Bile Pigments (Bilin)

07/01/1996 - "Because the pathogenesis of fasting hyperbilirubinemia is not fully understood, the effect of fasting on disposition of bile pigments was investigated in rats. "
07/01/1965 - "NON-HEMOLYTIC HYPERBILIRUBINEMIA DUE TO A PRIMARY OVERPRODUCTION OF BILE PIGMENTS ("SHUNT HYPERBILIRUBINEMIA")."
09/27/2006 - "Bilirubinemia and bile pigments were regularly assessed after cell transplantation. "
10/01/1998 - "In the absence of liver function tests, gastrointestinal biopsy, or molecular techniques such as microsatellite DNA analysis, the presence of intraepidermal bile pigment might prove helpful in elucidating hyperbilirubinemia and allowing a pathologist to favor a diagnosis of GVHD over EM. "
04/01/1989 - "The significance of bile pigment deconjugation by beta-glucuronidase in canine hyperbilirubinemia."

01/01/2003 - "At necropsy of the experimental animals, there were various degrees of generalized icterus and the livers were swollen and discolored by bile pigment. "
08/01/1985 - " Icterus and bile pigments in the urine and clinical evidence of liver damage are seen often. "
01/01/1983 - "A 1983 assessment of the value of bile pigment determinations in the diagnosis of jaundice."
10/01/1979 - "Plasma bile pigment conjugation modalities in icterus syndromes of various origin."
01/01/1973 - "[Total serum bile pigments in jaundice of various genesis]."

11/01/2007 - "In this study, the participation of cancer-related molecules in the progression of these two precursor lesions was examined, using 64 hepatolithiatic livers with BilIN lesions (45 livers) and IPNB lesions (19 livers) and 10 hepatolithiatic livers without neoplastic lesions as a control. "
02/01/2015 - "Patients with cancer in the resection margin (R1) had a significantly shorter overall survival than those with resection margins free of tumor (R0) irrespective of the presence of BilIN (R0 vs R1; P < 0.001) or BilIN grade (BilIN-positive vs BilIN-negative, P = 0.6, and BilIN-1 + 2 vs BilIN-3, P = 0.58). "
07/15/2013 - "Two main premalignant lesions are known: biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the biliary tract (IPNB). "
11/01/2011 - "Despite well defined morphological features in BilIN, the molecular alterations seen during early tumor progression in the biliary tract are poorly understood."
04/01/2009 - "Although the key steps of cholangiocarcinogenesis remain unknown, it has been hypothesized that CC may develop through two key premalignant precursor lesions: biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile duct (IPNB). "

12/01/2011 - "This study consisted of 25 patients with PSC and bile duct neoplasia [16 with cholangiocarcinoma and nine with biliary intra-epithelial neoplasia (BilIN) equivalent to biliary dysplasia]. "
02/01/2015 - "In resection specimens of extrahepatic cholangiocarcinoma, BilIN was most frequent (N = 6 of 8; 75%). "
08/01/2014 - "Biliary intraepithelial neoplasia (BilIN) is considered to be a precursor or a noninvasive lesion of invasive cholangiocarcinoma. "
01/01/2014 - "Biliary intraepithelial neoplasia (BilIN) is a precursor lesion of hilar/perihilar and extrahepatic cholangiocarcinoma. "
05/01/2013 - "Immunohistochemical expression of p53 also was evaluated in BilIN lesions, ICCs, and extrahepatic cholangiocarcinomas (ExCCs). "

02/01/2015 - "Their lesions were categorized as follows: invasive carcinoma (n = 16), IPNB (n = 8), BIlN-3 (n = 16), BilIN-1/2 (n = 40), nonneoplastic large bile duct (n = 55), and peribiliary gland (n = 55). "
05/01/2013 - "The overexpression of p53 was not identified in BilIN lesions and was less frequent in ICCs (18.2%) compared with ExCCs (38.1%) and gallbladder carcinomas (61.5%). "
06/01/2010 - "Biliary tract carcinoma development and progression is associated with several gene alterations, but BilIN lesions have yet to be studied in detail by molecular techniques. "
10/31/2009 - "EZH2 expression showed a stepwise increase from BilIN to invasive carcinoma. "
04/01/2005 - "At first, 10 pathologists made a diagnosis (either of reactive/regenerative change, low-grade or high-grade biliary intraepithelial neoplasia (BilIN-1 and BilIN-2), or in situ carcinoma (BilIN-3)) based on their own criteria. "