beta-Endorphin (Endorphin, beta)

A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.

Also Known As:

Networked: 1766 relevant articles (53 outcomes, 210 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stein, Christoph: 11 articles (01/2017 - 09/2001)
2.	Schäfer, Michael: 10 articles (01/2010 - 09/2001)
3.	Mousa, Shaaban A: 9 articles (01/2010 - 08/2003)
4.	Sarkar, Dipak K: 6 articles (01/2017 - 11/2006)
5.	Zalewska-Kaszubska, Jadwiga: 6 articles (02/2015 - 04/2005)
6.	Cheng, Juei-Tang: 5 articles (11/2020 - 01/2002)
7.	Dyr, Wanda: 5 articles (02/2015 - 11/2005)
8.	Hempelmann, Gunter: 5 articles (06/2009 - 02/2003)
9.	Matejec, Reginald: 5 articles (06/2009 - 02/2003)
10.	Gorska, Dorota: 4 articles (02/2015 - 09/2006)

Related Diseases

1.	Pain (Aches) 02/01/2003 - "Immediate influence of transcranial electrostimulation on pain and beta-endorphin blood levels: an active placebo-controlled study." 07/01/1993 - "The clinical usefulness of serum beta-endorphin as a measure of pain severity was not established under the experimental conditions of this study." 04/01/1992 - "Several studies have described changes in beta-endorphin-like immunoreactivity (beta-ELI) in the rat brain in response to pain and stress stimuli. " 03/01/1982 - "Such procedures may be useful for controlled and parametric studies of the mobilization of pituitary or brain pools of beta-endorphin under conditions involving merely anticipation of pain rather than the actual activation of ascending nervous pain pathways." 01/01/2021 - "Pain sensitivity and plasma beta-endorphin in adolescent non-suicidal self-injury."
2.	Neoplasms (Cancer) 01/01/1987 - "The purpose of the present study was to investigate the effects of TSN-5 on secretion of immunoreactive beta-endorphin (i beta-E) by mouse corticotropic tumor cells. " 07/16/2009 - "The concentration of beta-endorphin for EA treatment group increased by 51.457% in the blood and 12.6% in the brain respectively, compared to the tumor control group. " 07/16/2009 - "Furthermore, EA treatment effectively increased the concentration of beta-endorphin in blood and brain samples of the mice to a greater extent than that of the tumor control as well as the normal group. " 01/01/2009 - "The concentration of beta-endorphin for EA treatment group increased by 51.457% in blood 12.6% in brain respectively, compared with tumor control group. " 01/01/2009 - "Furthermore, EA treatment effectively increased the concentration of beta endorphin in blood and brain of mice more than tumor control as well as normal group. "
3.	Migraine Disorders (Migraine) 01/01/1990 - "In contrast, the patients of the waiting period (group MII) showed improvement in migraine after the waiting period but no changes in beta-endorphin. " 12/01/2003 - "Exercise was found to have beneficial effects on all migraine parameters (P < 0.0001) and to increase beta endorphin levels after the treadmill practice (P < 0.0001) and after the home exercise program except four patients not regularly attended to the program (P < 0.0001). " 09/01/1997 - "In addition, a significant increase in beta-endorphin levels was observed in the migraine patients who were treated in the true acupuncture group as compared with the values before treatment or with the values of the placebo acupuncture group. " 12/01/1992 - "Beta-endorphin in migraine." 08/01/1983 - "Circulating beta-endorphin levels at various stages of life: possible connections with migraine pathogenesis."
4.	Wounds and Injuries (Trauma) 05/01/1987 - "These studies establish a relationship between the alteration of circadian rhythmicity of plasma beta-endorphin-like immunoreactivity and the magnitude of trauma and injury." 05/01/1987 - "The purpose of the present study was to examine the long term effects of surgical trauma on plasma beta-endorphin dynamics. " 05/01/1995 - "Pain perception and serum beta-endorphin in trauma patients." 04/01/1994 - "The most obvious change was seen in beta-endorphin, suggesting that beta-endorphin plays a more important role in trauma. " 01/01/1993 - "The modifying influence of anaesthetic procedures on stress reaction linked to operating trauma was observed by measurement of plasma concentration of beta-endorphin. "
5.	Pituitary ACTH Hypersecretion 09/01/1988 - "In the present study we found that plasma and cerebrospinal fluid immunoreactive beta-endorphin (i beta-endorphin) levels were 60- and 120-fold higher than control values in horses with Cushing's disease. " 01/01/1980 - "In normal human plasma significant amounts of beta-endorphin were detected; increased levels were found in Addison's, Nelson's and Cushing's disease. " 04/01/1992 - "We have compared the results of these two techniques, together with those of a beta-endorphin assay, in 17 patients with Cushing's disease, 9 with the ectopic ACTH syndrome and 30 controls. " 09/01/1988 - "Equine Cushing's disease: differential regulation of beta-endorphin processing in tumors of the intermediate pituitary." 07/01/1986 - "Immunoreactive beta-endorphin was determined in the plasma of 37 elderly subjects (73 +/- 7 years of age), in 3 young or young adult subjects without adrenal disease, in 4 women with clinical adrenogenital syndrome, in 1 man with Cushing's disease. "

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	Hydrocortisone (Cortisol)
3.	Opioid Analgesics (Opioids)
4.	Naloxone (Narcan)
5.	beta-Lipotropin (Lipotropin)
6.	Neuropeptides
7.	Opioid Peptides (Opioid Peptide)
8.	Analgesics (Analgesic Drugs)
9.	Morphine (MS Contin)
10.	Narcotic Antagonists (Opioid Antagonists)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Transcutaneous Electric Nerve Stimulation (TENS)
4.	Resuscitation
5.	Lasers (Laser)