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Bumetanide (Bumex)

A sulfamyl diuretic.

Also Known As:

Bumex; AstraZeneca Brand of Bumetanide; Atlantis Brand of Bumetanide; Bumedyl; Bumethanide; Burinex; Drenural; Farmacusi Brand of Bumetanide; Fordiuran; Grossmann Brand of Bumetanide; Leo Brand of Bumetanide; Miccil; PF-1593; Roche Brand of Bumetanide; Senosiain Brand of Bumetanide; Bumetanide AstraZeneca Brand; Bumetanide Atlantis Brand; Bumetanide Farmacusi Brand; Bumetanide Grossmann Brand; Bumetanide Leo Brand; Bumetanide Roche Brand; Bumetanide Senosiain Brand; PF 1593; PF1593; Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-

Networked: 353 relevant articles (36 outcomes, 52 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58

Experts

1.	O'Donnell, Martha E: 11 articles (05/2014 - 09/2004)
2.	Kahle, Kristopher T: 8 articles (07/2015 - 09/2008)
3.	Anderson, Steven E: 7 articles (05/2014 - 09/2004)
4.	Staley, Kevin J: 7 articles (02/2011 - 11/2005)
5.	Sun, Dandan: 6 articles (07/2015 - 01/2003)
6.	Ben-Ari, Yehezkel: 6 articles (02/2015 - 08/2008)
7.	Lam, Tina I: 6 articles (05/2014 - 09/2004)
8.	Löscher, Wolfgang: 5 articles (01/2015 - 06/2010)
9.	Brandt, Claudia: 5 articles (01/2015 - 06/2010)
10.	Jensen, Frances E: 4 articles (04/2015 - 11/2005)

Related Diseases

1.	Seizures (Seizure) 09/01/2009 - "The obtained results provide further evidence that bumetanide may be beneficial for treating neonatal seizures, and that NKCC1 represents a potential target for antiepileptic interventions in the immature brain." 05/01/2015 - "Preclinical data suggest that the loop-diuretic bumetanide might be an effective treatment for neonatal seizures. " 11/01/2005 - "Our results provide evidence that NKCC1 facilitates seizures in the developing brain and indicate that bumetanide should be useful in the treatment of neonatal seizures." 02/25/2015 - "Moreover, the relative expression of the cation-chloride cotransporters (CCC) NKCC1 (Slc12a2) and KCC2 (Slc12a5), which are responsible for establishing the neuronal Cl(-) gradient that governs GABAergic inhibition were altered and the NKCC1 inhibitor bumetanide eliminated seizures in a subgroup of mice. " 05/01/2015 - "Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial."
2.	Edema 11/01/1981 - "Bumetanide mobilizes peripheral edema effectively in most patients and leads to improvement in functional physical capacity. " 02/01/1997 - "The continuous infusion of the loop diuretic, bumetanide, has been shown to be effective in the treatment of severe refractory edema. " 08/01/2010 - "Edema formation was significantly more robust in young mice and was reduced with Bumetanide. " 02/11/2009 - "However, bumetanide (BUM), a diuretic blocker of Na(+)-K(+)-2Cl(-) channels, and L-644, 711, a nondiuretic anion channel inhibitor--both lacking antioxidant capabilities as well as reportedly ineffective against alcohol-dependent brain damage in vivo--reduced neither alcohol-induced neurotoxicity nor (with BUM) edema in HEC slices. " 10/01/2008 - "We investigated CBF and edema formation in a rat model of DKA and determined the effects of bumetanide, an inhibitor of Na-K-Cl cotransport. "
3.	Autistic Disorder (Autism) 09/01/2015 - "Treatment with bumetanide combined with ABA training may result in a better outcome in children with autism than ABA training alone." 02/01/2015 - "The improvement of emotion processing by bumetanide reinforces the usefulness of bumetanide as a promising treatment to improve social interactions in autism. " 01/01/2012 - "Therefore, bumetanide is a promising novel therapeutic agent to treat autism. " 02/01/2015 - "In a previous double-blind randomized study, we have shown that the diuretic NKCC1 chloride importer antagonist bumetanide, that decreases (Cl-)i and reinforces GABAergic inhibition, reduces the severity of autism symptoms. " 09/01/2015 - "The purpose of this study was to investigate the therapeutic effects of combined bumetanide and applied behavior analysis (ABA) treatment in children with autism. "
4.	Ischemia 03/01/2007 - "Bumetanide or genetic ablation of NKCC1 attenuated mitochondrial dysfunction and astrocyte death following ischemia. " 08/01/2004 - "Astrocytes showed marked swelling during ischemia in the absence of extracellular Ca2+, which was blocked by bumetanide. " 08/01/2004 - "Astrocytes showed rapid [Na+]i increases during ischemia and cell death was reduced to control levels by substitution of extracellular Na+ or Cl- or by perfusion with bumetanide, a selective Na-K-Cl cotransport (NKCC) blocker. " 01/24/2003 - "Artificial cerebral spinal fluid (aCSF) or 100 microM bumetanide in aCSF were continuously microdialyzed into left cortices either 1 h prior to ischemia plus 2-h ischemia, or only during 24-h reperfusion. " 02/01/1996 - "For the same protocol, the presence of bumetanide resulted in increased [Ca]i during ischemia and reperfusion (P < 0.05); these increases in [Ca]i are interpreted to be the result of increased Nai. "
5.	Heart Failure 01/01/2013 - "The primary objective of this study was to estimate a dose-response effect of IV bumetanide on urine output (UOP) in all patients that received 48 hours of therapy as well as in a subgroup of patients with heart failure (HF). " 02/01/1997 - "Heart failure patients receiving continuous infusions of bumetanide were monitored for the development of musculoskeletal symptoms. " 02/01/1997 - "To evaluate the characteristics of bumetanide-induced musculoskeletal symptoms during continuous i.v. infusion in patients with severe heart failure. " 11/01/1988 - "Four healthy subjects and six patients with congestive heart failure (CHF) were given 3 mg oral and intravenous doses of bumetanide in a random crossover fashion. " 11/01/1988 - "Kinetics, dynamics, and bioavailability of bumetanide in healthy subjects and patients with congestive heart failure."

Related Drugs and Biologics

1.	Furosemide (Lasix)
2.	Phenobarbital (Luminal)
3.	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)
4.	Sodium
5.	Sodium-Potassium-Chloride Symporters
6.	Carbon Monoxide
7.	Bendroflumethiazide (Naturetin)
8.	quinapril (Accupril)
9.	1-phenyl-3,3-dimethyltriazene (PDT)
10.	Diuretics

Related Therapies and Procedures

1.	Sodium-Restricted Diet (Diet, Sodium Restricted)
2.	Ligation
3.	Aftercare (After-Treatment)
4.	Oral Administration
5.	Heterologous Transplantation (Xenotransplantation)