "