Borderline Personality Disorder (Personality Disorders, Borderline)

A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)

Also Known As:

Networked: 670 relevant articles (60 outcomes, 172 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Personality Disorders (Personality Disorder)
2.	Post-Traumatic Stress Disorders (PTSD)
3.	Depressive Disorder (Melancholia)
4.	Gambling (Pathological Gambling)
5.	Cocaine-Related Disorders (Cocaine Addiction)

Experts

1.	Zanarini, Mary C: 16 articles (11/2014 - 05/2002)
2.	Bohus, Martin: 15 articles (08/2015 - 07/2004)
3.	Roepke, Stefan: 13 articles (04/2015 - 04/2009)
4.	Lieb, Klaus: 13 articles (01/2015 - 07/2004)
5.	Schmahl, Christian: 12 articles (08/2015 - 07/2004)
6.	Bogetto, Filippo: 11 articles (03/2015 - 03/2002)
7.	Bellino, Silvio: 10 articles (03/2015 - 09/2005)
8.	Nickel, Marius K: 10 articles (06/2008 - 08/2004)
9.	Loew, Thomas H: 9 articles (06/2008 - 08/2004)
10.	Kleindienst, Nikolaus: 8 articles (11/2015 - 02/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Borderline Personality Disorder:

1.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 05/01/2002 - "The results of this study suggest that divalproex sodium may be a safe and effective agent in the treatment of women with criteria-defined borderline personality disorder and comorbid bipolar II disorder, significantly decreasing their irritability and anger, the tempestuousness of their relationships, and their impulsive aggressiveness." 11/01/1995 - "Valproate led to overall improvement in 50% of a small sample of borderline personality disorder patients who completed an 8-week open trial. " 11/01/2012 - "Efficacy of extended-release divalproex combined with "condensed" dialectical behavior therapy for individuals with borderline personality disorder." 03/01/2001 - "Since anticonvulsant agents may be helpful in such symptomatology, we compared divalproex sodium with placebo in patients with borderline personality disorder. " 06/01/2007 - "An open-label trial of divalproex extended-release in the treatment of borderline personality disorder."
2.	quetiapine (Seroquel)FDA Link 11/01/2014 - "Participants treated with 150 mg/day of quetiapine had a significant reduction in the severity of borderline personality disorder symptoms compared with those who received placebo. " 01/01/2005 - "Conclusion Quetiapine relieved symptoms of psychosis, reduced impulsivity or depressed mood and improved global functioning in patients with borderline personality disorder and psychosis. " 04/01/2007 - "Recent data indicate that quetiapine may also be effective in the treatment of bipolar depressive symptoms without increasing the risk of triggering manic episodes, and in borderline personality disorder. " 12/01/2009 - "We aimed to assess whether executive functioning improved over time in a sample of borderline personality disorder (BPD) subjects that took part in a quetiapine treatment trial. " 12/01/2009 - "Quetiapine treatment and improved cognitive functioning in borderline personality disorder."
3.	Carbon MonoxideIBA 03/01/2008 - "A randomized controlled trial was conducted to determine whether a manual-based psychodynamic treatment, labeled dynamic deconstructive psychotherapy (DDP), would be feasible and effective for individuals with co-occurring borderline personality disorder (BPD) and alcohol use disorder. " 11/01/2015 - "The aim of this study was to undertake a systematic review on effective treatment options for co-occurring substance use and borderline personality disorders to examine effective treatments for this group. " 02/01/2009 - "A controlled trial of psychodynamic psychotherapy for co-occurring borderline personality disorder and alcohol use disorder: six-month outcome." 12/01/2008 - "This study evaluated whether dialectical behavior therapy (DBT) was more efficacious than treatment by nonbehavioral psychotherapy experts in reducing co-occurring Axis I disorders among suicidal individuals with borderline personality disorder (BPD). " 12/01/2008 - "Treating co-occurring Axis I disorders in recurrently suicidal women with borderline personality disorder: a 2-year randomized trial of dialectical behavior therapy versus community treatment by experts."
4.	Antipsychotic Agents (Antipsychotics)IBA 01/01/2010 - "The current evidence from randomised controlled trials suggests that drug treatment, especially with mood stabilisers and second-generation antipsychotics, may be effective for treating a number of core symptoms and associated psychopathology, but the evidence does not currently support effectiveness for overall severity of borderline personality disorder. " 01/01/1984 - "A dramatic improvement in mood and behavior after TRH occurred during treatment with low-dose neuroleptics in a patient with major depression and borderline personality disorder. " 08/01/2011 - "Differential effectiveness of antipsychotics in borderline personality disorder: meta-analyses of placebo-controlled, randomized clinical trials on symptomatic outcome domains." 01/30/2007 - "Only a few studies have commented on the use of atypical antipsychotics for the treatment of Borderline Personality Disorder (BPD) features, including affective dysregulation and aggression. " 10/01/2005 - "Recent studies indicate that atypical neuroleptics may be safe and useful in treating many symptoms of borderline personality disorder (BPD), including impulsivity, which can constitute the core dimension of this pathology. "
5.	Carbamazepine (Tegretol)FDA LinkGeneric 04/01/1986 - "In a double-blind crossover trial, carbamazepine, an anticonvulsant with primary effects on subcortical limbic structures, decreased the severity of behavioral dyscontrol in 11 women with borderline personality disorder significantly more than placebo. " 08/01/1986 - "While carbamazepine may prove to be an effective medication for some patients with borderline personality disorder, careful attention to change in depressive symptoms is suggested." 12/01/1994 - "A trial of carbamazepine in borderline personality disorder." 03/01/2009 - "The paper presents the case report of a patient diagnosed with borderline personality disorder, treated with carbamazepine. " 02/01/1998 - "(2) Borderline personality disorder with behavioral dyscontrol responds to carbamazepine which reduces actual episodes of dyscontrol, to an antipsychotic drug and to MAOI. "
6.	topiramate (Topamax)FDA LinkGeneric 02/01/2006 - "Topiramate appears to be a safe and effective agent in the treatment in women with borderline personality disorder. " 11/01/2004 - "Topiramate appears to be a safe and effective agent in the treatment of anger in women with borderline personality disorder as defined by SCID criteria. " 03/01/2005 - "The aim of this study was to compare the efficacy of topiramate versus placebo in the treatment of aggression in men with borderline personality disorder. " 02/01/2006 - "Topiramate treatment for women with borderline personality disorder: a double-blind, placebo-controlled study." 11/01/2004 - "We conducted a double-blind, placebo-controlled study of topiramate in 29 female subjects (response rate 93.5%) meeting SCID (Structured Clinical Interview for DSM-IV) criteria for borderline personality disorder. "
7.	olanzapine (Zyprexa)FDA Link 08/01/2009 - "No significant difference between olanzapine and placebo for improvement in borderline personality disorder symptoms." 06/01/2008 - "This double-blind study examined whether olanzapine augments the efficacy of dialectical behavior therapy (DBT) in reducing anger and hostility in borderline personality disorder patients. " 10/01/2006 - "Our objective was to determine the efficacy of olanzapine on 20 patients with borderline personality disorder. " 10/01/2011 - "In this 12-week randomized double-blind placebo-controlled trial, 451 outpatients aged 18-65 years with DSM-IV borderline personality disorder received olanzapine 2.5 mg/d (n = 150), olanzapine 5-10 mg/d (n = 148), or placebo (n = 153). " 10/01/2011 - "A dose comparison of olanzapine for the treatment of borderline personality disorder: a 12-week randomized, double-blind, placebo-controlled study."
8.	Fluoxetine (Prozac)FDA LinkGeneric 02/01/1995 - "Clinical data and uncontrolled observations have suggested that fluoxetine is helpful in some patients with borderline personality disorder. " 04/01/1991 - "The findings from this work suggested efficacy for fluoxetine in treating the depressive and impulsive symptoms of refractory patients with borderline personality disorder." 01/01/1990 - "Fluoxetine trial in borderline personality disorder." 03/01/2011 - "She was diagnosed with borderline personality disorder (BPD) and started treatment with oral fluoxetine, showing a rapid decrease of impulsive behavior and anxiety from the second week with a mean dose of 80 mg/d." 11/01/2007 - "We compare the effects of 2 combined therapies, fluoxetine and interpersonal therapy (IPT) or fluoxetine and cognitive therapy (CT), on major depression in patients with borderline personality disorder (BPD). "
9.	lamotrigine (Lamictal)FDA LinkGeneric 03/01/2007 - "The patients had initial Clinical Global Impression-Severity scores of 5 or 6 and a final scores of 1 or 2, except for one patient with an initial score of 3 and a final score of 1 and one patient with an initial score of 6 and a final score of 7. Lamotrigine seems to be a safe and effective option for the treatment of patients with symptoms of affective instability associated with borderline personality disorder." 05/01/2005 - "The goal of this study was to compare the efficacy of lamotrigine versus placebo in the treatment of aggression in women meeting the criteria for borderline personality disorder (BPD). " 01/01/2015 - "Lamotrigine versus inert placebo in the treatment of borderline personality disorder: study protocol for a randomized controlled trial and economic evaluation." 09/01/2009 - "The objective of this study was to evaluate the effectiveness of lamotrigine in reducing affective instability in borderline personality disorder (BPD). " 09/01/2009 - "A preliminary study of lamotrigine in the treatment of affective instability in borderline personality disorder."
10.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/01/1995 - "A number of studies have indicated that selective serotonin reuptake inhibitors (SSRIs) are effective in reducing the symptomatology accompanying borderline personality disorder (BPD). " 03/01/2013 - "Results indicate that patients displaying greater variability in activation and using selective serotonin reuptake inhibitors have a higher probability to engage in lifetime NSSI after adjustment for depression and borderline personality disorder. " 07/01/2003 - "Selective serotonin reuptake inhibitors in women with borderline personality disorder." 12/01/2002 - "Selective serotonin reuptake inhibitors (SSRIs) are recommended for treatment of affect lability, impulsivity, and aggression in patients with borderline personality disorder. " 07/01/2001 - "Serotonin reuptake inhibitors play a decisive role in pharmacological treatment of Borderline Personality Disorder. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 02/01/1988 - "As an adjunct to psychotherapy, pharmacotherapy can produce modest but clinically important improvement in the mood and behavior of patients with borderline personality disorder. " 09/01/2008 - "There is good support for well-structured methods of psychotherapy, mainly in borderline personality disorder (BPD), but evidence for the efficacy of pharmacotherapy is weak. " 08/01/1987 - "Although many creative and articulate psychodynamic formulations of borderline personality disorder have been proposed, an initial "cognitive" approach to psychotherapy combined with pharmacotherapy can be effective in alleviating acute symptoms, and more psychodynamic approaches can be employed when the patient is better equipped to use them." 11/01/2006 - "Efficacy of pharmacotherapy against core traits of borderline personality disorder: meta-analysis of randomized controlled trials." 01/01/2010 - "Pharmacotherapy for borderline personality disorder: Cochrane systematic review of randomised trials."
2.	Day Care (Partial Hospitalization) 10/01/1999 - "Psychoanalytically oriented partial hospitalization is superior to standard psychiatric care for patients with borderline personality disorder. " 05/01/2009 - "This study describes naturalistic 3-month follow-up after discharge from a 5-day partial hospitalization dialectical behavior therapy (DBT) program for women diagnosed with borderline personality disorder (BPD). " 05/01/2008 - "This study evaluated the effect of mentalization-based treatment by partial hospitalization compared to treatment as usual for borderline personality disorder 8 years after entry into a randomized, controlled trial and 5 years after all mentalization-based treatment was complete. " 01/01/2001 - "The aim of this study was to determine whether the substantial gains made by patients with borderline personality disorder following completion of a psychoanalytically oriented partial hospitalization program, in comparison to patients treated with standard psychiatric care, were maintained over an 18-month follow-up period. " 10/01/1999 - "This study compared the effectiveness of psychoanalytically oriented partial hospitalization with standard psychiatric care for patients with borderline personality disorder. "
3.	Nursing Care 12/01/1997 - "Providing nursing care for a patient with borderline personality disorder on an acute inpatient unit: a phenomenological study." 02/01/2009 - "The informants' caring outcomes for borderline personality disorder patients were involved with interactions of the following five themes: (a) shifting from the honeymoon to chaos stage, (b) nurses' expectations for positive vs. negative outcomes, (c) practicing routine vs. individualised nursing care, (d) adequate or inadequate support from healthcare team members and (e) differences in care outcomes (satisfactory experiences, unsatisfactory experiences and superficial relationships). " 10/01/2007 - "This paper reviews the current literature on the nursing care of inpatients with borderline personality disorder (BPD). " 10/01/2007 - "Nursing care of inpatients with borderline personality disorder." 02/01/2004 - "[Nursing care for a patient with borderline personality disorder]."
4.	Aftercare (After-Treatment) 03/01/2007 - "30 patients with borderline personality disorder were assessed with self-report questionnaires to evaluate dissociation and psychopathology before and after treatment with Dialectic Behavior Therapy. " 01/01/2003 - "Specialist partial hospital treatment for borderline personality disorder is no more expensive than treatment as usual and shows considerable cost savings after treatment." 12/01/2008 - "The primary aim of the present study was to examine whether the presence of borderline personality disorder (BPD) adversely impacted on outcome 3 years after treatment among women with bulimia nervosa (BN), in comparison to those women with either other personality disorders (other PD) or no personality disorder (no PD). "
5.	Surgical Instruments (Clip) 12/30/2012 - "The present study wanted to test the course of the urge for non-suicidal self-injury (UNSSI) and the urge for self-punishment (USP) when suppressing or accepting upcoming emotions in response to a sadness-inducing film clip in female participants with borderline personality disorder (BPD). "