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Metabolic Brain Diseases (Encephalopathy, Metabolic)

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Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.

Also Known As:

Encephalopathy, Metabolic; Brain Diseases, Metabolic; Acquired Metabolic Diseases, Brain; Acquired Metabolic Diseases, Nervous System; Acquired Metabolic Encephalopathies; Brain Diseases, Metabolic, Acquired; Brain Disorders, Metabolic; Brain Disorders, Metabolic, Acquired; Brain Syndrome, Metabolic; Brain Syndrome, Metabolic, Acquired; CNS Metabolic Disorders; CNS Metabolic Disorders, Acquired; Encephalopathy, Metabolic, Acquired; Metabolic Brain Diseases, Acquired; Metabolic Brain Syndrome; Metabolic Brain Syndrome, Acquired; Metabolic Brain Syndromes; Metabolic Brain Syndromes, Acquired; Metabolic Diseases, Acquired, Nervous System; Metabolic Disorder, Central Nervous System, Acquired; Metabolic Disorders, CNS; Metabolic Disorders, CNS, Acquired; Metabolic Disorders, Central Nervous System; Metabolic Encephalopathies; Nervous System Acquired Metabolic Diseases; Acquired Metabolic Encephalopathy; Brain Disease, Metabolic; Brain Disorder, Metabolic; Brain Metabolic Disorder; Brain Metabolic Disorders; CNS Metabolic Disorder; Encephalopathies, Acquired Metabolic; Encephalopathy, Acquired Metabolic; Metabolic Brain Disease; Metabolic Brain Disorder; Metabolic Brain Disorders; Metabolic Disorder, Brain; Metabolic Disorder, CNS; Metabolic Encephalopathies, Acquired; Metabolic Encephalopathy; Metabolic Encephalopathy, Acquired; Central Nervous System Metabolic Disorders; Encephalopathies, Metabolic; Metabolic Disorders, Brain

Networked: 133 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fibrosis (Cirrhosis)
2.	Hypothyroidism
3.	Brain Edema (Cerebral Edema)
4.	Seizures (Seizure)
5.	Hyperammonemia

Experts

1.	Lee, Sang Kun: 2 articles (01/2013 - 12/2012)
2.	Moran, Robert R: 2 articles (01/2013 - 01/2010)
3.	Jung, Keun-Hwa: 2 articles (01/2013 - 12/2012)
4.	Abramson, Ruth K: 2 articles (01/2013 - 01/2010)
5.	Chu, Kon: 2 articles (01/2013 - 12/2012)
6.	Cuturic, Miroslav: 2 articles (01/2013 - 01/2010)
7.	Hardin, James W: 2 articles (01/2013 - 01/2010)
8.	Lee, Soon-Tae: 2 articles (01/2013 - 12/2012)
9.	Jallon, Pierre: 2 articles (06/2009 - 01/2002)
10.	El Beltagi, Ahmed: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Metabolic Brain Diseases:

1.	Glucose Transporter Type 1IBA 07/01/2011 - "Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is a metabolic encephalopathy that can be effectively treated with a ketogenic diet. " 01/01/2014 - "Glucose transporter type 1 deficiency syndrome is a metabolic encephalopathy that results from impaired glucose transport into the brain as the result of a mutation of the SLC2A1 gene. "
2.	Nucleic AcidsIBA 12/01/2013 - "Synthetic nucleic acids delivered by exosomes: a potential therapeutic for generelated metabolic brain diseases."
3.	BenzodiazepinesIBA 07/01/2001 - "Rhythmic sharp waves resulting from metabolic encephalopathy are abolished by benzodiazepines, similar to NCSE, but without improvement in mental status. " 07/01/2001 - "They retrospectively identified patients with TW resulting from metabolic encephalopathy who had EEG recordings before, during, and after benzodiazepine administration. " 07/01/2001 - "The authors hypothesized that triphasic waves (TW) resulting from metabolic encephalopathy are abolished by benzodiazepines. "
4.	Carnitine (L-Carnitine)FDA LinkGeneric 01/01/2010 - "Metabolic encephalopathy is one of the crucial manifestations of carnitine deficiency. " 11/01/1989 - "L-Carnitine was tested as a potential therapeutic agent, since it has been used to treat a variety of experimental metabolic encephalopathies. " 09/17/1984 - "L-carnitine: therapeutic strategy for metabolic encephalopathy." 01/01/2013 - "We hypothesize that observed improvement related to the resolution of reversible metabolic encephalopathy and myopathy associated with secondary carnitine deficiency. " 04/15/1996 - "Carnitine deficiency results in failure of energy production by mitochondria and leads to metabolic encephalopathy, lipid-storage myopathy, and cardiomyopathy. "
5.	Protons (Proton)IBA 11/01/1998 - "Proton MR spectroscopy of pediatric brain metabolic disorders." 11/01/1997 - "The value of proton MR spectroscopy in pediatric metabolic brain disease." 11/01/1996 - "Two children suffering from this metabolic brain disease were examined using image-guided localized proton spectroscopy. " 09/01/1995 - "Localized proton magnetic resonance spectroscopy of the brain differentiates the inborn metabolic encephalopathies in children." 08/01/1995 - "After a short presentation of the methods and of the metabolic signals detected by phosphorus and proton MRS of the brain, the impact of MRS in pediatrics is examined with two main indications: the study of cerebral maturation in normal or pathological neonates, and the study of inborn metabolic encephalopathies. "
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 04/01/2004 - "Clinical computed tomography (CT) and magnetic resonance imaging (MRI) studies have revealed a correlation between clinical symptoms of cyclosporine-mediated neurotoxicity and morphological changes in the brain, such as hypodensity of white matter, cerebral edema, metabolic encephalopathy, and hypoxic damages. " 08/01/1989 - "Post-transplant seizures, occurring in a third of the patients, were related to a variety of causative factors such as sepsis, intracranial hemorrhage, cerebral ischemia, metabolic encephalopathy and cyclosporin neurotoxicity. "
7.	HormonesIBA 03/01/2000 - "Hormone studies and nuclear magnetic resonance imaging revealed hypophysitis, which led to hypothyroidism and metabolic encephalopathy. " 10/01/1989 - "Thus, certain metabolic encephalopathies or the carcinoid myopathy are due to production of hormones or hormonelike substances by the tumor. "
8.	PyrimidinesIBA 01/01/1993 - "Cerebrospinal fluid amino acids, purines and pyrimidines as a tool in the study of metabolic brain diseases."
9.	PurinesIBA 01/01/1993 - "Cerebrospinal fluid amino acids, purines and pyrimidines as a tool in the study of metabolic brain diseases."
10.	PhosphorusIBA 08/01/1995 - "After a short presentation of the methods and of the metabolic signals detected by phosphorus and proton MRS of the brain, the impact of MRS in pediatrics is examined with two main indications: the study of cerebral maturation in normal or pathological neonates, and the study of inborn metabolic encephalopathies. "

Therapies and Procedures

1.	Ketogenic Diet 07/01/2011 - "Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is a metabolic encephalopathy that can be effectively treated with a ketogenic diet. "
2.	Drug Therapy (Chemotherapy) 01/01/2003 - "[Brain metabolic disorders after chemotherapy in the study by magnetic resonance spectroscopy]." 07/01/2008 - "Viewing depression as a form of encephalopathy, and exploiting knowledge gleaned from our understanding of the neurochemistry and treatment of metabolic encephalopathy, may assist in our understanding of the neurobiology of depression, but also in realizing new ideas in the pharmacotherapy of mood disorders." 09/01/2010 - "Calcineurin inhibitor (CNI)-associated neurotoxicity was the most common CNS complication (n=16), followed by CNS infection (n=2), cerebrovascular events (n=2), thrombotic microangiopathy-associated events (n=2), metabolic encephalopathy (n=2), irradiation/chemotherapy injury (n=1), and encephalopathy/myelopathy of unknown causes (n=2). "
3.	Critical Care 06/01/2012 - "Metabolic encephalopathies in the critical care unit." 09/01/2002 - "Metabolic encephalopathies, usually multifactorial in origin, may be important complications of many diseases of patients treated in a critical care unit. " 10/01/1996 - "Metabolic encephalopathies are common among patients in the critical care unit. "
4.	Stem Cell Transplantation 09/01/2009 - "Hypercytokinemia-induced metabolic encephalopathy in a multiple myeloma patient on hemodialysis undergoing autologous stem cell transplantation: clinical response after plasma exchange." 03/13/2007 - "Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. "
5.	Intensive Care (Surgical Intensive Care) 01/01/1977 - "Intensive care was applied in 13 patients with acute liver insufficiency and different degrees of metabolic encephalopathy due to the ingestion of Amanita phalloides. " 03/01/1990 - "ICP monitoring and recording provide another important parameter in the intensive care management of many critically ill patients and have been shown to augment the clinical neurologic examination, particularly in comatose patients suffering from severe head trauma, toxic and metabolic encephalopathies, massive cerebral infarctions, and many other central nervous system insults. "