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Breast Diseases (Breast Disease)

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Pathological processes of the BREAST.

Also Known As:

Breast Disease; Diseases, Breast; Endocrine Breast Diseases; Breast Disease, Endocrine; Breast Diseases, Endocrine; Disease, Breast; Disease, Endocrine Breast; Diseases, Endocrine Breast; Endocrine Breast Disease

Networked: 1088 relevant articles (34 outcomes, 148 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 8226
  - Breast Diseases: 1088

Related Diseases

1.	Breast Neoplasms (Breast Cancer)
2.	Endometrial Neoplasms (Endometrial Cancer)
3.	Ovarian Cysts (Ovarian Cyst)
4.	Pelvic Inflammatory Disease (Pelvic Inflammatory Diseases)
5.	Ovarian Neoplasms (Ovarian Cancer)

Experts

1.	Colditz, Graham A: 11 articles (08/2015 - 02/2004)
2.	Willett, Walter C: 8 articles (08/2015 - 07/2004)
3.	Tamimi, Rulla M: 7 articles (08/2015 - 01/2010)
4.	Schnitt, Stuart J: 6 articles (01/2015 - 06/2003)
5.	Rohan, Thomas E: 6 articles (06/2014 - 08/2003)
6.	Page, David L: 6 articles (06/2014 - 04/2008)
7.	Berkey, Catherine S: 5 articles (08/2015 - 05/2012)
8.	Connolly, James L: 5 articles (01/2015 - 07/2004)
9.	Shriver, Craig D: 5 articles (12/2012 - 11/2004)
10.	Rosner, Bernard: 4 articles (01/2015 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Breast Diseases:

1.	Oral ContraceptivesIBA 07/01/1982 - "Studies have documented the protective effects of oral contraceptives (OCs) against 5 diseases: 1) OCs prevent 50-75% of potential cases of benign breast disease; there is an estimated annual reduction of 235 hospitalized cases for every 100,000 U.S. " 08/01/1977 - " In a large study in the Boston area, the risk of benign breast disease for pill users was .4. It appears that women with no history of oral contraceptives have a greater risk of developing benign breast disease. " 08/01/1977 - " Since the use of oral contraceptives is very high in young women, existing studies were reviewed to discover the association between oral contraceptives and benign breast disease. " 02/01/2012 - "Most papers have reported that oral contraceptives protect against benign breast disease, whereas some others have suggested that effects of pill are not yet fully clear. " 12/01/2007 - "Oral contraceptives and benign breast disease: an update of findings in a large cohort study."
2.	Tamoxifen FDA LinkGeneric 02/19/2003 - "Women in this study who received tamoxifen, especially younger women (i.e., <50 years), had a reduced incidence of clinically detected benign breast disease and underwent fewer breast biopsies." 07/01/2011 - "There were no cases, either among those with breast disease or those without, where cells consistent with breast disease were seen, nor were "tamoxifen cells" identified, on Pap testing. " 11/01/2006 - "Tamoxifen also reduced the incidence of benign breast disease as well as the number of breast biopsies in the treated women. " 02/19/2003 - "Overall, tamoxifen treatment reduced the risk of benign breast disease by 28% (RR = 0.72, 95% confidence interval [CI] = 0.65 to 0.79). " 02/19/2003 - "We examined the effect of tamoxifen treatment on the incidence of benign breast disease and the number of breast biopsies in the same group of women. "
3.	HormonesIBA 02/01/2012 - "The data on the effect of steroid hormones on benign breast disease come from observational studies with several potential bias. " 12/01/2009 - "Inverse probability weighting led to small changes in effects of benign breast disease, family history, and hormone therapy. " 05/01/2009 - "Controls were women not known to have any breast disease or hormone-related tumours. " 03/01/2007 - "Physician records for an additional 126 case patients and 90 control participants not reporting hormone therapy but reporting oral contraceptive use or benign breast disease were also obtained. " 11/15/2000 - "Reproductive risk factors, benign breast disease, use of postmenopausal hormones, weight, and alcohol intake were evaluated as risk factors. "
4.	Biological Markers (Surrogate Marker)IBA 05/01/2008 - "These changes may constitute novel biomarkers or reveal novel treatment modalities that could inhibit progression from primary to metastatic breast disease." 08/01/2012 - "In the present study, we investigated plasma ET-1 and Big ET-1 levels in patients with suspicious mammographic lesions, in order to assess their potential application as diagnostic biomarkers in the early estimation of breast disease. " 09/15/2006 - "Our study provides evidence supporting the potential role of serum MMP2/9 as biomarkers for breast disease classification." 12/01/2000 - "Classification of preinvasive breast disease could be better founded using biologic markers, thereby increasing reproducibility. " 05/01/2008 - "Because it is independently related to a personal history of benign or malignant breast disease and to predicted breast cancer risk, it may have value for breast cancer risk stratification and as a surrogate endpoint marker in prevention trials."
5.	Danazol (Azol)FDA LinkGeneric 01/01/1995 - "In conclusion, this study confirms that danazol offers very good therapeutic results for the treatment of the frequently persisting benign breast disease." 04/24/1982 - "Controlled trial of the antigonadotropin danazol in painful nodular benign breast disease." 01/01/2002 - "The patients with ER positive breast disease responded better to danazol than patients with ER negative breast disease." 08/01/1989 - "[Mechanism of action of danazol, personal clinical experiences and guidelines for the treatment of benign breast diseases]." 08/01/1989 - "[Danazol therapy in benign breast diseases]."
6.	Progestins (Progestagens)IBA 02/01/2011 - "In benign breast disease the use of progestogens results not only in reduction of mastodynia, but also a reduction in breast gland size and disappearance of nodularity proven by clinical examination and follow-up including breast ultrasound." 01/01/1995 - "[Gestagens and breast diseases]." 11/01/1991 - " Progestins, at least in the high doses used in early orals, protect against benign breast disease. " 01/01/1995 - "Most studies suggest that progestins are effective in the treatment of premenstrual syndrome and benign breast disease. " 06/11/1983 - "An improved knowledge of the mode of action of individual available progestins results in better management of a wide variety of clinical disorders including, amongst others, endometrial pathology, benign breast diseases, hirsutism and acne."
7.	Estrogens (Estrogen)FDA Link 11/01/2009 - "In view of the reanalyzes of the Women's Health Initiative's data that show a beneficial effect of estrogen therapy on cardiac and breast diseases in women aged 50-59 years, more definitive evidence is needed to confirm that the early initiation of estrogen therapy that is continued for a few years provides enduring protection against cognitive aging 15-20 years later." 09/01/2008 - "The results of this study suggest that the use of estrogen plus progestin may increase the risk of benign proliferative breast disease." 07/01/1988 - "Future studies should incorporate the more recently developed approaches to investigating estrogen metabolism and bioactivity, and include familial benign and malignant breast disease." 11/01/1987 - "Benign and malignant breast disease: initial study results of serum and breast fluid analyses of endogenous estrogens." 10/01/2013 - "There was a significant association between metastatic ovarian masses and stage III to IV breast disease (P = .00) and negative estrogen receptor status (P = .05). "
8.	AntigensIBA 01/07/2011 - "These 761 antigens were screened using an independent set of IBC sera (n = 51) and sera from women with benign breast disease (BBD) (n = 39). " 04/01/1993 - "We performed immunocytochemical staining of benign, in situ, and malignant breast disease to identify antigens related to the presence of the major parenchymal cell types of the normal breast. " 04/01/1988 - "The finding of only small foci of weak positivity for D5 antigen in normal and benign breast disease indicated that there are similarities between the expression of D5 antigen and the presence of oestrogen receptor protein in these tissues. " 03/01/1986 - "Areas of benign breast disease showed a more varied pattern of antigen expression. " 06/01/1983 - "No differences were detected between controls and patients with benign or malignant breast disease in reactivity to T- and MN-antigens. "
9.	Progesterone FDA LinkGeneric 11/01/1984 - "Earlier studies of the serum concentration of progesterone during the luteal phase in women with benign breast disease have produced conflicting results. " 01/01/1999 - "Taken together, these results suggest at least an absence of deleterious effects caused by percutaneous progesterone use in women with benign breast disease." 01/01/1999 - "Percutaneous progesterone topically applied on the breast has been proposed and widely used in the relief of mastalgia and benign breast disease by numerous gynecologists and general practitioners. " 12/01/1985 - "Although these volunteers comprised patients with benign and malignant breast disease and normal unaffected women, the relationship between salivary and blood progesterone was similar for all groups. " 11/01/1984 - "Serum progesterone concentration during the luteal phase in women with benign breast disease."
10.	alpha-Tocopherol FDA Link 05/01/1990 - "We conclude that alpha-tocopherol is not beneficial in the treatment of benign breast disease. " 01/01/1983 - "In a double-blind, randomized dose-response study, 75 women with benign breast disease were administered a written questionnaire in which they scored the severity of premenstrual syndrome (PMS) symptoms before and after two months of treatment with placebo or alpha-tocopherol (150, 300, or 600 IU/day). " 01/01/1985 - "Alpha-tocopherol (vitamin E) has been used to treat patients with benign breast disease. " 09/01/1981 - "The results suggest that alpha-tocopherol may serve as an effective agent not only to treat patients with benign breast disease but also to normalize abnormal hormone and lipid levels in subjects at high risk for breast cancer." 09/01/1981 - "Results of this study indicate that alpha-tocopherol therapy may correct an abnormal progesterone/estradiol ratio in patients with mammary dysplasia, with implications on reducing future risk for malignant breast disease."

Therapies and Procedures

1.	Contraception (Birth Control) 01/01/1995 - "Our data are in concordance with other epidemiological studies, that showed no influence on breast mitosis and apoptosis and that there was a reduced incidence of benign breast disease; we also believe that it has a beneficial effect and that this method of contraception is the best." 05/01/1982 - " Adequate control for both selection bias and confounding factors influenced by physicians' prescribing practices and the benign breast disease patients' choice of contraception has not been carried out in the majority of studies reported. " 01/01/2013 - "Furthermore, there are clinical issues unique to women, including gynaecologic and breast diseases, menopause-related factors, contraception and other topics related to women's and sexual health. " 06/01/1997 - "[Hormonal contraception and benign breast disease. " 01/01/1991 - "[Oral contraception and benign breast diseases]."
2.	Drug Therapy (Chemotherapy) 09/01/2005 - "This study aimed to evaluate patterns of local and distant disease recurrence in patients having primary chemotherapy and compared patterns of relapse in patients with a complete pathological response with those who had residual breast disease. " 08/01/2013 - "BC patients who were about to receive chemotherapy (N = 74) and patients with a benign breast disease (BBD) (N = 63) participated. " 01/01/2013 - "Patients undergoing chemotherapy or with secondary breast disease and slides with insufficient specimen were excluded. " 01/01/2012 - "Historically, neoadjuvant chemotherapy has been used to treat patients with advanced breast disease in an attempt to convert them into candidates for breast conservation surgery. " 12/01/2011 - "Patients with biopsy proven breast disease or treated with chemotherapy were excluded. "
3.	Radiotherapy 11/01/2014 - "Association with suitable chemo-radiotherapy allows a good control of breast disease. " 01/01/2003 - "Radiotherapy in early breast disease: current status and perspectives." 01/01/1992 - "At our Breast Institute at St. Vincent's Hospital where we see 100 patients with breast diseases weekly it is policy to recommend quadrantectomy, total axillary dissection and radiotherapy (QU.A.R.T.) for patients with T1 and T2 tumours if they are peripherally placed within the breast. " 11/07/2011 - "Emerging clinical applications in breast disease, cardiology, dermatology, gastroenterology, gynaecology, minimally invasive surgery, musculoskeletal studies, radiotherapy, tissue engineering, urology and vascular disease are critically discussed. " 10/01/2008 - "The highest risk of radiation- induced breast cancer is evidenced in the sub-population of female patients who have undergone radiotherapy for either malignant or non-malignant diseases, including benign breast diseases in their childhood or young age. "
4.	Lasers (Laser) 01/01/2015 - "This is the first pilot study to investigate the potential role of confocal laser imaging as a diagnostic tool in breast diseases. " 12/01/1997 - "The contrast of breast disease in an image produced by a time-domain, near-infrared laser, imaging system was calculated by use of a finite-difference method. " 01/01/2008 - "To determine whether molecular profiles can discriminate breast disease by grade, patterns and levels of allelic imbalance (AI) at 26 chromosomal regions frequently altered in breast disease were examined in 185 laser microdissected specimens representing well-differentiated (grade 1; n = 55), moderately-differentiated (grade 2; n = 71), and poorly-differentiated (grade 3; n = 59) stage I-IV breast tumors. " 11/01/2004 - "We used laser-assisted microdissection of paraffin-embedded breast tissues from 30 patients with breast disease and a panel of 52 microsatellite markers defining 26 chromosomal regions to characterize genomic patterns of allelic imbalance (AI) in disease-free tissue adjacent to sites of breast disease and to define genomic regions that may contain genes associated with early carcinogenic processes. "
5.	Fat-Restricted Diet (Diet, Fat Restricted) 03/01/1994 - "Between 1990 and 1993, we conducted a prospective cohort study to find out the efficacy of a low fat diet (less than 15% fat-derived calories) in the treatment of benign breast disease in patients who had been symptomatic for 6 months or more. " 03/01/1994 - "Efficacy of low fat diet in the treatment of benign breast disease." 03/01/1994 - "A low fat diet improves the symptoms as well as the lipid profile in patients with benign breast disease."