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Buspirone (Buspar)

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to DIAZEPAM.

Also Known As:

Buspar; Bespar; Anxut; Apo-Buspirone; Apotex Brand of Buspirone Hydrochloride; Armstrong Brand of Buspirone Hydrochloride; Bristol-Myers Brand of Buspirone Hydrochloride; Bristol-Myers Squibb Brand of Buspirone Hydrochloride; Busp; Buspirone Hydrochloride; Eisai Brand of Buspirone Hydrochloride; Gen-Buspirone; Genpharm Brand of Buspirone; Hexal Brand of Buspirone Hydrochloride; Hormosan Brand of Buspirone Hydrochloride; Lin-Buspirone; Linson Pharma Brand of Buspirone Hydrochloride; MJ-9022-1; N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide; Neurosine; Novo-Buspirone; Novopharm Brand of Buspirone Hydrochloride; Nu-Buspirone; Nu-Pharm Brand of Buspirone Hydrochloride; PMS-Buspirone; Pharmascience Brand of Buspirone Hydrochloride; Ratiopharm Brand of Buspirone Hydrochloride; UPSA Brand of Buspirone Hydrochloride; ratio-Buspirone; Apo Buspirone; Bristol Myers Brand of Buspirone Hydrochloride; Bristol Myers Squibb Brand of Buspirone Hydrochloride; Gen Buspirone; Hydrochloride, Buspirone; Lin Buspirone; MJ 9022 1; MJ90221; Novo Buspirone; Nu Buspirone; Nu Pharm Brand of Buspirone Hydrochloride; PMS Buspirone; ratio Buspirone; 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-

Networked: 560 relevant articles (86 outcomes, 125 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Le Foll, Bernard: 4 articles (01/2016 - 03/2013)
2.	Brady, Kathleen T: 4 articles (11/2015 - 09/2006)
3.	Fava, Maurizio: 4 articles (09/2015 - 03/2006)
4.	Nierenberg, Andrew A: 4 articles (12/2012 - 03/2006)
5.	McRae-Clark, Aimee L: 3 articles (11/2015 - 11/2009)
6.	Kline, Anthony E: 3 articles (12/2014 - 07/2012)
7.	Cheng, Jeffrey P: 3 articles (12/2014 - 07/2012)
8.	Sessler, Daniel I: 3 articles (07/2009 - 01/2004)
9.	Boileau, Isabelle: 2 articles (01/2016 - 03/2013)
10.	Baker, Nathaniel L: 2 articles (11/2015 - 10/2015)

Related Diseases

1.	Anxiety Disorders (Anxiety Disorder) 01/01/1997 - "Buspirone is a nonbenzodiazepine anxiolytic that has been effective in uncontrolled trials for treating childhood anxiety disorders. " 05/01/1996 - "Buspirone is effective for the treatment of anxiety disorders in children. " 07/01/1996 - "This study was designed to evaluate the anxiolytic efficacy of buspirone in patients with a diagnosis of generalized anxiety disorder (GAD) with coexisting mild depressive symptoms. " 01/01/1999 - "Buspirone is an azapirone with 5-HT1A partial agonist activity which has demonstrated efficacy in the treatment of generalized anxiety disorder, commonly referred to as persistent anxiety. " 07/01/1996 - "Efficacy of buspirone in generalized anxiety disorder with coexisting mild depressive symptoms."
2.	Panic Disorder (Panic Attack) 02/01/1990 - "Is buspirone effective for panic disorder?" 09/01/1990 - "Studies conducted with patients suffering from panic disorder have so far been inconclusive, and thus buspirone is, for the present at least, not recommended for routine treatment of panic disorder. " 02/24/1990 - "Buspirone metabolite and panic attacks." 02/01/1990 - "Buspirone was not significantly superior to placebo in its antipanic or anxiolytic effects in panic disorder patients." 08/01/1988 - "Buspirone in the treatment of panic disorder: a controlled pilot comparison with clorazepate."
3.	Phobic Disorders (Phobia) 04/01/1997 - "The results of open pilot studies suggest that the serotonin-1A (5-HT1A) receptor agonist buspirone might be effective in social phobia. " 04/01/1997 - "In the present study, the efficacy of buspirone was investigated in patients with social phobia using a 12-week double-blind placebo-controlled design. " 04/01/1997 - "The results of the study do not support the results of open studies, in which a reduction of social anxiety and social avoidance was reported in patients with social phobia treated with buspirone." 04/01/1997 - "Clinical effects of buspirone in social phobia: a double-blind placebo-controlled study." 08/01/1993 - "The results suggest that buspirone may have modest efficacy in the treatment of social phobia, but confirmation in a placebo-controlled trial is required."
4.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 12/01/1998 - "The most recent studies have been unable to demonstrate the efficacy of buspirone in smoking cessation or in the relief of withdrawal symptoms. " 05/01/2003 - "It is concluded that buspirone was effective in attenuating the objective and subjective withdrawal symptoms that follow opiate use cessation." 02/01/1992 - "In a double-blind, randomized, placebo-controlled trial, we determined the effects of buspirone on the withdrawal symptoms associated with smoking cessation in 40 long-term cigarette smokers. " 01/01/1992 - "Buspirone effect on tobacco withdrawal symptoms: a randomized placebo-controlled trial." 01/01/1991 - "This paper reports on a double blind trial of the effect of buspirone, 15 mg per day, on cigarette withdrawal symptoms and ability of smokers to maintain abstinence during treatment. "
5.	Major Depressive Disorder (Major Depressive Disorders) 01/01/1986 - "Open trial of buspirone in the treatment of major depressive disorder." 04/01/1994 - "We administered the serotonin-1a agonist buspirone (0.4 mg/kg orally) as a neuroendocrine challenge agent to a group of male patients with DSM-III-R major depressive disorder (MDD) (n = 13) and a group of male healthy controls (n = 10). " 01/01/2015 - "In this review presents the results of clinical trials of buspirone as an adjunctive therapy in cases with previous ineffective use of antidepressants in patients with major depressive disorder." 12/01/2012 - "Based on these data, we conducted an exploratory 6-week, multi-center, double-blind, randomized, placebo- and comparator-controlled study of the combination of buspirone and melatonin in subjects with acute Major Depressive Disorder (MDD). " 12/01/2012 - "An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery."

Related Drugs and Biologics

1.	Benzodiazepines
2.	Serotonin 5-HT1 Receptor Agonists
3.	Antidepressive Agents (Antidepressants)
4.	Serotonin (5 Hydroxytryptamine)
5.	Bupropion (Wellbutrin)
6.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)
7.	Alprazolam (Xanax)
8.	Fluoxetine (Prozac)
9.	Citalopram (Escitalopram)
10.	Imipramine (Janimine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Analgesia
4.	Self Administration (Administration, Self)
5.	Intraperitoneal Injections