Berberine

An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.

Also Known As:

Networked: 778 relevant articles (97 outcomes, 228 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Jing-Gung: 12 articles (10/2009 - 11/2005)
2.	Feng, Yibin: 10 articles (12/2015 - 07/2009)
3.	Li, Ning: 10 articles (01/2015 - 06/2009)
4.	Yang, Jai-Sing: 9 articles (10/2009 - 01/2006)
5.	Lombardi, Paolo: 8 articles (10/2015 - 11/2012)
6.	Wang, Ning: 7 articles (12/2015 - 10/2009)
7.	Chen, Li: 7 articles (12/2015 - 10/2009)
8.	Hu, Tianhui: 7 articles (01/2015 - 01/2012)
9.	Jiang, Jian-Dong: 7 articles (01/2015 - 12/2008)
10.	Li, Yan: 6 articles (12/2015 - 01/2013)

Related Diseases

1.	Insulin Resistance 01/01/2010 - "Our study demonstrates berberine significantly improved fat-induced insulin resistance and diabetic phenotype in type 2 diabetic hamsters. " 01/01/2011 - "After 9-week berberine treatment, fat-induced insulin resistance and diabetic phenotype in type 2 diabetic hamsters were significantly improved. " 01/01/2013 - "We postulate that women with PCOS will have improved insulin resistance following berberine administration. " 12/01/2011 - "Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes." 02/14/2008 - "Insulin resistance induced by FFAs in 3T3-L1 adipocytes can be improved by berberine. "
2.	Neoplasms (Cancer) 02/15/2014 - "These studies demonstrate that the SNEDDS of berberine is a promising strategy for improving its therapeutic efficacy and have potential application in the treatment of chronic inflammatory conditions and cancer." 01/01/2011 - "Meanwhile, the known mechanisms of berberine hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, along with improvement in patient quality of life, could also provide new insights into cancer cell metabolism and nanoparticulate delivery preparation." 12/24/2015 - "Unspecified cancer type and staging, fluctuated dose information and variants of targets across studies of berberine/ Coptidis Rhizoma impede their clinical use for cancer treatment. " 12/24/2015 - "Studies were focused on the pharmacological actions of Coptidis Rhizoma and berberine in cancer progression. " 11/03/2015 - "In the current study, we identified a small molecule, Ber8, from a series of 9-substituted berberine derivatives and found that it could induce acute cell growth arrest and senescence in cancer cells, but not in normal fibroblasts. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2008 - "To determine whether this compound is useful in the treatment of breast cancer, we analyzed the impact of berberine on the human breast cancer cell lines MCF-7 and MDA-MB-231 cells. " 11/01/2013 - "In this study, we investigated the efficacy of some new synthetic derivatives of berberine, a phytochemical isolated from Barberry and other plants, to induce growth arrest of HER-2/neu overexpressing SK-BR-3 breast cancer cells. " 04/01/2015 - "Therefore, berberine showed to be a good candidate for further studies as a new anticancer drug in the treatment of human breast cancer." 02/01/2015 - "To explore the precise mechanism, berberine-induced oxidative stress and mitochondrial-related apoptotic pathway in human breast cancer cells were investigated in this study. " 11/01/2012 - "The present study aimed to investigate the effects of the concomitant administration of berberine and radiation on breast cancer. "
4.	Inflammation 12/05/2013 - "Berberine (BBR) treatment significantly inhibited renal inflammation and thus improved renal damage in diabetes. " 01/01/2015 - "This study aimed to investigate whether berberine could prevent vascular remodeling and inflammation in the MS condition. " 06/01/2014 - "This study is designed to investigate the effects of berberine on adhesion and inflammation after abdominal surgeries and the underlying molecular mechanisms. " 02/01/2014 - "In the present study, we investigated the relationship between AMPK and Nrf2 signal pathways in lipopolysaccharide (LPS)-triggered inflammatory system, in which berberine (BBR), a known AMPK activator, was used for inflammation suppression. " 12/01/2013 - "The results of the current study showed the nephroprotective activity of berberine against CP-induced renal injury, which could be attributed to the inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis."
5.	Colitis 06/01/2012 - "The results suggest that the protective effects of berberine against the DSS-induced colitis may be associated with the regulation of cytokine production." 10/01/2015 - "Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation." 12/01/2010 - "Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation." 10/01/2015 - "Berberine (BBR), a compound long used in traditional Chinese medicines, has been reported to have therapeutic effects in treating experimental colitis. " 07/01/2015 - "Berberine was administered through gavage to C57BL/6 mice with established CDI-induced intestinal injury and colitis. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Blood Glucose (Blood Sugar)
3.	Insulin (Novolin)
4.	Triglycerides (Triacylglycerol)
5.	Antioxidants
6.	isoquinoline
7.	Cisplatin (Platino)
8.	palmatine
9.	Metformin (Glucophage)
10.	Lipids

Related Therapies and Procedures

1.	Radiotherapy
2.	Heterologous Transplantation (Xenotransplantation)
3.	Aftercare (After-Treatment)
4.	Immunomodulation
5.	Complementary Therapies (Alternative Medicine)