Dicumarol (Dicoumarol)

01/01/2015 - "OGG1 knockdown, dicoumarol-treatment or NQO1- cancer cells were spared. "
03/01/2008 - "These findings are important to understand the mode of action of Hsp90 inhibitors, mechanisms of action of dicoumarol, and Securin overexpression in tumors."
12/09/2003 - "Although wild-type p53 and several p53 mutants were sensitive to dicoumarol-induced degradation, the most frequent "hot-spot" p53 mutants in human cancer, R175H, R248H, and R273H, were resistant to dicoumarol-induced degradation, but remained sensitive to Mdm2-ubiquitin-mediated degradation. "
07/15/2003 - "Mouse mammary tumor (EMT6) and Chinese hamster ovary (CHO) cells were treated with media containing either 10 or 1% fetal bovine serum and dicumarol (0-1000 microM) mimicking standard assay conditions. "
01/01/1985 - "These results suggest that a treatment regimen combining dicoumarol and MC might be a useful adjunct to radiation therapy for the eradication of the radioresistant hypoxic cells in solid tumors."

07/01/1960 - "Dihydrovitamin Kl biphosphate in bishydroxycoumarin induced hypoprothrombinemia."
09/01/1957 - "Relation between duration of hypoprothrombinemia with dicumarol and the level of the drug in the liver."
03/01/1952 - "[Effects of vitamine K 1 on hypoprothrombinemia caused by dicumarol and on the acceleration factors in the rabbit with liver damage and the hepatectomized cat]."
10/01/1951 - "Hypoprothrombinemia due to dicumarol in a malingerer: a case report."
06/01/1949 - "and synkayvite in reversing dicumarol hypoprothrombinemia."

06/01/1996 - "The author reviews the use of the main antithrombotic drugs (thrombolytics, dicumarol compounds, heparins and anti-platelet drugs) in the treatment and prophylaxis of the main nosographic syndromes of arterial and venous thrombosis. "
07/01/1975 - "The patients in this material had had 2-20 episodes of venous thrombosis, the most recent 5 years before the institution of treatment, in spite of dicoumarol treatment. "
02/15/1967 - "Postoperative anticoagulant prophylaxis of venous thrombosis with dicoumarol."
11/01/1951 - "[Complications in the treatment of venous thrombosis with dicumarol and its derivatives]."
04/01/1951 - "Venous thrombosis during pregnancy treated with dicoumarin."

01/01/1957 - "The effect of long term treatment with dicoumarol in myocardial infarction; a controlled clinical study."
01/01/1952 - "A study of the sedimentation rate in cases of myocardial infarction under dicumarol therapy."
10/01/1948 - "Acute myocardial infarction; detailed study of dicumarol therapy in 75 consecutive cases."
11/16/1973 - "[Letter: Dicoumarol therapy following myocardial infarct]."
03/01/1959 - "It is by this effect, apparently, that mortality has been reduced by 50 per cent among survivors of myocardial infarction who receive continuous dicoumarin therapy. "

09/01/2003 - "Thymic hemorrhage caused by dicumarol intoxication. "
06/01/1983 - "Thromboembolic complications occurred at an incidence of 1.17% per patient-year, and Dicumarol-induced hemorrhages occurred at an incidence of 2.11% per patient-year. "
07/17/1965 - "[Ovarian hemorrhage in the course of uncontrolled dicumarol therapy]."
07/01/1961 - "Adrenal hemorrhage associated with Dicumarol anticoagulation."
05/01/1959 - "[Massive bilateral renal hemorrhage in subjects under dicumarol treatment]."