Boron

02/01/2014 - "This study demonstrated that pulsed-HIFU was beneficial to the accumulation of boron drug in the head and neck tumor lesion and may enhance the therapeutic efficacy of clinical BNCT."
02/01/1995 - "A selective boron delivery to the neoplasm is a prerequisite for successful therapy. "
06/01/2005 - "Critical issues that must be addressed include the need for more selective and effective boron delivery agents, the development of methods to provide semiquantitative estimates of tumor boron content before treatment, improvements in clinical implementation of BNCT, and a need for randomized clinical trials with an unequivocal demonstration of therapeutic efficacy. "
04/01/1985 - "A parameter of major importance is the minimum concentration of boron needed in tumor in order to produce improved results in cancer therapy. "
07/01/1989 - "A correlation between therapeutic efficacy and the ability to deliver boron to viable areas of tumor has been observed."

04/01/2000 - "These results demonstrate that using a combination of boron agents and optimizing their delivery can dramatically improve the efficacy of BNCT in glioma-bearing rats."
02/01/1993 - "In this paper we present an improved technique for neutron activated autoradiography providing quantitative boron images of freeze-sectioned tissue specimens from highly malignant rat brain gliomas. "
06/01/2011 - "Second, to determine the efficacy of H2TCP and H2TBP as boron delivery agents for BNCT in F98 glioma bearing rats. "
06/01/1958 - "[Experimental study on the possibilities of utilization of boron 10 in treatment of intracranial gliomas by capture of slow neutrons]."
12/01/2015 - "Biokinetic analysis of tissue boron ((10)B) concentrations of glioma patients treated with BNCT in Finland."

01/01/2013 - "Both in vivo and in vitro studies in melanoma models demonstrated that boron was localized in the cytoplasm and nuclei with some cell-to-cell variability. "
06/01/1994 - "This note reports on the study of the boron distribution in tissues on an animal model (nude mice) xenografted with a human ocular melanoma after an i.p.injection of 2g/kg of 10B-BPA and in cells cultured in the presence of 530 mumol/l of 10B-BPA. "
07/01/1989 - "Preclinical studies in animals show that several MAbs may bind to melanoma cells in sufficient quantities in vitro to localize the required amount of Boron per cell. "
02/01/1989 - "In vitro and in vivo studies of boron conjugated melanoma affined biochemicals."
08/01/2012 - "Moreover, at this time, the increase in boron uptake in melanoma cells was approximately 1.6 times higher than that in normal melanocytes. "

07/01/2000 - "The MEPHISTO spectromicroscope, which performs microchemical analysis by x-ray absorption near edge structure (XANES) spectroscopy from microscopic areas, has been used to study the distribution of trace quantities of boron in human brain cancer tissues surgically removed from patients first administered with the compound Na2B12H11SH (BSH). "
07/01/1999 - "The boron concentration was measured by an in vivo rat experimental brain tumor model and an in vitro cell culture study. "
06/01/2014 - "Boron concentration in subcutaneous and brain tumors was maintained for 6 and 12h after the administration of BSH following BSO pretreatment. "
07/01/2009 - "Based on these observations, we have concluded that EGFR targeting vehicles are useful, but not stand-alone boron delivery agents due to the heterogeneity of receptor expression in brain tumors. "
09/01/2005 - "The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells."

03/01/2011 - "Within the context of exploring the potential therapeutic efficacy of BNCT for the treatment of liver metastases, the aim of the present study was to perform boron biodistribution studies in an experimental model of liver metastases in rats. "
06/01/2014 - "We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. "
02/01/2011 - "To study the possibility of applying BNCT to the treatment of diffuse pulmonary tumours, an animal model for boron uptake measurements in lung metastases was developed. "
07/01/2009 - "Boron biodistribution study in colorectal liver metastases patients in Argentina."
02/01/2011 - "Also the images of boron distribution in the samples, obtained by neutron autoradiography, show a selective absorption in the metastases."