Extrahepatic Cholestasis

05/01/2011 - "  In extrahepatic cholestasis, the elevation of LS which is probably attributed to the increased hydrostatic pressure in the liver, correlates positively with the accumulation of bilirubin but negatively with damage of hepatocytes indicated by ALT levels. "
04/01/1988 - "Eighteen patients with total extrahepatic cholestasis undergoing PTCD were classified into three groups, depending on the bilirubin decrease rate at two weeks after PTCD. "
05/01/1979 - " A disproportionate elevation of serum bilirubin vis-a-vis serum enzymatic activities separated potential IHC cases into intra- and extrahepatic cholestasis. "
01/01/1975 - "The role of the lymphatics in the regurgitation of bilirubin during acute and chronic extrahepatic cholestasis in the dog was studied after intravenous injection of 14C-bilirubin. "
09/01/1990 - "Patients with acute hepatitis during the first (n = 18) and third ('remission') week of the disease (n = 15), liver cirrhosis (n = 34), and extrahepatic cholestasis (n = 20) predominantly showed an increase in bilirubin conjugates.(ABSTRACT TRUNCATED AT 250 WORDS)"

01/01/2020 - "The aim of this study was to examine the Oat1 and Oat3 distribution in different cellular fractions under physiological conditions as well as the effects of extrahepatic cholestasis on membrane distribution of both proteins. "
02/01/2011 - "Decreased enterocyte proliferation and altered TJ protein expression might represent important mechanisms for intestinal barrier dysfunction and hyperpermeability in patients with extrahepatic cholestasis. "
05/01/2003 - "In conclusion, BDL-induced extrahepatic cholestasis caused posttranscriptional down-regulation of hepatocyte AQP8 protein expression. "
08/01/1974 - "Protein synthesis in neurons and glial cells by extrahepatic cholestasis in rats."
01/01/1974 - "Synthesis and turnover of liver proteins during extrahepatic cholestasis in the rat."

07/01/2009 - "There is increasing evidence that the integrity of antioxidant defenses is of vital importance in extrahepatic cholestasis, particularly with regard to the functioning of the liver's mitochondria. "
01/01/1995 - "These results suggest that there is an imbalance in the oxidative-antioxidant hepatic system in experimental extrahepatic cholestasis. "
08/01/2015 - "Antioxidant Effect of Sepia Ink Extract on Extrahepatic Cholestasis Induced by Bile Duct Ligation in Rats."
01/01/2004 - "A shift in free radical-antioxidant balance was proved in short-term extrahepatic cholestasis, antioxidant-type choleretic compounds can be investigated in this animal model. "
03/01/2002 - "These effects of silymarin suggest that it may be a useful agent for improving the antioxidant defensive system in extrahepatic cholestasis, but its choleretic property should be considered."

05/01/2012 - "This study aimed to investigate the mtDNA alterations that occurred during liver injury in patients with extrahepatic cholestasis. "
05/01/2012 - "Damage to mtDNA in liver injury of patients with extrahepatic cholestasis: the protective effects of mitochondrial transcription factor A."

03/01/2002 - "These effects of silymarin suggest that it may be a useful agent for improving the antioxidant defensive system in extrahepatic cholestasis, but its choleretic property should be considered."
03/01/2002 - "However, it is not known whether the antioxidant silymarin might have a beneficial effect in extrahepatic cholestasis in common bile duct ligated rats. "
10/01/2020 - "Silymarin loaded gold nanoparticles improved liver function, reduced cholestasis and oxidative stress parameters, with the increase of antioxidant support, and reduced inflammation and fibrosis in the liver of rats with extrahepatic cholestasis."

04/01/1981 - "The plasma clearance of pancuronium in patients with extrahepatic cholestasis was 16% lower than in a control group (1.47 +/- 0.11 ml min-1 kg-1 v. 1.76 +/- 0.21 ml min-1 kg-1), but the difference was not significant. "
04/01/1981 - "The increase of T 1/2 beta pancuronium in patients with extrahepatic cholestasis was mainly a consequence of the increase in the volume of distribution. "
04/01/1981 - "A significant increase in the elimination half-life T 1/2 beta of pancuronium (from 141 to 224 min) and a significant increase in the volume of the peripheral compartment (V2) was found in patients with extrahepatic cholestasis when compared with control patients. "
04/01/1981 - "Hepatic and renal disposition of pancuronium and gallamine in patients with extrahepatic cholestasis."
08/01/1980 - "Inhibition of hepatic uptake of Org 6368 and pancuronium in extrahepatic cholestasis might explain the significant alterations in the pharmacokinetics of the two steroid neuromuscular blocking drugs. "

01/01/1993 - "Minimal biliary excretion and enterohepatic recirculation of metoclopramide in patients with extrahepatic cholestasis."
01/01/1993 - "The biliary excretion and apparent oral clearance of metoclopramide (MCL) were determined after oral administration of 1 mg MCL/kg body weight to 10 patients suffering from extrahepatic cholestasis with nasobiliary tube for drainage of the common bile duct. "

03/01/1993 - "Biliary hyperpressure in rat extrahepatic cholestasis alters horseradish peroxidase biliary excretion."
03/01/1993 - "1. The authors investigated the effect of two extrahepatic cholestasis models (one by bile duct ligation and the other by choledocho-jugular fistula) on the hepatic clearance of horseradish peroxidase in male Sprague-Dawley rats divided into four groups. "

10/01/2020 - "Silymarin loaded gold nanoparticles improved liver function, reduced cholestasis and oxidative stress parameters, with the increase of antioxidant support, and reduced inflammation and fibrosis in the liver of rats with extrahepatic cholestasis."

01/01/1993 - "This was particularly evident in 7 subjects with extrahepatic cholestasis and an abnormal pattern of hepatic protein synthesis or impaired clearance of plasma protein C would appear to develop in such pathological conditions."

07/01/2022 - "The present study investigated its hepatoprotection in the rat model of extrahepatic cholestasis using Bile Duct Ligation (BDL). "
06/01/1998 - "In this study, the effects of extrahepatic cholestasis induced by bile duct ligation for 4 days on the uptake of [3H]MPP+ by rat freshly isolated hepatocytes and liver slices were determined. "
08/01/1993 - "The present study was carried out to investigate the biochemical and morphological changes in the liver after ligation of the hepatic artery (HA) in the presence and in the absence of extrahepatic cholestasis (EHC). "
01/01/1992 - "The present study was performed to correlate changes in hepatic morphology with hepatic artery ligation (HAL) in the presence of extrahepatic cholestasis (EHC). "
01/01/1990 - "The objective of the present study was to investigate hepatic alterations due to hepatic artery ligation in rats with chronic extrahepatic cholestasis. "

08/01/1989 - "Endoscopic sphincterotomy is a relatively safe and effective means of relieving extrahepatic cholestasis; however, its comparison with surgical techniques needs long-term, randomized studies."
01/01/1980 - "Endoscopic sphincterotomy is a relatively safe and effective method for treatment of extrahepatic cholestasis. "
04/01/1984 - "[Extrahepatic cholestasis: endoscopic papillotomy--indications]."
03/13/1982 - "Endoscopic sphincterotomy is a new procedure for the management of extrahepatic cholestasis. "
09/01/1980 - "Internal medicine-epitomes of progress: endoscopic sphincterotomy in the therapy of extrahepatic cholestasis."

01/01/1993 - "The biliary excretion and apparent oral clearance of metoclopramide (MCL) were determined after oral administration of 1 mg MCL/kg body weight to 10 patients suffering from extrahepatic cholestasis with nasobiliary tube for drainage of the common bile duct. "
10/01/2017 - "Using an extrahepatic cholestasis rat model by bile-duct ligation (BDL), daily oral administration of rosmarinic acid showed improvement effects on liver histology, serum biochemicals, ductular reaction, oxidative stress, inflammation, and fibrosis. "

02/01/1977 - "Duodenoscopic sphincterotomy is a relatively safe and effective means of relieving certain instances of extrahepatic cholestasis. "
05/01/1982 - "Duodenoscopic sphincterotomy is a safe method for relieving some common conditions of extrahepatic cholestasis. "
06/29/2020 - "We describe an uncommon presentation of disseminated Kaposi sarcoma causing extrahepatic cholestasis due to extrahepatic biliary tract involvement that resolved after sphincterotomy with biliary stenting. "

03/01/2005 - "ERCP procedure is quite an effective and safe method for diagnosis and treatment in patients with Billroth II anastomosis and extrahepatic cholestasis in spite of all difficulties."