Urinary Bladder Diseases (Bladder Diseases)

09/01/2001 - "Oral cimetidine gives effective symptom relief in painful bladder disease: a prospective, randomized, double-blind placebo-controlled trial."
02/01/2001 - "Oral cimetidine gives effective symptom relief in painful bladder disease: a prospective, randomized, double-blind placebo-controlled trial."
02/01/2001 - "To evaluate the efficacy of oral cimetidine as a treatment for painful bladder disease (PBD, variously described as a 'symptom complex' of suprapubic pain, frequency, dysuria and nocturia in the absence of overt urine infection) by assessing symptom relief and histological changes in the bladder wall tissue components, compared with placebo. "

12/29/2022 - "Intravesical hyaluronic acid (HA) supplementation, a therapeutic method to restore barrier function of bladder, avoid the stimulation of metabolic toxicants on bladder and reduce inflammatory response, has shown good results in acute or chronic bladder diseases. "
09/01/2021 - "[Effectiveness and safety of intravesical hyaluronic acid for symptom control in chronic bladder diseases.]"
10/01/2011 - "The role of sodium hyaluronate and sodium chondroitin sulphate in the management of bladder disease."

02/21/1986 - "Patients with neurological bladder disease were cured in a relatively high percentage of their Pseudomonas infection after three months treatment with norfloxacin. "

05/01/1992 - "In this case, only cyclophosphamide markedly improved the protein-losing enteropathy but did not influence the bladder disease."

10/01/2014 - "Empty LPs alone provide a therapeutic efficacy against acrolein-induced changes in urothelial cell viability and may be a promising local therapy for bladder diseases. "

06/01/2022 - "With the growing maturity of gene therapy, comprehensive studies are needed to provide a better understanding of the molecular mechanisms underpinning bladder diseases and help to identify novel gene therapeutic targets and biomarkers for treating bladder diseases. "
03/17/2023 - "The urine levels of biomarkers were compared between groups with bladder dysfunctions and controls and were combined to test the sensitivity in identifying total pathological bladder diseases and specific bladder diseases. "
01/01/2020 - "In this short review, we will discuss current efforts on identification of promising urinary biomarkers of bladder diseases and their roles in diagnosis and monitoring. "
01/01/2020 - "Biomarker discovery and beyond for diagnosis of bladder diseases."
04/01/2019 - "This study indicates that urothelial nuclear HIF-1α may be a biomarker of hypoxia and a common feature in end-stage bladder disease associated with high-pressure systems."

04/01/2016 - "Managing chronic bladder diseases with the administration of exogenous glycosaminoglycans: an update on the evidence."
07/01/2013 - "Furthermore, we will underline the role of glycosaminoglycans, focusing both on their pathophysiological role in the principal bladder diseases and on the therapeutic aspects from the clinical point of view. "
01/01/1994 - "The thin mucus or glycosaminoglycan layer of the bladder may be implicated in the pathogenesis of many bladder disease states. "
10/01/2011 - "There is strong evidence that different chronic inflammatory bladder diseases, such as recurrent urinary tract infection (UTI), chemical or radiation cystitis and painful bladder syndrome/interstitial cystitis (PBS/IC), can be pathophysiologically linked in the first step of the disease to the loss of the glycosaminoglycan (GAG) mucous layer independently of the original cause of the inflammatory process. "
02/01/1994 - "Polysaccharide therapy for bladder disease is a novel therapy based on the model of bladder mucus activity and the belief that mucus and exogenous glycosaminoglycans (GAG) have protective properties. "

10/01/2012 - "Findings of this study indicated results of miRNA expression assays can be used to distinguish between samples of grossly normal bladders and bladders of dogs with inflammatory bladder disease or TCC. "
12/27/2016 - "Expression profiling of 754 human microRNAs (TaqMan low density arrays) was performed on naturally voided urine samples from a cohort of 85 subjects of known bladder disease status (27 with active BCa). "
10/01/2012 - "To determine expression of microRNA (miRNA) in urinary bladder samples obtained from dogs with grossly normal urinary bladders, inflammatory bladder disease, or transitional cell carcinoma (TCC) and in cells of established canine TCC cell lines. "
10/01/2012 - "Expression of microRNAs in urinary bladder samples obtained from dogs with grossly normal bladders, inflammatory bladder disease, or transitional cell carcinoma."
01/01/2018 - "Urinary exosome preparations might contain specific miRNAs, relevant as biomarkers in renal and bladder diseases. "

01/01/2019 - "In this study, microarray analysis of bladder RNA revealed down-regulation of CAV1, CAV2, and CAV3 gene transcription in BSM from models of obstructive bladder disease in mice and humans. "
01/01/2021 - "With newer techniques, including single-cell RNA sequencing and reporter mice, an understanding is emerging of T cell roles in bladder diseases (bacterial infections, bladder cancer, chronic inflammation). "
01/01/2020 - "An unbiased profiling based on transcriptomics, proteomics, epigenetics, metabolomics approaches et al. found that expression at RNA, protein, and metabolite levels are linked with specific bladder diseases and outcomes. "

01/01/2020 - "This review highlights recent developments, findings on genetic knockout models, pharmacological data, reports on UBSM ion channel dysfunction in animal bladder disease models, and the very limited human studies currently available. "
02/16/2010 - "Some of these ion channels and receptors may be potential therapeutic targets for bladder diseases."
04/01/2016 - "Urothelial receptor and/or ion channel expression and the release of signalling molecules (such as ATP and nitric oxide) can be altered with bladder disease, neural injury, target organ inflammation, or psychogenic stress. "

12/01/2021 - "Intravesical drug delivery approaches for improved therapy of urinary bladder diseases."
01/01/2018 - "In this study, we present a targeted drug delivery system to improve intravesical therapy of bladder diseases. "
05/01/2008 - "Implementation of this methodology, which can potentially be automated for high throughput analysis, can accelerate the development of novel therapy for certain important aspects of bladder disease/dysfunction."
01/01/1992 - "The depletion of sensory nerves containing SP shortly after distension may explain the transient benefit obtained from distension therapy in patients with painful bladder disease. "
10/01/1966 - "[New therapy in female bladder diseases]."

01/01/2014 - "Adoption of forward-thinking approaches can achieve advancements in drug delivery systems targeted to future improvement in pharmacotherapy of bladder diseases. "
03/18/2020 - "O-1602 can improve DO, and may serve as a promising novel substance for the pharmacotherapy of bladder diseases."
05/01/1998 - "For prostatic disease only primary surgical therapy was associated with prolonged survival, while for bladder disease cisplatin chemotherapy was associated with a favorable prognosis. "

01/01/1989 - "[The efficacy of rigid and flexible endoscopes in the diagnosis of bladder diseases]."
11/01/2003 - "[Experience in the clinical application of semirigid mini-urethral endoscopes in the diagnosis and treatment of urinary bladder diseases]."
01/01/1989 - "A comparative assessment of the efficiency of rigid and flexible endoscopes used for the diagnosis of bladder diseases (cystitis, papilloma, carcinoma in a total of 250 patients) is reported. "

09/01/2016 - "Currently, the gold standard therapy of end-stage bladder disease refractory to conservative management is enterocystoplasty, a surgical enlargement of the bladder with intestinal tissue. "

11/01/2011 - "Because of its high affinity for the bladder, both systemically as reported in previous studies and after intravesical instillation as reported in the present study, R11 should be further tested in animal models as a delivery vector for agents used in treating bladder diseases."
05/31/2023 - "The intravesical instillation procedure is a proven method in modern urology for the treatment of bladder diseases. "
04/01/2022 - "[Intravesical instillations for inflammatory and sensory chronic bladder diseases: Literature review and guide to clinical practice]."
06/01/2016 - "In clinical settings, intravesical instillation of a drug bolus is often performed for the treatment of bladder diseases. "
01/01/2021 - "Intravesical instillation therapy is an alternative approach to oral medications for the treatment of severe bladder diseases, offering high drug concentrations at the site of action while minimising systemic side effects. "