Benzoylarginine Nitroanilide

A chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., papain and trypsin, by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product.

Also Known As:

Benzoylarginine Nitroanilide Monohydrochloride; Benzoylarginine Nitroanilide, (R)-Isomer; Benzoylarginine Nitroanilide, (S)-Isomer; Benzoylarginine Nitroanilide, Monosodium Salt, Monohydrochloride; N-Benzoylarginine-4-nitroanilide; N-Benzoylarginyl-4-nitroanilide; Monohydrochloride, Benzoylarginine Nitroanilide; N Benzoylarginine 4 nitroanilide; N Benzoylarginyl 4 nitroanilide; N alpha Benzoyl DL arginine 4 nitroanilide; Nitroanilide, Benzoylarginine; BAPNA; N-alpha-Benzoyl-DL-arginine-4-nitroanilide; Benzamide, N-(4-((aminoiminomethyl)amino)-1-(((4-nitrophenyl)amino)carbonyl)butyl)-, (+-)-

Networked: 18 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lisowska-Myjak, Barbara: 3 articles (01/2007 - 01/2003)
2.	Pachecka, Jan: 3 articles (01/2007 - 01/2003)
3.	Kumar, Rajesh: 1 article (05/2021)
4.	Kumathalli, Kanteshwari: 1 article (05/2021)
5.	Rahalkar, Apurva: 1 article (05/2021)
6.	Bendre, Ameya D: 1 article (07/2019)
7.	Ramasamy, Sureshkumar: 1 article (07/2019)
8.	Shanmugam, Dhanasekaran: 1 article (07/2019)
9.	Suresh, C G: 1 article (07/2019)
10.	Balejo, Rodrigo D P: 1 article (12/2011)

Related Diseases

1.	Tics (Tic) 12/01/2006 - "The concentrations of AAT, alpha-2-M and AT-III were determined by the radial immunodiffusion method on NOR-Partigen plates (Dade-Behring), while TIC was determined by the method using BAPNA as substrate. " 01/01/2007 - "TIC was assessed using BAPNA (N-benzoyl-DL-arginine-p-nitroanilide). " 04/01/1983 - "In separate studies, functional protease inhibitor activity in scleroderma sera was determined by the capacity of serum to inhibit BAPNA hydrolysis by trypsin (TIC). " 01/10/2003 - "Trypsin inhibitory capacity (TIC) in the serum was determined with N-benzoyl-DL-arginine-p-nitroaniline (BAPNA, Sigma) as substrate. " 08/01/2006 - "Trypsin activity was measured using L-TAPA (N-alpha-tosyl-l-arginine-p-nitroanilide) as substrate, trypsin inhibitory capacity (TIC) with N-alpha-benzoyl-dl-arginine-p-nitroanilide (BAPNA) as substrate, and protein concentration by the method of Lowry et al. Meconium and feces of healthy newborns demonstrated a decrease in TIC during the first two days of life and an increase in trypsin activity over the first three successive days of life. "
2.	Hemorrhage 05/01/2021 - "Clinical parameters Probing Pocket Depth, Clinical Attachment Level, Plaque Index, Gingival Index, and modified Sulcus Bleeding Index were recorded and subgingival plaque sample collected for N-benzoyl-L-arginine-p-nitroanilide (BAPNA) assay on baseline followed by LDD with extracts in the assigned group. " 01/01/2011 - "Plaque index (PI), gingival index (GI), sulcus bleeding index (SBI), probing pocket depth (PPD), relative attachment loss (RAL), microbiological study of collected plaque sample for trypsin-like activity of "red complex" by BAPNA assay were the parameters recorded on day 0, 30 days and 45 days. "
3.	Inflammation (Inflammations) 09/01/2005 - "This study demonstrated that supragingival plaque control provides a reduction in gingival inflammation and alterations in the subgingival microflora detected by the BAPNA test."
4.	Gingivitis 12/01/2002 - "The objective of this study was to evaluate the effect of three commercial anti-plaque dentifrices containing 0.3% triclosan + 2% pvm/ma (Colgate Total), 0.3% triclosan + 0.75% Zn (Signal Global) and 0.3% triclosan + 5% PPi (Crest Complete) in comparison with an experimental dentifrice (0.3% triclosan + 2% pvm/ma + 0.75% Zn + 4% PPi) and a control dentifrice without anti-plaque agents on trypsin-like activity in dental plaque (detected by the hydrolysis of [Na-Benzoyl-DL-Anginine p-Nitroanilide (BAPNA)] and volatile sulphur compounds (VSCs) in mouth air during experimental gingivitis development. "
5.	Dental Plaque 12/01/2002 - "After each period, VSCs in mouth air and BAPNA hydrolysis by dental plaque accumulated in the experimental quadrant were determined. " 12/01/2002 - "The objective of this study was to evaluate the effect of three commercial anti-plaque dentifrices containing 0.3% triclosan + 2% pvm/ma (Colgate Total), 0.3% triclosan + 0.75% Zn (Signal Global) and 0.3% triclosan + 5% PPi (Crest Complete) in comparison with an experimental dentifrice (0.3% triclosan + 2% pvm/ma + 0.75% Zn + 4% PPi) and a control dentifrice without anti-plaque agents on trypsin-like activity in dental plaque (detected by the hydrolysis of [Na-Benzoyl-DL-Anginine p-Nitroanilide (BAPNA)] and volatile sulphur compounds (VSCs) in mouth air during experimental gingivitis development. "

Related Drugs and Biologics

1.	Trypsin
2.	Tuberculin (PPD)
3.	Triclosan (pHisoHex)
4.	Protease Inhibitors (Protease Inhibitor)
5.	Nitroglycerin (Dynamite)
6.	Dentifrices (Dentifrice)
7.	hydrated silica gel-based toothpaste
8.	Crest Complete
9.	Arginine (L-Arginine)
10.	Enzymes