Bile Pigments (Bilin)

02/01/2016 - "Highly positive results for the γH2AX and S100P markers were noted in invasive carcinoma, BilIN, and IPNB, whereas positive results for γH2AX and negative results for S100P were noted in non-neoplastic biliary epithelium. "
07/01/2023 - "Neoplastic intraepithelial lesions without underlying infiltrating carcinoma in the surrounding mucosa of CCAs were considered to reflect high-grade BilIN. "
01/01/2021 - "However, the genetic and evolutionary relationships between BilIN and carcinoma remain unclear. "
02/01/2015 - "Their lesions were categorized as follows: invasive carcinoma (n = 16), IPNB (n = 8), BIlN-3 (n = 16), BilIN-1/2 (n = 40), nonneoplastic large bile duct (n = 55), and peribiliary gland (n = 55). "
05/01/2013 - "The overexpression of p53 was not identified in BilIN lesions and was less frequent in ICCs (18.2%) compared with ExCCs (38.1%) and gallbladder carcinomas (61.5%). "

11/01/2022 - "In contrast, BilIN-driven carcinogenesis was characterised by significant reduction of intraepithelial CD8+ T-lymphocytic infiltration from non-tumorous epithelium via BilIN (P = 0.008) to BTC (P = 0.004). "
11/01/2022 - "IPN and BilIN are immunologically distinct entities that undergo different immune-cell variations during biliary carcinogenesis. "
11/01/2022 - "Immune-cell dynamics during IPN- and BilIN-associated carcinogenesis were subsequently compared. "
02/01/2006 - "Carcinogenesis via BilIN was characterized by MUC2-/CK7+/CK20-with increasing MUC1 expression. "
11/01/2022 - "Intraepithelial CD8+ T-lymphocytic infiltration of biliary tissue decreased already at the IPN-precursor stage, whereas BilIN-associated carcinogenesis showed a slowly progressing reduction towards invasive carcinoma."

07/01/1996 - "Because the pathogenesis of fasting hyperbilirubinemia is not fully understood, the effect of fasting on disposition of bile pigments was investigated in rats. "
09/27/2006 - "Bilirubinemia and bile pigments were regularly assessed after cell transplantation. "
07/01/1965 - "NON-HEMOLYTIC HYPERBILIRUBINEMIA DUE TO A PRIMARY OVERPRODUCTION OF BILE PIGMENTS ("SHUNT HYPERBILIRUBINEMIA")."
10/01/1998 - "In the absence of liver function tests, gastrointestinal biopsy, or molecular techniques such as microsatellite DNA analysis, the presence of intraepidermal bile pigment might prove helpful in elucidating hyperbilirubinemia and allowing a pathologist to favor a diagnosis of GVHD over EM. "
04/01/1989 - "The significance of bile pigment deconjugation by beta-glucuronidase in canine hyperbilirubinemia."

10/01/2021 - "In this study, the high-grade BilIN of gallbladder was examined pathologically and compared with the intracholecystic papillary neoplasm (ICPN) of gallbladder. "
11/01/2007 - "In this study, the participation of cancer-related molecules in the progression of these two precursor lesions was examined, using 64 hepatolithiatic livers with BilIN lesions (45 livers) and IPNB lesions (19 livers) and 10 hepatolithiatic livers without neoplastic lesions as a control. "
09/18/2023 - "The presence of biliary neoplasia with extensive intraductal extension, in conjunction with ICC, should be considered as a variant of BilIN."
01/01/2023 - "In addition, low-grade biliary intraepithelial neoplasia (BilIN) was scattered throughout the lesion, and high-grade BilIN was partly observed in the peribiliary glands of the Ab. "
12/08/2022 - "However, among subclones in BilIN, a certain subclone commonly shrank in concurrent primary tumors. "

05/01/2016 - "The present study reports a case of BilIN in the common bile duct (CBD) in a 77-year-old man, who presented with upper abdominal malaise without jaundice. "
01/01/2003 - "At necropsy of the experimental animals, there were various degrees of generalized icterus and the livers were swollen and discolored by bile pigment. "
08/01/1985 - " Icterus and bile pigments in the urine and clinical evidence of liver damage are seen often. "
01/01/1983 - "A 1983 assessment of the value of bile pigment determinations in the diagnosis of jaundice."
10/01/1979 - "Plasma bile pigment conjugation modalities in icterus syndromes of various origin."