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Butylscopolammonium Bromide (Butylscopolamine)

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Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.

Also Known As:

Butylscopolamine; Buscopan; Buscapine; Buscolysin; Hyoscine N-Butylbromide; N-Butylscopolammonium Bromide; Scopolan; Bromide, Butylscopolammonium; Bromide, N-Butylscopolammonium; Hyoscine N Butylbromide; N Butylscopolammonium Bromide; N-Butylbromide, Hyoscine; Hyoscinbutylbromide; Scopolaminebutylbromide; 3-Oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-

Networked: 130 relevant articles (14 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rondonotti, Emanuele: 2 articles (12/2014 - 08/2013)
2.	Spinzi, Giancarlo: 2 articles (12/2014 - 08/2013)
3.	Amato, Arnaldo: 2 articles (12/2014 - 08/2013)
4.	Paggi, Silvia: 2 articles (12/2014 - 08/2013)
5.	Baccarin, Alessandra: 2 articles (12/2014 - 08/2013)
6.	Radaelli, Franco: 2 articles (12/2014 - 08/2013)
7.	Tatsumi, Norifumi: 1 article (07/2015)
8.	Arihiro, Seiji: 1 article (07/2015)
9.	Davern, A J: 1 article (07/2015)
10.	Hashimoto, Hisashi: 1 article (07/2015)

Related Diseases

1.	Pain (Aches) 10/14/1998 - "With use of hyoscine N-butylbromide, 7 out 16 patients had significant pain relief at 30 min (mean pain score decreased from 2.62 +/- 1.01 to 0.57 +/- 0.53, p < 0.05) and 3 other patients relieved at 60 min (mean pain score decreased to 0.66 +/- 0.57, p < 0.05). " 12/01/2013 - "Butylscopolamine, a peripheral antimuscarinic agent, is effective for relieving the pain, which is because of smooth muscle contraction. " 03/01/2012 - "Administration of 10 mg antispasmodic drug hyoscine-N-butylbromide does not reduce pain in patients undergoing HyCoSy." 03/01/2012 - "There was no difference in pain score between the hyoscine-N-butylbromide group and the placebo group (P = 0.807). " 03/01/2012 - "To assess the effectiveness of an antispasmodic drug, hyoscine-N-butylbromide, in reducing pain during hysterosalpingo-contrast sonography (HyCoSy). "
2.	Diverticulum 10/01/2008 - "In the sigmoid colon, Buscopan had a significantly greater impact on obtaining optimal distention in those with diverticulosis than in those without. " 10/01/2003 - "In patients with diverticular disease, IV Buscopan did not have any significant effect on segments affected by diverticulosis but was associated with an improvement in distension of more proximal segments. "
3.	Colic (Abdominal Cramps) 07/01/2015 - "N-butylscopolammonium bromide (NBB) is an anticholinergic agent used to treat spasmodic colic in horses. " 11/01/2012 - "N-butylscopolammonium bromide (NBB) is an anticholinergic drug used to relieve spasmodic colic in horses, but its effect on airway smooth muscle is unknown. " 03/01/1967 - "[Algo-buscopan in the treatment of nephritic colic]." 11/01/1995 - "We compared the efficacy of flurbiprofen (NSAID) versus dipirone + hyoscine N-butylbromide in the treatment of nephric colic. " 11/01/1995 - "The results of the study show that IM flurbiprofen is a useful alternative to dipirone + hyoscine N-butylbromide in the treatment of nephric colic."
4.	Gastroesophageal Reflux (GERD) 08/01/2001 - "The number of reflux episodes was significantly greater with hyoscine N-butylbromide in comparison with a placebo in patients with gastroesophageal reflux disease and normal subjects (p < 0.02). " 08/01/2001 - "Hyoscine N-butylbromide, an anticholinergic agent, increases the total number of esophageal acid refluxes in patients with gastroesophageal reflux disease and in controls, therefore it is not recommended in the treatment of gastroesophageal reflux disease." 08/01/2001 - "The mean 24-h gastric pH after hyoscine N-butylbromide was not different from placebo in gastroesophageal reflux disease and controls. " 08/01/2001 - "Effect of hyoscine N-butylbromide on gastroesophageal reflux in normal subjects and patients with gastroesophageal reflux disease." 12/01/1994 - "There was no significant difference in the overall occurrence (p = 0.41) or degree (p = 0.81) of gastroesophageal reflux before and after injection of Buscopan (chi 2 test). "
5.	Renal Colic 01/01/2014 - "To investigate the evidence for the use of hyoscine N-butylbromide (HBB) in the treatment of acute renal colic. " 01/01/2014 - "Hyoscine N-butylbromide (Buscopan®) in the treatment of acute ureteral colic: what is the evidence?" 03/01/2012 - "Butylscopolamine is not recommended for the treatment of renal colic." 01/22/1958 - "[Buscopan in the treatment of renal colic; 6 cases]." 01/01/2014 - "A literature search was performed using the keywords 'hyoscine N-butylbromide', 'ureteral colic', 'spasmolytic', 'anticholinergic' and 'analgesia'. "

Related Drugs and Biologics

1.	Dipyrone (Metamizole)
2.	Tramadol
3.	Barium
4.	Sodium
5.	Ketoprofen (Orudis)
6.	Flurbiprofen (Froben)
7.	thiaton (tiquizium bromide)
8.	Acetaminophen (Paracetamol)
9.	peppermint oil
10.	Octreotide (Sandostatin)

Related Therapies and Procedures

1.	Tubal Sterilization (Tubal Ligation)
2.	Diathermy
3.	Nebulizers and Vaporizers (Inhaler)
4.	Intravenous Injections
5.	Local Anesthesia