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Bretylium Tosylate (Bretylium Tosilate)

Subscribe to New Research on Bretylium Tosylate

An agent that blocks the release of adrenergic transmitters and may have other actions. It was formerly used as an antihypertensive agent, but is now proposed as an anti-arrhythmic.

Also Known As:

Bretylium Tosilate; Bretylol; Bretylate; Du Pont Brand of Bretylium Tosilate; GlaxoSmithKline Brand of Bretylium Tosilate; Ornid; Benzenemethanaminium, 2-bromo-N-ethyl-N,N-dimethyl-, salt with 4-methylbenzenesulfonic acid (1:1)

Networked: 101 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Quaternary Ammonium Compounds: 1159
    - Benzylammonium Compounds
      - Bretylium Compounds
        Bretylium Tosylate: 101
        4-azidobretylium tosylate
- Onium Compounds
  - Quaternary Ammonium Compounds: 1159
    - Bretylium Compounds
      - Bretylium Tosylate: 101
        4-azidobretylium tosylate

Experts

1.	Devseren, E: 1 article (01/2007)
2.	Cakir, B: 1 article (01/2007)
3.	Kasimay, O: 1 article (01/2007)
4.	Yeğen, B C: 1 article (01/2007)

Related Diseases

1.	Ventricular Fibrillation 11/01/1990 - "Bretylium tosylate has been shown effective in the treatment of ventricular fibrillation and in the prevention of its recurrence. " 04/01/1984 - "Bretylium tosylate may provide life-saving therapy for refractory prehospital ventricular fibrillation so that survival from an almost uniformly fatal condition is improved. " 10/01/1986 - "Use of bretylium tosylate as prophylaxis and treatment in hypothermic ventricular fibrillation in the canine model." 12/01/1984 - "Bretylium tosylate for ventricular fibrillation in a child." 04/01/1984 - "Among 218 patients treated for prehospital arrest during an eight-month baseline period prior to addition of bretylium tosylate to the paramedic protocol in Columbus, 16 (7.3%) were seen with refractory ventricular fibrillation (RVF). "
2.	Cardiac Arrhythmias (Arrythmia) 10/31/1988 - "[Bretylium tosylate in the treatment and prevention of ventricular arrhythmia: a new look at an old drug]." 06/15/1973 - "[Bretylium Tosylate in the therapy of malignant arrhythmia. " 09/15/1971 - "[Value of bretylium tosylate in controlling arrhythmia]." 02/01/1971 - "[Bretylium tosilate in cardiac arrhythmia therapy]." 10/01/1986 - "We conducted a study to determine if bretylium tosylate (BT) is effective in the prophylaxis and treatment of hypothermic ventricular fibrillation (VF) in the setting of various maneuvers thought to induce this lethal arrhythmia. "
3.	Ventricular Tachycardia 01/01/1999 - "Efficacy of bretylium tosylate for ventricular tachycardia." 08/01/1987 - "[Treatment of refractory ventricular tachycardia and fibrillation by bretylium tosylate: a report of 4 cases]." 07/30/1984 - "In treating ventricular tachycardia, bretylium tosylate is generally given 5 to 10 mg/kg i.v. over 10 to 20 minutes. " 06/01/1983 - "We used programmed ventricular stimulation to test intravenous bretylium tosylate in 10 consecutive patients with inducible sustained ventricular tachycardia (usually refractory to type I antiarrhythmic agents). " 06/01/1983 - "Electrophysiologic testing of bretylium tosylate in sustained ventricular tachycardia."
4.	Myocardial Infarction 05/01/1970 - "The prophylactic value of parenterally administered bretylium tosylate against the onset of dysrhythmias after acute myocardial infarction has been assessed by a controlled trial in 101 male patients. " 10/05/1992 - "No evidence of the effectiveness of bretylium tosylate on atrio-ventricular conduction and hemodynamic complications of myocardial infarction was found." 10/05/1992 - "Therefore, bretylium tosylate should be administrated to patients with the acute myocardial infarction in combination with other rapidly acting anti-arrhythmic drug. " 10/05/1992 - "It was found that bretylium tosylate reduces the incidence of ventricular arrhythmias accompanying myocardial infarction but after 2-3 hours following its administration (p < 0.05). " 10/05/1992 - "[The effect of bretylium tosylate on ventricular arrhythmias in patients with acute myocardial infarction]."
5.	Ischemia 03/01/1989 - "Ischemia-induced conduction delay and ventricular arrhythmias: comparative electropharmacology of bethanidine sulfate and bretylium tosylate." 07/01/1986 - "Experimental and clinical studies demonstrate the antifibrillatory effectiveness of bretylium tosylate: Experimental ventricular fibrillation induced either by electrical stimulation or by ischemia is prevented by bretylium. " 07/01/1989 - "Quinidine hydrochloride 10 mg kg-1 (n = 10) or bretylium tosylate 20 mg kg-1 (n = 10) administered 15 min prior to coronary artery occlusion reduced the incidence of ischemia-induced ventricular fibrillation to 10% compared with 60% in controls (n = 15). "

Related Drugs and Biologics

1.	Lidocaine (Xylocaine)
2.	bretylium
3.	Bethanidine (Batel)
4.	Quinidine (Chinidin)
5.	Guanethidine
6.	Cholecystokinin A Receptor
7.	Leptin
8.	Devazepide
9.	Sodium
10.	Insulin Receptor

Related Therapies and Procedures

1.	Resuscitation
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Lower Body Negative Pressure
5.	Injections