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Benzocaine (Americaine)

A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

Also Known As:

Americaine; Hurricaine; 4-Aminobenzoic Acid Ethyl Ester; Anaesthesin; Anesthesin; Bensokain; Benzocaine Acetate; Benzocaine Formate; Benzocaine Hydrobromide; Benzocaine Hydrochloride; Benzocaine Methanesulfonate; Ethoform; 4 Aminobenzoic Acid Ethyl Ester; Acetate, Benzocaine; Formate, Benzocaine; Hydrobromide, Benzocaine; Hydrochloride, Benzocaine; Methanesulfonate, Benzocaine; Ethyl Aminobenzoate; Benzoic acid, 4-amino-, ethyl ester

Networked: 257 relevant articles (18 outcomes, 28 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hersh, Elliot V: 4 articles (03/2014 - 01/2003)
2.	Andersson, Lars: 3 articles (05/2007 - 01/2005)
3.	Spiller, H A: 2 articles (11/2014 - 08/2000)
4.	Jeske, Arthur H: 2 articles (12/2013 - 01/2009)
5.	Stoopler, Eric T: 2 articles (05/2013 - 01/2005)
6.	Uter, Wolfgang: 2 articles (01/2011 - 12/2005)
7.	Manchanda, Shalini: 2 articles (01/2011 - 03/2010)
8.	Vallurupalli, Srikanth: 2 articles (01/2011 - 03/2010)
9.	Sasseville, Denis: 2 articles (03/2008 - 12/2006)
10.	DeRossi, Scott S: 2 articles (01/2005 - 01/2003)

Related Diseases

1.	Pain (Aches) 01/01/2009 - "It was concluded that when the efficacy of topical benzocaine and of a combination product was compared as the sole anesthetic to facilitate acceptable pain control for placement of orthodontic temporary anchorage devices, the combination product was considerably more efficacious." 05/01/2013 - "The responders' rates (the primary efficacy parameter), defined as the percentage of participants who had an improvement in pain intensity as exhibited by a pain score reduction of at least one unit on the dental pain scale from baseline for two consecutive assessments any time between the five- and 20-minute points, were 87.3 percent, 80.7 percent and 70.4 percent, respectively, for 20 percent benzocaine gel, 10 percent benzocaine gel and vehicle gel. " 06/01/2014 - "We conducted a prospective, randomized, double-blinded, placebo-controlled study to assess whether the use of benzocaine spray during HSG is associated with reduced pain as compared with placebo. " 06/01/2014 - "This prospective, randomized, double-blinded, placebo-controlled study assessed whether the use of benzocaine spray during HSG is associated with reduced pain as compared with placebo. " 02/01/2012 - "The aim of this study was to evaluate if sucking a benzocaine lozenge was superior to a placebo lozenge in patients with pain while swallowing. "
2.	Toothache (Toothaches) 06/01/1982 - "The purpose of this investigation was to determine the efficacy of benzocaine for temporary relief of toothache. " 06/01/1982 - "Efficacy of using benzocaine for temporary relief of toothache." 01/01/2005 - "A study of benzocaine gel dosing for toothache." 01/01/2015 - "In addition, the patient reported that he also had a severe toothache for several days, which he had been self-treating with an over-the-counter oral benzocaine gel. " 01/01/2005 - "This pilot study evaluated subject compliance with a proposed OTC label with improved dosing directions for self-application of a 20% benzocaine gel for toothache pain, and assessed the methodology for evaluating efficacy in a future pivotal study of benzocaine gel. "
3.	Weight Loss (Weight Reduction) 07/01/1999 - "The PPA with benzocaine group had more adverse events than the benzocaine group (p = 0.03), the placebo group (p = 0.03), or the PPA group (p = 0.09) without additional weight loss. " 07/01/1999 - "Because benzocaine causes weight loss by altering taste and PPA by central appetite suppression, they may induce additional weight loss when combined. " 01/01/1992 - "Benzocaine gave less weight loss than PPA (P less than 0.05 ANOVA). " 01/01/1992 - "Thus, PPA is safe and effective for weight loss, appears less effective than prescription anorectics in studies exceeding 4 wk, and weight loss was not enhanced by combination with benzocaine." 07/01/1999 - "These studies explore the safety and efficacy of low-dose PPA, pseudoephedrine, and PPA with benzocaine in causing weight loss. "
4.	Otitis Media 06/01/2008 - "Use 3 drops of topical 2% lidocaine drops or benzocaine to provide rapid pain relief for children with acute otitis media." 07/01/1997 - "To determine the efficacy of Auralgan otic solution (combination product of antipyrine, benzocaine, and glycerin) compared with an olive oil placebo in the management of moderate to severe ear pain in children with acute otitis media (AOM). "
5.	Methemoglobinemia 11/01/2014 - "The rare and idiopathic nature of methemoglobinemia after benzocaine use has made study of the pathophysiologic mechanism in humans difficult. " 10/01/1994 - "This study determined the frequency and severity of benzocaine-associated methemoglobinemia in routine clinical use. " 01/01/2015 - "Given the recognized risk of methemoglobinemia associated with benzocaine use, we recommend its removal from the market in favor of safer alternatives. " 01/01/2015 - "We report a case of methemoglobinemia secondary to self-administered use of benzocaine spray. " 01/01/2015 - "An Atypical Case of Methemoglobinemia due to Self-Administered Benzocaine."

Related Drugs and Biologics

1.	Lidocaine (Xylocaine)
2.	Gels
3.	EMLA
4.	Tetracaine (Amethocaine)
5.	Pseudoephedrine
6.	Histamine (Histamine Dihydrochloride)
7.	Appetite Depressants (Anorectics)
8.	tricaine
9.	Glycerol (Glycerine)
10.	Antipyrine (Phenazone)

Related Therapies and Procedures

1.	Analgesia
2.	Tonsillectomy
3.	General Anesthesia
4.	Orthodontic Appliances
5.	Injections