Biliary Dyskinesia

A motility disorder characterized by biliary COLIC, absence of GALLSTONES, and an abnormal GALLBLADDER ejection fraction. It is caused by gallbladder dyskinesia and/or SPHINCTER OF ODDI DYSFUNCTION.

Also Known As:

Networked: 164 relevant articles (19 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Gastroesophageal Reflux (GERD)
3.	Gallbladder Diseases (Gall Bladder Disease)
4.	Gastritis
5.	Acalculous Cholecystitis

Experts

1.	St Peter, Shawn D: 4 articles (05/2015 - 02/2008)
2.	Bielefeldt, Klaus: 4 articles (12/2014 - 07/2013)
3.	Petraccia, L: 2 articles (01/2014 - 01/2010)
4.	Fontana, M: 2 articles (01/2014 - 01/2010)
5.	Nocchi, S: 2 articles (01/2014 - 01/2010)
6.	Fraioli, A: 2 articles (01/2014 - 01/2010)
7.	Grassi, M: 2 articles (01/2014 - 01/2010)
8.	Azarow, Kenneth S: 2 articles (12/2013 - 05/2011)
9.	Brownie, Evan: 2 articles (12/2013 - 05/2011)
10.	Harmon, Carroll M: 2 articles (08/2013 - 06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Biliary Dyskinesia:

1.	CholesterolIBA 10/01/2013 - "Average body mass index (BMI) for patients with non-hemolytic (cholesterol) stones and biliary dyskinesia were significantly greater than the average BMI for patients with hemolytic stones (P < .0001). " 10/01/2013 - "In addition, the average BMI for children with non-hemolytic (cholesterol) stones was greater than the average BMI with biliary dyskinesia (P < .0001). " 10/01/2013 - "Although the number of cholecystectomies for hemolytic disease was relatively stable throughout our study, the number for biliary dyskinesia and non-hemolytic (cholesterol) cholelithiasis rose by 63% and 216%, respectively. " 01/01/1992 - "The proportion of cholestanol/cholesterol in hepatic and cystic bile was evaluated using capillary gas-chromatography in subjects with disturbances in the biliary system (biliary dyskinesia, chronic acalculous cholecystitis, chronic calculous cholecystitis). "
2.	SodiumIBA 05/01/1999 - "[The efficacy of treatment by drinking sodium-potassium chloride mineral water in patients with chronic acalculous cholecystitis and biliary dyskinesia]."
3.	Potassium ChlorideFDA LinkGeneric 05/01/1999 - "[The efficacy of treatment by drinking sodium-potassium chloride mineral water in patients with chronic acalculous cholecystitis and biliary dyskinesia]."
4.	Naloxone (Narcan)FDA LinkGeneric 05/01/1990 - "Daily administration of an opiate antagonist, naloxone (0.8 mg), significantly improved gallbladder dyskinesia and decreased the incidence of biliary sludge formation within 1 month of gastrectomy."
5.	lidofenin (HIDA)IBA 07/01/2015 - "HIDA Scan with Ejection Fraction Is over Utilized in the Management of Biliary Dyskinesia." 11/01/2011 - "Both 3D and 4D ultrasound techniques correlate well with HIDA scanning for calculating gallbladder EF in patients with suspected biliary dyskinesia." 10/01/2011 - "HIDA scan result is not a good prognostic indicator in children with suspected biliary dyskinesia. " 10/01/2011 - "We evaluated HIDA scan results as long-term prognostic indicators for biliary dyskinesia with or without intervention. " 09/01/1998 - "Patients presenting with biliary dyskinesia and an EF <50% on CCK-HIDA scan have 94% improvement or resolution of their symptoms after cholecystectorny. "
6.	Cholecystokinin (Pancreozymin)IBA 07/01/2003 - "The percentage of cholecystokinin-stimulated gallbladder emptying has been reputed to be the most sensitive diagnostic test for 'biliary dyskinesia', but abnormality of gallbladder emptying can be due to a smooth muscle defect of the gallbladder itself or heightened tone in the sphincter of Oddi. " 11/01/1997 - "Biliary dyskinesia: role of the sphincter of Oddi, gallbladder and cholecystokinin." 08/01/1965 - "[The use of cholecystokinin in the radiological diagnosis of biliary dyskinesias]." 04/01/2008 - "Most studies report use of cholecystokinin-cholescintigraphy (CCK-CS) with calculation of gallbladder ejection fraction in predicting symptom outcome after cholecystectomy in patients with suspected gallbladder dyskinesia. " 05/01/2004 - "Laparoscopic cholecystectomy for biliary dyskinesia: correlation of preoperative cholecystokinin cholescintigraphy results with postoperative outcome."
7.	SincalideFDA Link 11/01/2010 - "Sincalide infusion parameters: key information in a biliary dyskinesia clinical study." 10/01/1991 - "As the development of endoscopic manometry affords a modality to measure and record sphincter of Oddi pressures, the paradoxical responses noted to the intravenous administration of CCK during manometric evaluation supports the diagnostic value of Kinevac used as a provocative agent in the evaluation of biliary dyskinesia." 09/01/2014 - "The temporal association of EGR onset with sincalide infusion may identify patients with EGR mimicking chronic cholecystitis or biliary dyskinesia. " 03/01/2012 - "Of the cholecystectomies performed, approximately 30% are carried out for a diagnosis of gallbladder dyskinesia, for which diagnosis is based on a reduced gallbladder ejection fraction as determined by a sincalide (cholecystokinin) stimulated hepatobiliary iminodiacetic scan (CCK-HIDA). "
8.	Silicon Dioxide (Sand)FDA LinkGeneric 01/01/2010 - "After summarizing the general mechanism of action of mineral waters, the main indications of such waters in thermal treatment are examined including: biliary sand, biliary dyskinesia, functional dyspepsia, irritable colon, chronic primitive constipation. " 01/01/2014 - "We want to do a study on the effects of hydropinotherapy with a sulphate-bicarbonate-calcium-magnesium mineral water in patients suffering from pain and other symptoms caused by biliary dyskinesias, biliary sand (without gallstones), or following a cholecystectomy (post-cholecystectomy syndromes). "
9.	Nifedipine (Adalat)FDA LinkGeneric 10/01/1988 - "Effect of nifedipine on sphincter of Oddi motor activity: studies in healthy volunteers and patients with biliary dyskinesia." 03/01/2004 - "Decrease in contraction of gall bladder and normalization of tonic contraction of sphincter Ody was found in the patients with previously diagnosed hypertonic-hyperkinetic type of biliary dyskinesia after having been treated with Corinfar-Retard." 03/01/2004 - "Corinfar-Retard efficacy in patients with hypertonic-hyperkinetic type of biliary dyskinesia has been studied. "
10.	CalciumIBA 01/01/1955 - "[A particular biochemical situation found in certain cases of biliary dyskinesia; the relation between diffusible calcium and alacaline reserve; its importance and significance]." 01/01/2014 - "We want to do a study on the effects of hydropinotherapy with a sulphate-bicarbonate-calcium-magnesium mineral water in patients suffering from pain and other symptoms caused by biliary dyskinesias, biliary sand (without gallstones), or following a cholecystectomy (post-cholecystectomy syndromes). "

Therapies and Procedures

1.	Cholecystectomy 05/01/2008 - "Cholecystectomy is beneficial for most patients with biliary dyskinesia. " 01/01/2009 - "Some studies found that cholecystectomy produced symptomatic improvement in patients with gallbladder dyskinesia (diagnosed by low gallbladder ejection fraction) while others found no significant benefit. " 11/01/2006 - "The purpose of this study was to identify patient characteristics that may help to predict successful clinical outcomes in pediatric patients with biliary dyskinesia by comparing 2 groups of pediatric patients: those who underwent cholecystectomy and those who received no surgical intervention (control group). " 12/01/1999 - "Biliary dyskinesia patients who underwent cholecystectomy had significantly greater symptom improvement compared with nonsurgical patients. " 02/01/2008 - "Biliary dyskinesia is becoming more frequently diagnosed in children, and these patients respond favorably to cholecystectomy. "
2.	Laparoscopic Cholecystectomy 06/01/2008 - "Laparoscopic cholecystectomy is effective in providing both short-term and long-term improvement of symptoms in children with biliary dyskinesia." 02/01/2004 - "Therapeutic efficacy of laparoscopic cholecystectomy in the treatment of biliary dyskinesia." 11/01/2008 - "This study supports the use of laparoscopic cholecystectomy as a safe and effective treatment for biliary dyskinesia in the pediatric population. " 12/01/2010 - "Response to: Laparoscopic cholecystectomy is safe and effective for the treatment of biliary dyskinesia in the pediatric population." 11/01/2008 - "Laparoscopic cholecystectomy for treatment of biliary dyskinesia is safe and effective in the pediatric population."
3.	Vagotomy 11/01/1951 - "Vagotomy in the treatment of biliary dyskinesia." 07/01/1946 - "Pain and fever arising from the common bile duct and not associated with jaundice; report of 2 cases of choledocholithiasis treated by choledochostomy and 1 of post-cholecystectomy biliary dyskinesia relieved by vagotomy."
4.	Gastrectomy 03/01/1958 - "[Effects of duodenal & biliary dyskinesia on the sequelae of Pean type gastrectomy; dumping syndrome, bending the main biliary tract, duodeno-biliary polyspasms]." 05/01/1990 - "Daily administration of an opiate antagonist, naloxone (0.8 mg), significantly improved gallbladder dyskinesia and decreased the incidence of biliary sludge formation within 1 month of gastrectomy."
5.	Transcutaneous Electric Nerve Stimulation (TENS) 01/01/2003 - "Therefore, we think that TENS can be used effectively and safely as an optional therapeutic method in the treatment of biliary dyskinesia." 05/01/1991 - "Since the sphincter of Oddi (SO) receives a very dense VIP nerve supply, we evaluate the effect of TENS on SO motor activity and on VIP plasma concentrations in patients with biliary dyskinesia and in healthy volunteers. " 05/01/1991 - "The effect of transcutaneous nerve stimulation on sphincter of Oddi pressure in patients with biliary dyskinesia."