Bronchopulmonary Sequestration (Pulmonary Sequestration)

A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.

Also Known As:

Networked: 230 relevant articles (4 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Edema (Dropsy)
2.	Shock
3.	Neoplasms (Cancer)
4.	Pleural Effusion (Pleural Effusions)
5.	Congenital Cystic Adenomatoid Malformation of Lung (Cystic Adenomatoid Malformation of Lung)

Experts

1.	Deng, Yujiao: 2 articles (06/2022 - 01/2022)
2.	Fang, Xin: 2 articles (06/2022 - 01/2022)
3.	Wu, Bing: 2 articles (06/2022 - 01/2022)
4.	Li, Rui: 2 articles (10/2018 - 12/2016)
5.	Liu, Lunxu: 2 articles (05/2018 - 09/2013)
6.	Ruano, Rodrigo: 2 articles (12/2012 - 09/2007)
7.	Zugaib, Marcelo: 2 articles (12/2012 - 09/2007)
8.	Klumper, F J C M: 2 articles (09/2009 - 04/2007)
9.	Lopriore, E: 2 articles (09/2009 - 04/2007)
10.	Oepkes, D: 2 articles (09/2009 - 04/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bronchopulmonary Sequestration:

1.	Radioisotopes (Radionuclides)IBA 03/01/1978 - "A radionuclide hemodynamic study was helpful in demonstrating blood supply from the aberrant artery in pulmonary sequestration. " 03/01/1978 - "Radionuclide study in pulmonary sequestration." 09/01/1985 - "Radionuclide angiography clearly revealed the condition of both the pulmonary artery and aorta, and is considered to be extremely useful in the diagnosis of pulmonary sequestration. " 09/01/1985 - "We report a case diagnosed as pulmonary sequestration by radionuclide angiography prior to operation which showed anomalous arteries. " 09/01/1985 - "Radionuclide angiography in pulmonary sequestration."
2.	CytokinesIBA 01/01/2019 - "PAE-induced ALI presents with lung inflammation with neutrophilic sequestration, pulmonary edema, hyperpermeability, increased cytokine levels, and activation of the NF-κB pathway. " 12/01/2006 - "Topical p38 MAPK inhibition resulted in significantly less pulmonary inflammatory response via reduction of pulmonary neutrophil sequestration, pulmonary cytokine expression, and a significant reduction in pulmonary microvascular injury and edema formation. " 10/01/2009 - "Sevoflurane attenuates the pulmonary sequestration of neutrophil and leukocytes and also preserves the pulmonary consumption of cytokines at the time of early pulmonary reperfusion. " 03/01/2003 - "Hypothermia pretreatment decreased the pulmonary sequestration of neutrophils, induced a favorable balance between pro- and anti-inflammatory cytokines, and attenuated histologic injury in endotoxin-challenged rats."
3.	p38 Mitogen-Activated Protein KinasesIBA 12/01/2006 - "Topical p38 MAPK inhibition resulted in significantly less pulmonary inflammatory response via reduction of pulmonary neutrophil sequestration, pulmonary cytokine expression, and a significant reduction in pulmonary microvascular injury and edema formation. "
4.	AntigensIBA 05/01/1989 - "There was no platelet pulmonary sequestration as studied with 111Indium-labeled platelets during 24 hours after the antigen challenge, and the life span of circulating platelets was normal. " 02/01/2020 - "Association of pulmonary sequestration with elevated serum cancer antigen 125 levels: a case report." 10/18/2021 - "This study aimed to determine the underlying pathophysiologic mechanism of elevated carbohydrate antigen 19-9 (CA19-9) in pulmonary sequestration (PS) patients. " 06/01/2018 - "Pulmonary sequestration associated with a synchronous elevation of carbohydrate antigen 50 and 19-9: a case report." 12/01/2016 - "Elevated Carbohydrate Antigen 19-9 Level in a Patient with Horseshoe Type Pulmonary Sequestration."
5.	Tumor Biomarkers (Tumor Markers)IBA 08/01/2018 - "Pulmonary sequestration associated with increased serum tumor markers and elevated standard uptake value level in PET/CT: A case report and literature review." 08/01/2016 - "[Pulmonary Sequestration Associated with Increased Serum Tumor Markers;Report of a Case]." 02/01/2007 - "The association between pulmonary sequestration and increased tumor markers levels is overlooked in western literature, but it is often reported by many Japanese authors. " 12/01/1997 - "A 39-year old female was found to have intralobar pulmonary sequestration with a high serum level of the tumor markers, CA19-9, CA125 and NCC-ST-439. " 12/01/1997 - "[A resected case of intralobar pulmonary sequestration with increased serum tumor markers, CA19-9, CA125 and NCC-ST-439]."
6.	CarbohydratesIBA 10/18/2021 - "This study aimed to determine the underlying pathophysiologic mechanism of elevated carbohydrate antigen 19-9 (CA19-9) in pulmonary sequestration (PS) patients. " 06/01/2018 - "Pulmonary sequestration associated with a synchronous elevation of carbohydrate antigen 50 and 19-9: a case report." 12/01/2016 - "Elevated Carbohydrate Antigen 19-9 Level in a Patient with Horseshoe Type Pulmonary Sequestration." 10/01/2016 - "Pulmonary sequestration associated with significant elevation of serum carbohydrate antigen 19-9: report of two cases." 01/01/2015 - "A Case Report and a Short Literature Review of Pulmonary Sequestration Showing Elevated Serum Levels of Carbohydrate Antigen 19-9."
7.	Muromonab-CD3 (Muromonab CD3)FDA Link 01/01/1994 - "In the present study the consequences of administration of low-dose (0.5 mg) OKT3 for respiratory side-effects and pulmonary sequestration of labelled granulocytes are compared with the known effects of 5 mg OKT3. " 05/01/1993 - "Therefore, we studied complement activation in relation to activation and pulmonary sequestration of neutrophils during antirejection treatment with OKT3. " 05/01/1993 - "Respiratory side effects that sometimes occur during treatment with anti-CD3 MAb OKT3 might result from pulmonary sequestration of activated neutrophils. " 05/01/1993 - "In five studied patients treated with OKT3, pulmonary sequestration of radiolabeled granulocytes was observed from 3 until 15 minutes after the first dose of OKT3, together with peripheral blood granulocytopenia, which lasted at least 30 minutes. " 05/01/1993 - "In conclusion, we demonstrate a simultaneous activation of complement and pulmonary sequestration of activated granulocytes immediately following the first dose of OKT3. "
8.	BariumIBA 02/01/2012 - "Computerized axial tomography scan and barium swallowing study were performed, revealing a suspected intralobar pulmonary sequestration associated with sliding gastric hernia. " 10/01/1976 - "Hiatal hernia should be ruled out by barium swallow; acute pulmonary abscess by the lack of a history suggestive of a necrotizing pneumonia; bronchiectasis by bronchogram; and intralobar bronchopulmonary sequestration should be confirmed by aortography."
9.	MX1520IBA 06/01/2004 - "Studies using transgenic sickle mice, which nearly exclusively develop pulmonary sequestration upon exposure to hypoxia, showed that oral administration of MX-1520 prior to hypoxia exposure significantly reduced the percentage of sickled cells in the blood. "
10.	1- methyl- 4- cyclohexyl- 1,2,3,6- tetrahydropyridineIBA 06/15/1989 - "To study the role of platelets in monocrotaline pyrrole (MCTP)-induced pulmonary hypertension, pulmonary sequestration of 111In-labeled platelets in rats treated with MCTP and anti-rat platelet serum (PAS) was examined. "

Therapies and Procedures

1.	Laser Therapy (Surgery, Laser) 12/01/2012 - "Percutaneous vascular laser ablation seems to be effective for bronchopulmonary sequestration in hydropic fetuses. " 01/01/2023 - "Successful Elective Thoracoscopic Resection of Complicate Extralobar Bronchopulmonary Sequestration after Intrafoetal Vascular Laser Ablation: The Paediatric Surgeon's Point of View." 01/01/2021 - "Antenatal Management of Bronchopulmonary Sequestration by Intrafetal Vascular Laser Ablation under Ultrasound Control: Narrative Review of the Literature and Report of Three Cases." 01/01/2018 - "Thoracic Changes after Full Laser Ablation of the Feeding Artery in Fetuses with Bronchopulmonary Sequestration." 01/01/2017 - "Percutaneous laser ablation of the feeding vessel in pulmonary sequestration or hybrid lesions."
2.	Laparotomy 01/01/2013 - "Emergency laparotomy helped the resection of an intralobar pulmonary sequestration with haemorrhagic shock."
3.	Thoracotomy 09/01/2013 - "This study aims to evaluate the effectiveness of video-assisted thoracic surgery for the treatment of pulmonary sequestration in a larger series compared with posterolateral thoracotomy. " 01/01/2023 - "Video-assisted thoracic surgery versus thoracotomy for treatment of patients with pulmonary sequestration: A systematic review and meta-analysis." 02/01/2019 - "Until now, the traditional procedure to treat intralobar pulmonary sequestration (ILS) in adults has been a lobectomy performed by open thoracotomy. " 09/01/2018 - "Diagnosis of pulmonary sequestration was made and left lateral muscle sparing thoracotomy was planned. " 05/18/2018 - "Pulmonary sequestration is a rare congenital pulmonary dysplasia, which requires surgical resection (either via open thoracotomy or video-assisted thoracoscopic surgery [VATS] or via endoluminal occlusion of the abnormal feeding vessel). "
4.	Therapeutics 09/01/2016 - "[Management of the Therapy of Pulmonary Sequestration: A Retrospective Multicentre Study]." 01/01/2022 - "Thus, CTA could help identify the abnormal blood vessels, and interventional therapy may be an effective alternative to surgery of pulmonary sequestration." 06/01/2021 - "Combined surgical therapy for pulmonary sequestration and aberrant artery from the abdominal aorta." 11/01/2016 - "Standard therapy regimen for pulmonary sequestration includes surgery. " 04/01/2010 - "Prenatal interventional and postnatal surgical therapy of extralobar pulmonary sequestration."
5.	Fetal Therapies (Fetal Therapy) 04/01/1999 - "Direct intrauterine fetal therapy in a case of bronchopulmonary sequestration associated with non-immune hydrops fetalis." 01/01/2019 - "The aim of this study is to evaluate long-term neurodevelopmental and respiratory outcome after fetal therapy for fetal pleural effusion, congenital cystic adenomatoid malformation, and bronchopulmonary sequestration. "