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Burimamide
An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.
Also Known As:
Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl-
Networked:
18
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Thiourea: 362
Burimamide: 18
Sulfur Compounds: 278
Thiourea: 362
Burimamide: 18
Related Diseases
1.
Vomiting
06/01/1976 - "
1 The protective effects of the intracerebroventicular (i.c.v.) administration of the H1-receptor antagonist, mepyramine and the H2-receptor antagonists, burimamide and metiamide on centrally induced histamine-emesis were studied in unanaesthetized dogs.
"
06/01/1976 - "
3 Although burimamide (i.c.v. or i.v.) afforded protection against histamine-induced emesis, there was no protection against intravenous apomorphine-or oral copper sulphate-induced emesis.
"
2.
Anaphylaxis (Anaphylactic Shock)
08/01/1973 - "
1. Anaphylaxis was induced in the isolated heart of the guinea-pig in the presence of burimamide at concentrations of 4 x 10(-5)M and 2.7 x 10(-4)M.2.
"
10/01/1973 - "
Burimamide, the selective histamine H(2)-receptor antagonist, potentiated the depressor actions of histamine and anaphylaxis.
"
08/01/1973 - "
Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.
"
04/01/1976 - "
Tripelennamine and methysergide reduced anaphylaxis minimally and burimamide not at all.
"
08/01/1973 - "
Neither the negative dromotropic effect nor the decrease in coronary flow rate occurring during anaphylaxis were inhibited by burimamide.4. The results are in agreement with the double histamine receptor theory and suggest that, in the heart of the guinea-pig, H(2)-receptors are involved in the positive inotropic and chronotropic effects of released histamine, and H(1)-receptors in the negative dromotropic effect.
"
3.
Shock
06/01/1978 - "
Rats pretreated with the H(2)-receptor antagonist, burimamide, demonstrated an exacerbated mortality after induction of shock.
"
09/01/1975 - "
Although separate administration of antagonists of H1 - or H2 - histamine receptors had no effect on mortality, pretreatment with both diphenhydramine and burimamide significantly increased shock mortality.
"
06/01/1978 - "
Various single doses of diphenhydramine, chlorpheniramine, promethazine, and burimamide were administered intravenously to Wistar rats subjected to hemorrhagic or bowel ischemia shock.
"
4.
Hypertension (High Blood Pressure)
03/01/1977 - "
Following burimamide both an initial arterial hypertension and a subsequent hypotension were observed the latter being more pronounced in the group with histamine release.
"
10/01/1992 - "
4. The inhibition of CNS-induced hypertension by (R)-alpha-methylhistamine (300 micrograms kg-1, i.v.) was blocked by the H3 antagonists, thioperamide (ID50 = 0.39 mg kg-1, i.v.), impromidine (ID50 = 0.22 mg kg-1, i.v.) and burimamide (ID50 = 6 mg kg-1, i.v.).
"
5.
Ulcer
01/01/1979 - "
The prostaglandins E2 and 16,16-dimethyl-PGE2 methyl ester were compared with the H2-receptor antagonists burimamide and metiamide for their effects on gastric acid secretion (GAS) and gastric mucosal blood flow (MBF) in rats and dogs, and on ulcer formation in rats.
"
Related Drugs and Biologics
1.
Histamine (Histamine Dihydrochloride)
2.
Pyrilamine (Mepyramine)
3.
Metiamide
4.
Copper
5.
Apomorphine
6.
Histamine Receptors (Histamine Receptor)
7.
Impromidine (SK&F-92676)
8.
Diphenhydramine (Benadryl)
9.
Chlorpheniramine (Chlorphenamine)
10.
thioperamide