Bicuculline

An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.

Also Known As:

6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one; Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-

Networked: 994 relevant articles (48 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - Bicuculline: 994
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        Bicuculline: 994
        bicuculline methiodide: 65
        bicuculline methobromide: 2
        bicuculline methochloride: 1
        bicuculline methoxide

Experts

1.	Leffler, Charles W: 10 articles (11/2017 - 05/2002)
2.	Parfenova, Helena: 10 articles (11/2017 - 05/2002)
3.	Quan, Zhe-Shan: 8 articles (08/2015 - 03/2009)
4.	Fornai, Francesco: 7 articles (03/2022 - 06/2003)
5.	Bar-Gad, Izhar: 7 articles (01/2021 - 08/2009)
6.	Wang, Shi-Ben: 6 articles (08/2015 - 07/2012)
7.	Deng, Xian-Qing: 6 articles (04/2014 - 07/2010)
8.	Slamberová, R: 6 articles (01/2011 - 05/2000)
9.	Ojewole, John A O: 6 articles (04/2008 - 12/2005)
10.	Belelovsky, Katya: 5 articles (01/2021 - 08/2009)

Related Diseases

1.	Seizures (Absence Seizure) 10/01/1982 - "At 14 h following administration, TMT provided little protection against bicuculline, INH or PTZ induced seizures. " 11/01/2017 - "The present study investigated whether sex differences contribute to cerebrovascular functions in healthy and epileptic newborn pigs.MethodsEpileptic seizures were induced in female and male newborn pigs by bicuculline. " 12/01/2000 - "In the present study, unilateral focal microinfusion of picomole quantities of bicuculline induced behavioural (focal and generalized) seizures in deep layers of all parts of the PC in two rat strains, Wistar and SD. " 03/01/2000 - "The results of this study indicate that 6 weeks of voluntary alcohol intake are sufficient for the development of physical dependence upon alcohol in the alcohol-preferring P rats as measured by susceptibility to bicuculline-induced seizures. " 08/01/1986 - "Combined 1H and 31P nuclear magnetic resonance spectroscopic studies of bicuculline-induced seizures in vivo."
2.	Hyperalgesia 04/01/2019 - "In contrast, bicuculline, a GABAA receptor antagonist, induced only punctate, but not dynamic, allodynia. " 08/01/2010 - "The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. " 05/26/2023 - "Intraperitoneal injection of bicuculline (0.5 and 1 mg/kg) decreased %MPE and AUC of %MPE, suggesting hyperalgesia. " 01/01/2023 - "All of the above effects of TGR5 or FXR agonists on mechanical allodynia, on the activation of glial cells, and on ERK pathway were abolished by intrathecal injection of the GABAA receptor antagonist bicuculline. " 11/18/1993 - "Prior spinal cord infusion of bicuculline, a gamma amino butyric acidA (GABAA) receptor antagonist, significantly reduces the severity of joint inflammation and prevents the development of heat hyperalgesia. "
3.	Bradycardia 04/01/1999 - "Intracerebroventricular administration of 0.3 and 0.5 nmol of bicuculline produces an increase in blood pressure and a slight bradycardia in non-epileptic Wistar rats. " 07/26/1996 - "Bicuculline induced cardiorespiratory changes which consisted mainly of an augmented respiratory rate, through shortening of expiratory duration, and of bradycardia. " 02/01/1992 - "Both the depressor and bradycardia responses of the nucleus fastigius and nucleus vestibularis superior were blocked by preinjection of bicuculline (a GABAergic receptor blocker) into the rostral ventrolateral medulla. " 01/01/1994 - "Microinfusion of bicuculline (10 nl/min/5 min, 1 ng/nl) into the AP produced significant hypotension (-27 +/- 4 mmHg) and bradycardia (-53 +/- 10 bpm). " 10/01/2003 - "The aortic baroreflex bradycardia was hardly affected by DMH or dPAG stimulation when bicuculline (5 pmol), a specific GABAA receptor antagonist, had previously been microinjected into the NTS. "
4.	Apnea 10/01/2007 - "Subsequent bicuculline administration reversed the effects of CGS and prevented the production of apnea compared with control at higher SLN stimulation levels. " 04/01/2001 - "Bicuculline also reduced SLN-induced apnea and duration of poststimulation apnea (P < 0.05). " 01/01/2006 - "Prior injection of the GABA(A)-receptor blocker bicuculline at 14 and 21 days eliminated the CGS-induced decrease in frequency and apnea. " 12/01/2002 - "Microinjection of the bicuculline produced apnea, whereas microinjection of CGP-35348 produced a decrease in Ti and an increase in expiratory duration. " 04/01/2001 - "We studied the effect of the GABA(A) receptor blocker bicuculline, given intravenously and intracisternally, on apnea induced by SLN stimulation. "
5.	Spinal Cord Injuries (Spinal Cord Injury) 04/01/2008 - "4. Bicuculline-induced effects on phrenic nerve activity were eliminated after C8 spinal cord transection and regular phrenic rhythm resumed indicating that bicuculline was not acting directly on phrenic motoneurons. " 10/28/2010 - "High spinal cord transection or infusion of the GABA(A) receptors antagonist, bicuculline, into the cisterna magna is effective in disrupting the reflex bradycardia. " 01/01/1986 - "The effects of the gamma-aminobutyric acid (GABA) antagonist bicuculline (BCC) on hindlimb motor performance was examined in mature spinal cats with spinal cord transections made either on the day of birth or at approximately two weeks postpartum and in chronic adult cats with spinal transections made in adulthood. " 03/01/2008 - "At 4 weeks after Th9-10 spinal cord transection awake cystometry and recordings of external urethral sphincter electromyogram were performed to examine the effect of intrathecal application of the gamma-aminobutyric acid A and B agonists muscimol and baclofen or the gamma-aminobutyric acid A and B antagonists bicuculline and saclofen (Tocris Cookson, Ellisville, Missouri), respectively, at the level of the L6-S1 spinal cord. "

Related Drugs and Biologics

1.	Picrotoxin
2.	Pentylenetetrazole (Metrazol)
3.	Strychnine
4.	N-Methylaspartate (NMDA)
5.	Muscimol
6.	Anticonvulsants (Antiepileptic Drugs)
7.	gamma-Aminobutyric Acid (GABA)
8.	Diazepam (Valium)
9.	Ethanol (Ethyl Alcohol)
10.	GABA-A Receptors (GABA(A) Receptor)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Sympathectomy (Sympathectomies)
3.	Injections
4.	Intravenous Administration
5.	Ligation