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Benztropine (Benzatropine)

Subscribe to New Research on Benztropine

A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine.

Also Known As:

Benzatropine; Cogentin; Apo-Benztropine; Apotex Brand of Benzatropine Mesilate; Astra Brand of Benzatropine Mesilate; Bensylate; Benzatropine Mesylate; Benzatropine Methanesulfonate; Benzatropine Methanesulfonate, Hydrobromide; Benzatropine Methanesulfonate, Hydrobromide, (endo)-Isomer; Benzatropine Methanesulfonate, Hydrochloride, (endo)-Isomer; Benztropine Mesylate; Cogentinol; ICN Brand of Benzatropine Mesilate; N-Methylbenztropine; PMS-Benztropine; Pharmascience Brand of Benzatropine Mesilate; Apo Benztropine; ApoBenztropine; Hydrobromide Benzatropine Methanesulfonate; Mesylate, Benzatropine; Mesylate, Benztropine; Methanesulfonate, Benzatropine; Methanesulfonate, Hydrobromide Benzatropine; N Methylbenztropine; PMS Benztropine; PMSBenztropine; 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-

Networked: 156 relevant articles (15 outcomes, 17 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Eddington, Natalie D: 4 articles (12/2008 - 07/2006)
2.	Newman, Amy H: 4 articles (12/2008 - 07/2006)
3.	Ferragud, Antonio: 3 articles (06/2011 - 11/2009)
4.	Canales, Juan J: 3 articles (06/2011 - 11/2009)
5.	Othman, Ahmed A: 3 articles (12/2008 - 01/2007)
6.	Newman, Amy Hauck: 3 articles (01/2008 - 09/2002)
7.	Katz, Jonathan L: 3 articles (10/2007 - 07/2006)
8.	Hernández-Rabaza, Vicente: 2 articles (12/2009 - 11/2009)
9.	Merino, Virginia: 2 articles (12/2009 - 11/2009)
10.	Velázquez-Sánchez, Clara: 2 articles (12/2009 - 11/2009)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 06/01/2001 - "Using quantitative autoradiography, the authors analyzed the binding of the M(1)/M(4) receptor selective antagonist [(3)H]pirenzepine in prefrontal cortex (Brodmann's areas 8, 9, 10, and 46) from schizophrenia patients who had (N=6) or had not (N=11) been treated with the anticholinergic agent benztropine mesylate and from normal comparison subjects (N=20). " 06/01/1987 - "All patients had been diagnosed as having schizophrenia or schizoaffective disorder, all were receiving stable doses of fluphenazine decanoate, and all had received benztropine mesylate in an attempt to rule out neuroleptic-induced akinesia. " 07/01/1998 - "The purpose of this study was to compare the efficacy of olanzapine with that of chlorpromazine plus benztropine in patients with treatment-resistant schizophrenia. " 10/01/1994 - "Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. " 08/21/1975 - "A comparative study of haloperidol and chlorpromazine in terms of clinical effects and therapeutic reversal with benztropine in schizophrenia. "
2.	Sialorrhea 06/01/1989 - "This study assessed the efficacy of synthetic anticholinergic benztropine and incidence of side-effects in 20 developmentally-disabled patients with severe drooling. " 06/01/1989 - "Efficacy of benztropine therapy for drooling." 09/01/2011 - "During titration to a dose of 300 mg daily and despite taking concomitant oral benztropine 1 mg twice daily, the patient began to experience mild sialorrhea. " 06/01/1989 - "A significant decrease in drooling during the benztropine condition relative to placebo was demonstrated and conservative response rates (calculated by deleting placebo responders), ranged up to 65 to 70 per cent. " 07/01/2011 - "Adverse effects included hypersalivation and tremor, which were treated with benztropine and propranolol. "
3.	Psychomotor Agitation (Akathisia) 10/01/1982 - "The first consisted of acute dystonic, dyskinetic, parkinsonian, and akathisia-like reactions, which worsened after each injection, were not exacerbated by drug withdrawal, and could be abolished or prevented with benztropine. " 01/01/1993 - "Both propranolol and benztropine significantly improved akathisia by Day 3-5 of treatment. " 05/01/2000 - "This study assessed changes in akathisia and psychopathology in 19 patients after separate one-day treatments with intramuscular benztropine and oral propranolol. " 05/01/2000 - "Changes in psychopathology correlated significantly with changes in subjective measures of akathisia after benztropine and with subjective and objective measures of akathisia after propranolol. " 05/01/2000 - "Benztropine and propranolol led to clinically meaningful and statistically significant decrements in ratings of subjective and objective measures of akathisia and in psychopathology scores. "
4.	Tremor (Tremors) 04/01/1997 - "We performed a double-blind crossover trial with a 2-week washout, comparing low-dose clozapine to benztropine for the treatment of tremor in PD. " 04/01/1997 - "Benztropine and clozapine were equally effective in improving tremor and the motor score of the United Parkinson's Disease Rating Scale at mean doses of 3.0 and 39 mg/day, respectively. " 07/01/2011 - "Adverse effects included hypersalivation and tremor, which were treated with benztropine and propranolol. " 09/05/2008 - "Analyses of the age, chlorpromazine equivalents, benztropine equivalents, the number of patients using anticholinergic medication, and the utilization patterns of the antipsychotic medication did not show statistically significant differences between patients with and without AIP, rigidity, bradykinesia, rest-tremor. " 04/01/1997 - "Benztropine versus clozapine for the treatment of tremor in Parkinson's disease."
5.	Parkinson Disease (Parkinson's Disease) 01/01/1981 - "The effects of chronic administration of the anticholinergic agent, benztropine mesylate (CogentinTM), on specific verbal memory were investigated as part of a placebo-controlled randomized double-blind crossover study to determine the clinical efficiency of CogentinTM as an adjuvant therapy with SinemetTM in Parkinson's disease. " 04/01/2001 - "Benztropine is an anticholinergic agent used in the treatment of Parkinson's disease and drug induced extrapyramidal disorders. " 06/05/2008 - "Benztropine (BZ) is a potent muscarinic receptor antagonist that has been used for the treatment of Parkinson disease. " 04/01/1997 - "Benztropine and clozapine were equally effective in improving tremor and the motor score of the United Parkinson's Disease Rating Scale at mean doses of 3.0 and 39 mg/day, respectively. " 04/01/1997 - "Benztropine versus clozapine for the treatment of tremor in Parkinson's disease."

Related Drugs and Biologics

1.	Chlorpromazine (Thorazine)
2.	Trihexyphenidyl (Artane)
3.	Cocaine (Cocaine HCl)
4.	olanzapine (Zyprexa)
5.	Scopolamine (Hyoscine)
6.	Propranolol (Inderal)
7.	Clozapine (Clozaril)
8.	fluphenazine depot (modecate)
9.	Lorazepam (Ativan)
10.	Biperiden (Akineton)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Anesthesia
3.	Therapeutics
4.	Intramuscular Injections
5.	Psychology Biofeedback (Biofeedback)