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Bone Cysts (Bone Cyst)

Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.

Also Known As:

Bone Cyst; Ganglia, Intra-Osseous; Ganglion, Intra-Osseous; Intra-Osseous Ganglia; Intra-Osseous Ganglion; Cyst, Bone; Cyst, Solitary; Cyst, Subchondral; Cysts, Bone; Cysts, Solitary; Cysts, Subchondral; Ganglia, Intra Osseous; Ganglias, Intra-Osseous; Ganglias, Intraosseous; Ganglion, Intra Osseous; Ganglion, Intraosseous; Ganglions, Intra-Osseous; Intra Osseous Ganglia; Intra Osseous Ganglion; Intra-Osseous Ganglias; Intra-Osseous Ganglions; Intraosseous Ganglia; Intraosseous Ganglias; Intraosseous Ganglions; Solitary Cyst; Subchondral Cyst; Ganglia, Intraosseous; Intraosseous Ganglion; Solitary Cysts; Subchondral Cysts

Networked: 427 relevant articles (20 outcomes, 36 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Bone Cysts (Bone Cyst)
2.	Spontaneous Fractures (Pathological Fracture)
3.	Cysts
4.	Neoplasms (Cancer)
5.	Spinal Stenosis (Stenosis, Spinal)

Experts

1.	Satoh, Jun-Ichi: 5 articles (12/2015 - 08/2011)
2.	Ishida, Tsuyoshi: 4 articles (12/2015 - 08/2011)
3.	Arima, Kunimasa: 4 articles (12/2015 - 08/2011)
4.	Jinnai, Kenji: 4 articles (12/2015 - 08/2011)
5.	Yagishita, Saburo: 4 articles (12/2015 - 08/2011)
6.	Arai, Nobutaka: 4 articles (12/2015 - 08/2011)
7.	Saito, Yuko: 3 articles (12/2015 - 04/2012)
8.	Tabunoki, Hiroko: 3 articles (04/2012 - 08/2011)
9.	Motohashi, Nobutaka: 2 articles (12/2015 - 01/2014)
10.	Nakamagoe, Kiyotaka: 2 articles (12/2015 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bone Cysts:

1.	methylprednisolone acetate (Depo-Medrol)FDA LinkGeneric 01/01/1984 - "Contrast examination was helpful in predicting the response of solitary bone cysts to treatment by injection of methylprednisolone-acetate (MPA). " 01/01/2014 - "The only included trial was a multicentre randomised controlled trial (RCT) conducted at 24 locations in North America and India that compared bone marrow injection with steroid (methylprednisolone acetate) injection for treating simple bone cysts. " 01/01/2005 - "Thirteen children (9 boys, 4 girls; mean age 9 years; range 4 to 14 years) with simple bone cysts were treated primarily with injection of methylprednisolone acetate with the use of the two-needle technique. " 01/01/2005 - "[Treatment of simple bone cysts with methylprednisolone acetate in children]." 06/01/1999 - "Injection of radiopaque contrast into a solitary bone cyst (SBC) prior to methylprednisolone acetate (MPA) injection has been previously reported. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 04/01/1990 - "[Comparison of treatment of juvenile bone cysts using local administration of corticoids and surgical therapy]." 07/01/1982 - "[Bone cysts and their treatment with corticosteroids. " 01/01/1982 - "The treatment of unicameral or solitary bone cysts by the injection of corticosteroids." 03/01/1989 - "To be effective in treating bone cysts, intracavital injections of corticosteroids must be able to run freely over their lining membrane. " 06/01/2002 - "The treatment of unicameral bone cysts varies from open bone-grafting procedures to percutaneous injection of corticosteroids or bone marrow. "
3.	Amyloid (Amyloid Fibrils)IBA 07/01/1996 - "Amyloid bone cysts improved in four patients and SAP scans demonstrated regression of articular amyloid in eight out of nine cases. " 11/01/2001 - "The aim of this study was to investigate the predictive value of CML-Hb in the progression of DRA using computed tomography images of 2-year or 3-year follow-up periods of patients with amyloid bone cysts at the hip joint. " 07/01/1996 - "The modest radiographic improvement suggests that amyloid is mobilized more slowly in bone cysts than elsewhere or that cystic bone is remodeled poorly. " 11/01/1994 - "Amyloid bone cysts of the femoral neck. " 01/01/1990 - "Amyloid proved to be an agent for bone destruction, causing bone cysts and cortical erosions. "
4.	Polycystic liver diseaseIBA 12/01/2009 - "The average size of the solitary cysts was 11.3 cm (range 9.5-17 cm), and the polycystic liver disease was 10.6 cm (range 9.2-12.1 cm). " 10/01/2002 - "Eleven patients were treated using a laparoscopic approach; 10 patients with solitary cysts and one with adult polycystic liver disease. " 12/01/2000 - "The laparoscopic approach is indicated in patients with symptomatic or atypical benign solid tumour, giant solitary cyst and polycystic liver disease, located anteriorly on the liver. " 03/01/1999 - "Congenital cystic disease of the liver include two different entities, in the last years more frequently and easily recognized by ultrasonography or computed tomography: the simple, nonparasitic or biliary or solitary cysts of the liver and the polycystic liver disease. " 01/01/1998 - "Five patients had a solitary cyst, and two had polycystic liver disease. "
5.	1-dodecylpyridoxal (PLD)IBA 06/14/2007 - "Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. " 01/01/1996 - "After a careful review of the symptoms, 8 patients (5 with a solitary cyst and 3 with a PLD) were excluded from surgical treatment and 23 were treated by laparoscopic fenestration. " 02/01/1994 - "After a careful review of the symptoms, 6 patients were excluded from surgical treatment and 11 (4 solitary cysts and 7 PLD) were treated by laparoscopic fenestration. " 01/01/2000 - "The median length of hospital stay was 1.3 days (range, 1-3 days), 3 days (range, 2-7 days), and 5 days (range, 2-17 days) for solitary cyst, PLD, and hydatid cysts, respectively. " 01/01/1996 - "31 patients were observed between November 1990 and October 1995: 15 with solitary cysts and 16 with policystic liver disease (PLD). "
6.	GadoliniumIBA 09/01/1999 - "Gadolinium-enhanced MRI, which revealed the network-like enhancement of the rim of the lesion and polycystic lesions adjacent to the joint, was helpful in making a diagnosis of intraosseous ganglion."
7.	CollagenIBA 11/01/2012 - "Enzymatically deantigenated equine bone and an equine collagen membrane were used to restore a bone defect caused by the removal of a bone cyst in the upper anterior maxilla. " 08/01/2012 - "The occurrence of sub-chondral bone cysts was lower for the collagen-GAG scaffold with an incidence of 17% of defects, compared to 67% for the PLGA material at 26 weeks. " 10/01/2015 - "The aim of this study was to investigate the use of a novel collagen-hydroxyapatite (CHA) bone graft substitute in the clinical treatment of a mandibular bone cyst in a young horse and to assess its potential to enhance repair of the affected bone. " 01/01/2001 - "Histopathological examination of the cyst wall revealed thin fibrous tissue formed of collagen fibers without a lining cell layer, with scattered lymphocytes, histiocytes, irregular masses of fibrin-like material, and periosteal osteocartilagenous callus formation; a picture compatible with simple bone cysts. " 01/01/2005 - "In order to define the histogenesis of bone solitary cyst it was performed immunohistochemical study of surgical material obtained from 17 patients with the monoclonal antibodies against the following antigens: CD-31 (marker of endotheliocytes), IV type collagen (marker of blood vessel basal membrane), vimentin (marker of connective tissue) and Ki-67 (marker of mitotic cell). "
8.	TitaniumIBA 01/01/2015 - "Treatment of a unicameral bone cyst in a dog using a customized titanium device." 05/01/2004 - "Titanium elastic nail--a useful instrument for the treatment of simple bone cyst." 08/01/2010 - "Titanium intramedullary nailing for treatment of simple bone cysts of the long bones in children." 09/01/2004 - "Nine unicameral bone cysts of the calcaneus in children were managed surgically using the technique of continuous decompression with titanium cannulated cancellous screws. " 08/01/2010 - "The objective of the present study was to evaluate the results of titanium intramedullary nailing for the treatment of unicameral bone cysts with or without a pathological fracture. "
9.	SteroidsIBA 03/01/2009 - "A randomized prospective trial of marrow-versus-steroids treatment of solitary bone cyst was ongoing. " 09/01/1981 - "Radiographic changes in unicameral bone cysts following direct injection of steroids: a report on 14 cases." 03/01/1979 - "Injection of steroids will largely replace surgery in the treatment of benign bone cysts." 03/01/1979 - "The treatment of bone cysts with intracyst injection of steroids. " 10/01/2008 - "For unicameral bone cysts requiring retreatment (regardless of first treatment), 76% retreated with steroids had failed treatment versus 63% with curettage and 71% with SDB. "
10.	Methylprednisolone FDA LinkGeneric 04/01/2008 - "Although the rate of healing of simple bone cysts was low following injection of either bone marrow or methylprednisolone, the latter provided superior healing rates." 04/01/2002 - "Unicameral bone cysts treated by injection of bone marrow or methylprednisolone." 12/01/1982 - "[Treatment of bone cysts with methylprednisolone instillation]." 03/01/2010 - "1. An association between solitary cyst volume and recurrence in patients treated with either bone curettage and grafting or methylprednisolone was not found. " 01/01/2011 - "The purpose of this study was to compare the outcome of percutaneous curettage with intralesional injection of methylprednisolone and bone marrow for unicameral bone cysts (UBCs). "

Therapies and Procedures

1.	Curettage 01/01/2004 - "The aim of the study was to evaluate the long-term results of using the bioactive, glass-ceramic material BAS-0 for bone tissue replacement after removal of juvenile bone cysts by curettage. " 02/01/2015 - "Engineering of human bone with Plexur M™ in acetabular roof reconstruction after curettage of a giant aggressive aneurismal bone cyst of the left emypelvis." 10/01/2014 - "Surgical management of the buccal bifurcation cyst: bone grafting as a treatment adjunct to enucleation and curettage." 03/01/2013 - "This report shows an atypical simple bone cyst occurring in the mandibular condyle showing recurrence after surgical curettage. " 12/01/2011 - "Simple calcaneal bone cysts: a pilot study comparing open versus endoscopic curettage and grafting."
2.	Injections 12/15/2012 - "Our results suggested that an autogenous bone marrow injection is a safe and effective treatment method for simple bone cysts, when compared with the surgical management, but sometimes-repeated injections are necessary. " 10/01/2009 - "Our results suggested that autogenous bone marrow injection is a safe and effective treatment method for simple bone cysts, but sometimes repeated injections are necessary. " 09/01/2006 - "Percutaneous injection of autogenous bone marrow is a safe and effective method to treat simple bone cyst, but repeated injections is necessary for some patients. " 11/01/2012 - "The aim of this study was to determine the benefits of cystography in the management of a simple bone cyst, its implication in the final result of the treatment after corticoid intracystic injections, and the presence of secondary effects. " 01/01/2005 - "The aim of this study was to evaluate the results of steroid injections in the treatment of simple bone cysts. "
3.	Homologous Transplantation (Allograft) 08/01/2005 - "Allograft of lyophilized cancellous bone is an effective treatment for adult unicameral bone cysts." 10/01/2012 - "In the present clinical study, we report the influence of PLRG and freeze-dried allografts on healing of large femoral bone cysts. " 10/01/2012 - "A side-effect induced by the combination of a demineralized freeze-dried bone allograft and leucocyte and platelet-rich plasma during treatment for large bone cysts: a 4-year follow-up clinical study." 07/01/2014 - "We have started a prospective study for that treatment of unicameral bone cyst by using freeze dried radiation sterilized bone allograft impregnated with autogenous bone marrow in the department of Orthopaedics, Bangabandhu Sheikh Mujib Medical University (BSMMU) during May 1999 to April 2012. " 07/01/2014 - "Management of unicameral bone cyst by using freeze dried radiation sterilized bone allograft impregnate with autogenous bone marrow."
4.	Intramedullary Fracture Fixation 07/01/2006 - "Elastic stable intramedullary nailing is the best treatment of unicameral bone cysts of the long bones in children?: Prospective long-term follow-up study." 07/01/2007 - "The purpose of this study was to evaluate the outcome of flexible intramedullary nailing for unicameral bone cysts in terms of function and osseous consolidation. " 08/01/2010 - "During the period 2001 to 2007, flexible intramedullary nailing for the treatment of a unicameral bone cyst was performed in 18 children. " 07/01/2007 - "Twenty-two unicameral bone cysts in children's long bones were treated by flexible intramedullary nailing. " 01/01/2007 - "We performed demineralized bone matrix and iliac crest bone marrow injection combined with elastic intramedullary nailing for the treatment of simple bone cysts in long bones of 9 children with a mean age of 12.6 years (range, 4 to 15 years). "
5.	Bone Transplantation (Bone Grafting) 07/01/2013 - "Arthroscopic bone grafting of talar bone cyst using posterior ankle arthroscopy." 09/01/2005 - "Arthroscopic repair of rotator cuff tears associated with large bone cysts of the proximal humerus: compaction bone grafting technique." 08/01/2005 - "We report a case of a solitary bone cyst in the mandible of an elderly woman who presented with a bilateral radiolucent lesion that caused bony expansion, and which recurred 30 months after enucleation and bone grafting of the cavity." 12/01/2004 - "The author reports an adult man with a solitary bone cyst of the os calcis which was confirmed radiologically and histologically and successfully treated with curretage and bone grafting." 10/01/2000 - "We report on the outcome after autologous chondrocyte and spongiosal bone transplantation in a case of a massive intraosseous ganglion of the talus in a young patient. "