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Benzydamine (Tantum)

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A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.

Also Known As:

Tantum; 3M Brand of Benzydamine Hydrochloride; Benzidamine; Benzydamine Hydrochloride; Benzydamine Monohydrochloride; CSC Brand of Benzydamine Hydrochloride; Chefaro Brand of Benzydamine Hydrochloride; Difflam; Eipico Brand of Benzydamine Hydrochloride; Farma Lepori Brand of Benzydamine Hydrochloride; Grossmann Brand of Benzydamine Hydrochloride; Innotech Brand of Benzydamine Hydrochloride; Lonol; Novo-Benzydamine; Novopharm Brand of Benzydamine Hydrochloride; Opalgyne; PMS-Benzydamine; Pharmascience Brand of Benzydamine Hydrochloride; Promeco Brand of Benzydamine Hydrochloride; Ratiopharm Brand of Benzydamine Hydrochloride; Rosalgin; Sun Brand of Benzydamine Hydrochloride; Sun-Benz; Tantum Topico; United Drug Brand of Benzydamine Hydrochloride; Vantal Brand of Benzydamine Hydrochloride; ratio-Benzydamine; Hydrochloride, Benzydamine; Monohydrochloride, Benzydamine; Novo Benzydamine; PMS Benzydamine; Sun Benz; ratio Benzydamine; Benzindamine; 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-

Networked: 178 relevant articles (38 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azoles: 413
    - Pyrazoles: 26
      - Indazoles: 7
        Benzydamine: 178
        benzydamine N-oxide
- 2-Ring Heterocyclic Compounds
  - Indazoles: 7
    - Benzydamine: 178
      - benzydamine N-oxide

Experts

1.	Kanaev, S V: 3 articles (01/2010 - 01/2003)
2.	Baranov, S B: 3 articles (01/2010 - 01/2003)
3.	Cheng, K K F: 3 articles (12/2004 - 12/2003)
4.	Elad, Sharon: 2 articles (11/2013 - 03/2011)
5.	Epstein, J B: 2 articles (09/2011 - 08/2001)
6.	Epstein, Joel B: 2 articles (03/2011 - 12/2003)
7.	Hung, Nan-Kai: 2 articles (10/2010 - 10/2010)
8.	Wu, Ching-Tang: 2 articles (10/2010 - 10/2010)
9.	Cherng, Chen-Hwan: 2 articles (10/2010 - 10/2010)
10.	Lee, Meei-Shyuan: 2 articles (10/2010 - 10/2010)

Related Diseases

1.	Pain (Aches) 01/01/1986 - "Thermograms were taken on day 0 and day 6. The results showed significant relief of spontaneous pain, significant reduction in tenderness on pressure and in swelling on days 2, 4 and 6 of the trial, and a significant reduction in functional impairment on days 4 and 6, in the patients who had received the 3% benzydamine cream." 01/01/1985 - "The efficacy of benzydamine is mainly manifested against phenomena such as pain and oedema which depend on local mechanisms in the inflammatory focus. " 10/01/1988 - "A clinical study with Opalgyne was undertaken in order to relieve the pain due to the treatment of vulvo-vaginal condylomas. " 01/01/1985 - "The results of the study showed that benzydamine possessed a significant analgesic activity as evidenced by relief of mouth and throat pain induced by radiation therapy. " 09/01/2004 - "Topical benzydamine cream and the relief of pressure pain."
2.	Stomatitis 01/01/2009 - "This study was a prospective, randomized clinical trial carried out to explore the efficacy of payayor in the prevention and relief of radiation-induced oral mucositis compared with benzydamine. " 03/01/2015 - "Efficacy of benzydamine oral rinse in prevention and management of radiation-induced oral mucositis: A double-blind placebo-controlled randomized clinical trial." 03/01/2015 - "Several studies have demonstrated positive effects of benzydamine oral rinse in prevention of radiation-induced oral mucositis. " 06/01/1989 - "Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse." 03/01/2015 - "Benzydamine oral rinse can be considered as an effective, safe and well-tolerated medication for prevention of radiation-induced oral mucositis and alleviating its symptoms."
3.	Mucositis 09/01/2012 - "A significant reduction in mucositis in honey-received patients compared with 0.15% benzydamine hydrochloride, 0.9% normal saline applied patients occurred. " 03/01/2009 - "We evaluated the efficacy of benzydamine oral rinse for prevention of radiation-induced mucositis. " 01/01/1985 - "A double-blind, randomized clinical study was undertaken to determine the analgesic and antiinflammatory effectiveness of benzydamine in patients with radiation-induced mucositis of the oropharynx. " 01/01/2015 - "Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis and showed no side effects. " 01/01/2015 - "The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days). "
4.	Vaginitis 11/01/1992 - "Therefore benzydamine was considered highly effective in 92% of vaginitis caused by Gardnerella vaginalis." 01/01/1980 - "Vaginal smears, performed a few days after the end of the treatment period, and the improvement in symptoms and sings, demonstrated the curative action of benzydamine in mild non-specific vaginitis as well as its symptomatic effect and potentiation of specific therapy in moderate and severe bacterial, monilial and trichomonal vaginitis." 11/01/1992 - "The present clinical trial has been carried out in order to evaluate the efficacy of benzydamine in treatment of vaginitis caused by Gardnerella vaginalis. " 01/01/1987 - "The authors report the preliminary results of their investigation of the efficacy of benzydamine in the treatment of the so-called non-specific vaginitis. " 01/01/1987 - "The antiinflammatory effect of benzydamine compared with a placebo in a randomized study is reported in the treatment of trichomonas- and candida-induced vaginitis. "
5.	Pharyngitis (Sore Throat) 01/01/1985 - "The findings indicate that benzydamine hydrochloride is safe and effective therapy for the signs and symptoms of sore throat." 01/01/1985 - "Double-blind study of benzydamine hydrochloride, a new treatment for sore throat." 10/01/2013 - "Efficacy of benzydamine hydrochloride dripping at endotracheal tube cuff for prevention of postoperative sore throat." 03/01/2014 - "Benzydamine hydrochloride on postoperative sore throat: a meta-analysis of randomized controlled trials." 10/01/2010 - "The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat."

Related Drugs and Biologics

1.	Benzydamine (Tantum)
2.	Chlorhexidine
3.	Aspirin (Acetylsalicylic Acid)
4.	Mouthwashes
5.	Povidone-Iodine (Betadine)
6.	chlorhexidine gluconate (Dyna-Hex)
7.	Ibuprofen (Motrin)
8.	Piroxicam (Feldene)
9.	Indomethacin (Indometacin)
10.	Suppositories (Vaginal Suppositories)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Tonsillectomy
5.	Palliative Care (Palliative Medicine)