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Biliverdine (Biliverdin)

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1,3,6,7-Tetramethyl-4,5-dicarboxyethyl-2,8-divinylbilenone. Biosynthesized from hemoglobin as a precursor of bilirubin. Occurs in the bile of AMPHIBIANS and of birds, but not in normal human bile or serum.

Also Known As:

Biliverdin; Biliverdin IX; Biliverdin IX alpha; IX alpha, Biliverdin; IX, Biliverdin; alpha, Biliverdin IX; Dehydrobilirubin; Ooecyan; Uteroverdine; 21H-Biline-8,12-dipropanoic acid, 3,18-diethenyl-1,19,22,24-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-

Networked: 123 relevant articles (12 outcomes, 12 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Otterbein, Leo E: 8 articles (01/2013 - 08/2003)
2.	Bach, Fritz H: 8 articles (01/2007 - 08/2003)
3.	Nakao, Atsunori: 7 articles (12/2012 - 08/2004)
4.	Yamashita, Kenichiro: 7 articles (01/2007 - 08/2003)
5.	Csizmadia, Eva: 6 articles (11/2011 - 04/2004)
6.	Ndisang, Joseph Fomusi: 4 articles (01/2014 - 03/2009)
7.	Inoguchi, Toyoshi: 4 articles (01/2013 - 11/2010)
8.	Billiar, Timothy R: 4 articles (12/2012 - 02/2005)
9.	Ollinger, Robert: 4 articles (01/2007 - 04/2004)
10.	Berberat, Pascal O: 3 articles (03/2013 - 04/2004)

Related Diseases

1.	Inflammation 12/01/2011 - "Oral biliverdin administration may lead to the production of active metabolite that protect from inflammation/complement activation." 05/01/2011 - "Biliverdin Rescues the HO-2 Null Mouse Phenotype of Unresolved Chronic Inflammation Following Corneal Epithelial Injury." 09/01/2008 - "Exacerbated corneal inflammation and neovascularization in the HO-2 null mice is ameliorated by biliverdin." 04/01/2006 - "The aim of this study was to investigate the protective effects of biliverdin against sepsis-induced inflammation and intestinal dysmotility. " 11/01/2007 - "Increasing serum levels of biliverdin and bilirubin was shown to be beneficial in settings of inflammation. "
2.	Reperfusion Injury 01/01/2013 - "Biliverdin protects against liver ischemia reperfusion injury in swine." 12/01/2012 - "Preservation solution supplemented with biliverdin prevents lung cold ischaemia/reperfusion injury." 08/01/2003 - "Biliverdin protects rat livers from ischemia/reperfusion injury." 06/01/2007 - "Exogenous biliverdin ameliorates ischemia-reperfusion injury in small-for-size rat liver grafts." 12/01/2004 - "Biliverdin therapy protects rat livers from ischemia and reperfusion injury."
3.	Lung Injury 01/01/2013 - "We also confirmed that biliverdin administration after hemorrhagic shock and resuscitation had protective effects on lung injury. " 01/01/2013 - "This study aimed to examine the effects of intravenous biliverdin administration on lung injury induced by hemorrhagic shock and resuscitation in rats. " 01/01/2013 - "Our findings suggest that biliverdin has a protective role, at least in part, against hemorrhagic shock and resuscitation-induced lung injury through anti-inflammatory and anti-oxidant mechanisms." 01/01/2013 - "Biliverdin administration prior to hemorrhagic shock and resuscitation significantly ameliorated these lung injuries as judged by histopathological improvement. " 06/01/2010 - "Biliverdin reversed the aggravation of Pa(O(2)) in recipients, reduced the grafts wet/dry ratio, decreased the severity of lung injury measured by histologic examination, reduced serum tumor necrosis factor-alpha and interleukin-8 levels and inhibited myeloperoxidase activity (MPO) in the grafts. "
4.	Sepsis (Septicemia) 04/01/2006 - "These findings demonstrate that biliverdin attenuates sepsis-induced morbidity to the intestine by selectively modulating the inflammatory cascade and its subsequent sequelae on intestinal muscularis function." 04/01/2006 - "Biliverdin treatment prevented the sepsis-induced suppression of gastrointestinal muscle contractility in vivo and in vitro and significantly decreased neutrophilic infiltration into the jejunal muscularis. " 04/01/2006 - "Biliverdin protects against polymicrobial sepsis by modulating inflammatory mediators." 04/01/2006 - "The aim of this study was to investigate the protective effects of biliverdin against sepsis-induced inflammation and intestinal dysmotility. " 01/01/2015 - "Exogenous bilirubin, or its precursor, biliverdin, is protective in rodent models of sepsis. "
5.	Brain Death (Brain Dead) 06/01/2010 - "In this study, we investigated the effects of biliverdin on lung grafts from brain dead (BD) rat donors. " 06/01/2010 - "Exogenous biliverdin improves the function of lung grafts from brain dead donors in rats." 04/01/2011 - "Protection against lung graft injury from brain-dead donors with carbon monoxide, biliverdin, or both."

Related Drugs and Biologics

1.	Carbon Monoxide
2.	Bilirubin
3.	Heme (Haem)
4.	Iron
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Interleukin-8 (Interleukin 8)
7.	Peroxidase (Myeloperoxidase)
8.	Dextrans (Dextran)
9.	sodium sulfate (sodium bisulfate)
10.	Heme Oxygenase-1

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Resuscitation
3.	Organ Transplantation
4.	Kidney Transplantation
5.	Transplantation (Transplant Recipients)