Blood Coagulation Disorders

Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.

Also Known As:

Networked: 100 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Liver Cirrhosis (Hepatic Cirrhosis)
2.	Afibrinogenemia (Fibrinogen Deficiency)
3.	Neoplasms (Cancer)
4.	Thrombosis (Thrombus)
5.	Hemorrhage

Experts

1.	Gespach, Christian: 2 articles (06/2007 - 12/2005)
2.	Gieseler, Frank: 2 articles (06/2007 - 12/2005)
3.	Zhang, Xiaojuan: 1 article (05/2015)
4.	Qin, Na: 1 article (05/2015)
5.	Guo, Shuxia: 1 article (05/2015)
6.	Chen, Xinghua: 1 article (05/2015)
7.	Arai, Yasuyuki: 1 article (03/2015)
8.	Hishizawa, Masakatsu: 1 article (03/2015)
9.	Yamazaki, Hiroyuki: 1 article (03/2015)
10.	Kitano, Toshiyuki: 1 article (03/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Blood Coagulation Disorders:

1.	VitaminsIBA 01/01/1990 - "It was stated that the aforementioned vitamin therapy significantly decreased postsurgical blood coagulation disorders (in those who were prepared for the operation beforehand it happened before adenomectomy), improved the clinical course and outcomes of the postsurgical period. " 01/01/1988 - "[Vitamins for the prevention of blood coagulation disorders during transvesical adenomectomies]."
2.	Annexin A2 (Annexin II)IBA 05/01/2015 - "We concluded that combination of ATO and DNR could promote APL and NB4 cell apoptosis effectively without aggravating blood coagulation disorders, which might improve coagulation function of APL by inhibiting coagulation and hyperfibrinolysis through reducing expression of TF and annexin II. This drug combination may be a safe and effective method in the treatment of APL of primary high white blood cells type. "
3.	Blood Coagulation Factors (Coagulation Factor)IBA 07/01/2002 - "There were no abnormal value changes of the coagulation factors between pre- and post-IVMRI, no clinical manifestations of blood coagulation disorders, and, histopathologically, no thermal damage in target vessels. " 07/01/1972 - "[Blood coagulation disorders caused by abnormal blood coagulation factors]." 07/01/2009 - "The purpose of this study was to evaluate the capacity of single coagulation factors to reverse gelatin-promoted whole-blood coagulation disorders in vitro. " 09/01/2003 - "The blood coagulation disorder, hemophilia A, is caused by deficiency of coagulation factor (F)VIII. Hemophilia A is now treated by infusions of pure FVIII, but the activity of FVIII is limited because it is unstable following activation by thrombin. " 01/01/1976 - "[Direct proteolysis of coagulation factors through granulocyte enzymes as a possible mechanism of blood coagulation disorders in acute leukemia and septicemia]."
4.	Prothrombin (Factor II)IBA 12/04/1958 - "[Use of the prothrombin test in the diagnosis of blood coagulation disorders]." 01/01/1987 - "A study of 93 patients with liver cirrhosis showed that the most important blood coagulation disorder in this pathology resulting in hypocoagulation, was not decreased synthesis and deficit of the prothrombin complex factors but disturbance of the final stage determined by afibrinogenemia. "
5.	Oral ContraceptivesIBA 02/15/1974 - "Epidemiological and clinical studies on the possible relationships between oral contraceptives and blood coagulation disorders are reviewed. " 07/01/1990 - "The most important pathophysiologic mechanisms are: a) modification of coronary risk factors: the pill produces an elevation of both serum cholesterol and trygliceride levels, increase of blood pressure and decompensation of diabetes mellitus; b) blood coagulation disorders: oral contraceptives increase platelet aggregation and fibrinogen blood levels, therefore they have a considerable thrombogenic capacity. "
6.	Silicon Dioxide (Sand)FDA LinkGeneric 01/01/2013 - "This study was designed specifically to investigate whether silica NPs with intravenous injection could lead to blood coagulation disorder and endothelium dysfunction in vivo. "
7.	GelatinIBA 07/01/2009 - "The purpose of this study was to evaluate the capacity of single coagulation factors to reverse gelatin-promoted whole-blood coagulation disorders in vitro. " 07/01/2009 - "Gelatin-induced whole-blood coagulation disorder in vitro is mainly dependent on the initial fibrinogen-fibrin interaction. "
8.	Fibrinogen (Factor I)FDA Link 12/01/2010 - "Fibrinogen assays are an important screening tool for blood coagulation disorders. " 09/15/1970 - "[Blood coagulation disorders caused by genetic variants of fibrinogen]." 07/30/1960 - "[On fibrinogen therapy of blood coagulation disorders in gestation]." 01/01/1973 - "[Fibrinogen B an an index for blood coagulation disorders in burns]." 07/01/1984 - "Indeed, blood coagulation disorders, such as altered fibrinogen and fibrin metabolism and increased incidence of vascular thrombosis, are common in patients with advanced malignant disease. "
9.	Vitamin KFDA Link 05/01/2010 - "[Blood coagulation disorder due to Vitamin K supplement: case report]." 03/11/2014 - "Understanding the mechanism of carboxylation and the role of GGCX in the vitamin K cycle is of biological interest in the development of therapeutics for blood coagulation disorders. " 12/01/1995 - "High concentrations are contraindicated in subjects with vitamin K-associated blood coagulation disorders, and the toxicity in normal subjects ingesting large amounts of vitamin E over long periods requires additional investigation. " 01/01/1953 - "[Effect of vitamin K on blood coagulation disorders in ethionine pancreatitis in rat]."
10.	ThrombinFDA Link 06/01/2007 - "Thus, we add new insights on the interconnections between blood coagulation disorders in cancer patients and thrombin activation in malignant effusions, including their functional interaction with PAR in metastatic cancer cells. " 12/15/2005 - "We also add new insights into the mechanisms linking the coagulation mediators thrombin and PAR-1 in the context of blood coagulation disorders and venous thrombosis often observed in cancer patients, as described in 1865 by Armand Trousseau." 09/01/2003 - "The blood coagulation disorder, hemophilia A, is caused by deficiency of coagulation factor (F)VIII. Hemophilia A is now treated by infusions of pure FVIII, but the activity of FVIII is limited because it is unstable following activation by thrombin. " 01/01/2006 - "thrombin, factor Xa, factor VIIa, trypsin, and in integrin receptor antagonists, used to treat many blood-coagulation disorders. "

Therapies and Procedures

1.	Blood Vessel Prosthesis 10/01/1984 - "Due to preclotting of the vascular prosthesis, autologous blood has shown good results provided that heparinization has not become necessary, or blood coagulation disorders are not present. "
2.	Extracorporeal Circulation 04/01/1977 - "[Study of blood coagulation disorders after operations with extracorporeal circulation in infants and children]." 07/01/1966 - "[Blood coagulation disorders in extracorporeal circulation and clinical study on preventive countermeasures]." 07/27/1987 - "[Blood coagulation disorders in extracorporeal circulation]." 10/01/1969 - "[Blood coagulation disorders and extracorporeal circulation]." 02/01/1969 - "[Postoperative blood coagulation disorders after heart surgery when using extracorporeal circulation]."
3.	Intravenous Injections 01/01/2013 - "This study was designed specifically to investigate whether silica NPs with intravenous injection could lead to blood coagulation disorder and endothelium dysfunction in vivo. "
4.	Tooth Extraction (Tooth Extractions) 01/01/1987 - "[Use of local-action hemostatic agents after tooth extraction in patients with blood coagulation disorders]." 01/01/1982 - "[Tooth extraction in children with blood coagulation disorders]." 02/09/1979 - "[New method of hemostasis following tooth extraction in blood coagulation disorders]." 09/01/1954 - "[Hemostasis after tooth extraction with special reference to blood coagulation disorders]."
5.	Blood Transfusion (Blood Transfusions) 01/01/1975 - "[Blood coagulation disorders in massive blood transfusion]." 05/27/1960 - "[The use of titriplex III for cross-matching for urgent blood transfusions and patients with blood coagulation disorders]." 01/01/1957 - "[Blood coagulation disorders caused by blood transfusions]." 02/23/1968 - "[Blood coagulation disorders and hemolysis after blood transfusion]."