Bronchopulmonary Sequestration (Pulmonary Sequestration)

A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.

Also Known As:

Networked: 232 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Edema
2.	Shock
3.	Bronchogenic Cyst
4.	Congenital Cystic Adenomatoid Malformation of Lung (Cystic Adenomatoid Malformation of Lung)
5.	Cysts

Experts

1.	Ruano, Rodrigo: 3 articles (12/2012 - 12/2004)
2.	Dumez, Y: 3 articles (10/2011 - 02/2005)
3.	Farmer, Diana L: 3 articles (01/2008 - 01/2004)
4.	Dommergues, M: 3 articles (11/2006 - 03/2003)
5.	Zugaib, Marcelo: 2 articles (12/2012 - 09/2007)
6.	Oepkes, D: 2 articles (09/2009 - 04/2007)
7.	Lopriore, E: 2 articles (09/2009 - 04/2007)
8.	Klumper, F J C M: 2 articles (09/2009 - 04/2007)
9.	Adzick, N Scott: 2 articles (06/2009 - 01/2006)
10.	Nobuhara, Kerilyn K: 2 articles (01/2008 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bronchopulmonary Sequestration:

1.	p38 Mitogen-Activated Protein KinasesIBA 12/01/2006 - "Topical p38 MAPK inhibition resulted in significantly less pulmonary inflammatory response via reduction of pulmonary neutrophil sequestration, pulmonary cytokine expression, and a significant reduction in pulmonary microvascular injury and edema formation. "
2.	Congenital lobar emphysemaIBA 01/01/2011 - "Intralobar pulmonary sequestration masquerading as congenital lobar emphysema." 01/15/2006 - "Other lung lesions, bronchopulmonary sequestration (BPS), hybrid lesions involving both malformations, congenital lobar emphysema (CLE), are briefly included as differential diagnosis options. " 12/01/2005 - "For congenital lobar emphysema, and some pulmonary sequestrations or small cystic adenomatoid malformations (<3 cm), conservative attitude may be preferred. " 09/01/2005 - "A case of congenital lobar emphysema associated with pulmonary sequestration, presenting with respiratory distress in infancy, is reported. " 12/01/2014 - "Majority of these cystic lesions comprise congenital cystic adenomatoid malformations, pulmonary sequestrations, congenital lobar emphysema, and bronchogenic cysts. "
3.	Muromonab-CD3 (Muromonab CD3)FDA Link 01/01/1994 - "In the present study the consequences of administration of low-dose (0.5 mg) OKT3 for respiratory side-effects and pulmonary sequestration of labelled granulocytes are compared with the known effects of 5 mg OKT3. " 05/01/1993 - "Therefore, we studied complement activation in relation to activation and pulmonary sequestration of neutrophils during antirejection treatment with OKT3. " 05/01/1993 - "Respiratory side effects that sometimes occur during treatment with anti-CD3 MAb OKT3 might result from pulmonary sequestration of activated neutrophils. " 05/01/1993 - "In five studied patients treated with OKT3, pulmonary sequestration of radiolabeled granulocytes was observed from 3 until 15 minutes after the first dose of OKT3, together with peripheral blood granulocytopenia, which lasted at least 30 minutes. " 05/01/1993 - "In conclusion, we demonstrate a simultaneous activation of complement and pulmonary sequestration of activated granulocytes immediately following the first dose of OKT3. "
4.	BariumIBA 02/01/2012 - "Computerized axial tomography scan and barium swallowing study were performed, revealing a suspected intralobar pulmonary sequestration associated with sliding gastric hernia. " 10/01/1976 - "Hiatal hernia should be ruled out by barium swallow; acute pulmonary abscess by the lack of a history suggestive of a necrotizing pneumonia; bronchiectasis by bronchogram; and intralobar bronchopulmonary sequestration should be confirmed by aortography."
5.	MX1520IBA 06/01/2004 - "Studies using transgenic sickle mice, which nearly exclusively develop pulmonary sequestration upon exposure to hypoxia, showed that oral administration of MX-1520 prior to hypoxia exposure significantly reduced the percentage of sickled cells in the blood. "
6.	1- methyl- 4- cyclohexyl- 1,2,3,6- tetrahydropyridineIBA 06/15/1989 - "To study the role of platelets in monocrotaline pyrrole (MCTP)-induced pulmonary hypertension, pulmonary sequestration of 111In-labeled platelets in rats treated with MCTP and anti-rat platelet serum (PAS) was examined. "
7.	streptococcal polysaccharide type III group BIBA 01/01/1993 - "Histological studies have demonstrated that GBS toxin induces a strong inflammatory response in the lung, with pulmonary sequestration of granulocytes and extensive capillary endothelial damage. "
8.	monocrotaline pyrroleIBA 06/15/1989 - "To study the role of platelets in monocrotaline pyrrole (MCTP)-induced pulmonary hypertension, pulmonary sequestration of 111In-labeled platelets in rats treated with MCTP and anti-rat platelet serum (PAS) was examined. "
9.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 05/01/2014 - "Extralobar pulmonary sequestration is a congenital lung malformation characterized by a non-functional lung segment with systemic feeding vessel. " 01/01/2014 - "3D CTA images can provide an aberrant vessel anatomy map for the surgeon and play a decisive role in the detection of pulmonary sequestration. " 01/01/2014 - "Pulmonary sequestration with its feeding vessel originating from the proximal right coronary artery." 10/01/2013 - "An aortic feeding vessel was identified in each case and thus a bronchopulmonary sequestration (BPS) was suspected. " 08/01/2013 - "His computed tomography scan showed a dense lesion in the left lower lobe with a feeding vessel arising from the abdominal aorta, characteristic for an intra-pulmonary sequestration. "
10.	Congenital diaphragmatic herniaIBA 07/01/2015 - "However, the combined association of congenital diaphragmatic hernia with both pulmonary sequestration and malrotation of gut is rare. " 12/01/2014 - "Congenital diaphragmatic hernia with associated pulmonary sequestration." 09/01/2014 - "Extralobar pulmonary sequestration (EPS) can occasionally be found incidentally in congenital diaphragmatic hernia (CDH). " 09/01/2014 - "A case of congenital diaphragmatic hernia with intradiaphragmatic pulmonary sequestration: case report and literature review." 06/01/2012 - "We describe two cases of postnatally diagnosed congenital diaphragmatic hernia (CDH) combined with pulmonary sequestration, both of which were diagnosed as isolated pulmonary sequestration on prenatal ultrasound. "

Therapies and Procedures

1.	Laser Therapy (Surgery, Laser) 12/01/2012 - "Percutaneous vascular laser ablation seems to be effective for bronchopulmonary sequestration in hydropic fetuses. " 11/01/2015 - "Fetal laser surgery prevents fetal death and avoids the need for neonatal sequestrectomy in cases with bronchopulmonary sequestration." 10/01/2014 - "Bronchopulmonary sequestration with massive pleural effusion: pleuroamniotic shunting vs intrafetal vascular laser ablation." 09/01/2007 - "Percutaneous intrauterine laser ablation of the abnormal vessel in pulmonary sequestration with hydrops at 29 weeks' gestation."
2.	Laparotomy 01/01/2013 - "Emergency laparotomy helped the resection of an intralobar pulmonary sequestration with haemorrhagic shock."
3.	Thoracotomy 09/01/2013 - "This study aims to evaluate the effectiveness of video-assisted thoracic surgery for the treatment of pulmonary sequestration in a larger series compared with posterolateral thoracotomy. " 01/01/2015 - "Thoracotomy surgery was done and the patient was finally diagnosed to be extralobar pulmonary sequestration. " 08/01/2014 - "VATS resection for pulmonary sequestration is feasible and effective as an alternative to bilateral thoracotomies, in the setting of extensive preoperative planning and performance by an experienced thoracoscopic surgeon." 01/01/2014 - "Lobectomy via open thoracotomy has long been the procedure of choice for the resection of pulmonary sequestration. " 09/01/2013 - "The files of 42 patients with pulmonary sequestration treated via video-assisted thoracic surgery (18 cases) and posterolateral thoracotomy (24 cases) between September 2005 and May 2012 from a single institute were retrospectively reviewed. "
4.	Oral Administration 06/01/2004 - "Studies using transgenic sickle mice, which nearly exclusively develop pulmonary sequestration upon exposure to hypoxia, showed that oral administration of MX-1520 prior to hypoxia exposure significantly reduced the percentage of sickled cells in the blood. "
5.	Ligation 09/01/2015 - "Differentiation of anomalous systemic artery to the left lower lobe (ASALLL) from pulmonary sequestration (PS) is essential, as ASALLL can be corrected by anastomosis, embolization, or ligation of the anomalous artery. " 04/01/2014 - "Pulmonary sequestration (PS) has been treated for many years with conventional surgical removal of the ectopic lung tissue and ligation of aberrant vessels that arise from the aorta. " 09/01/2010 - "Pulmonary sequestrations have been conventionally treated surgically with removal of the tissue mass and ligation of its feeding vessels. " 08/01/2007 - "[Video-assisted thoracoscopic surgery for ligation of anomalous systemic arterial supply to pulmonary sequestration]." 11/01/2006 - "We report a case of pulmonary sequestration treated by ligature of the anomalous artery without pulmonary resection. "