Benzo(a)pyrene

A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.

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Networked: 1358 relevant articles (28 outcomes, 180 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Yian: 10 articles (06/2015 - 01/2005)
2.	You, Ming: 10 articles (06/2015 - 01/2005)
3.	Sinha, Rashmi: 10 articles (01/2013 - 08/2005)
4.	Lubet, Ronald A: 9 articles (06/2015 - 05/2003)
5.	Ramesh, Aramandla: 9 articles (05/2014 - 06/2007)
6.	Wei, Qingyi: 9 articles (01/2012 - 02/2002)
7.	Spitz, Margaret R: 9 articles (01/2011 - 02/2002)
8.	Sakthisekaran, Dhanapal: 8 articles (06/2013 - 12/2004)
9.	Ramakrishnan, G: 8 articles (11/2012 - 04/2008)
10.	Kamaraj, S: 8 articles (11/2012 - 04/2008)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1975 - "Higher doses of benzo(a)pyrene were more effective in inducing lung, liver, and stomach tumors. " 03/01/2012 - "Further, in vivo pharmacodynamic studies were carried to check the therapeutic efficacy against benzo(a)pyrene [B(a)P]-induced stomach tumors in albino mice (Balb/C strain). " 12/01/2007 - "Those 2 isomers decreased the incidence of forestomach tumors induced by benzo (a) pyrene in mice. " 10/01/2007 - "Furthermore, CF-TP inhibited benzo[a]pyrene (B[a]P)/TPA-induced skin tumor formation and decreased the incidence of tumor. " 09/16/1997 - "Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyrene-induced cancer in mice."
2.	Lung Neoplasms (Lung Cancer) 01/01/2013 - "The present study was designed to reanalyse the existing data on lung cancer mortality, incorporating revised and improved exposure estimates to BSM and to benzo[a]pyrene (B[a]P), including increments during the follow-up and a lag for latency. " 06/01/2015 - "Erratum: Ethanolic Extract of Marsdenia condurango Ameliorates Benzo[a]pyrene-induced Lung Cancer of Rats: Condurango Ameliorates BaP-induced Lung Cancer in Rats." 06/01/2014 - "Ethanolic Extract of Marsdenia condurango Ameliorates Benzo[a]pyrene-induced Lung Cancer of Rats: Condurango Ameliorates BaP-induced Lung Cancer in Rats." 04/01/2012 - "The aim of the present study is to divulge the chemopreventive and chemoprotective nature of ATRA during benzo(a)pyrene (B(a)P) induced lung cancer development in BALB/c mice. " 02/25/2006 - "The current experimental work deals with the immunomodulatory studies on the extract of Withania somnifera (L.) Dunal root powder against benzo(a)pyrene induced lung cancer in male Swiss albino mice. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/15/2016 - "Association of environmental benzo[a]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case-control study." 02/01/2014 - "Large epidemiologic studies about the relationship between benzo[a]pyrene (B[a]P) and hepatocellular carcinoma (HCC) have been limited. " 02/01/2014 - "Interaction of benzo[a]pyrene with other risk factors in hepatocellular carcinoma: a case-control study in Xiamen, China." 05/01/2012 - "Oxidative stress and cell-cycle change induced by coexposed PCB126 and benzo(a) pyrene to human hepatoma (HepG2) cells." 12/24/2011 - "Mustard extracts displayed significant anti-genotoxicity against benzo(a)pyrene in human HepG2 hepatoma cells. "
4.	Body Weight (Weight, Body) 01/01/2014 - "In the present study, male transgenic lacI mice at different ages (7, 25 and 60 days old) were treated with a known environmental mutagen (benzo[a]pyrene, B[a]P) at different doses (0, 50, 200 or 300 mg/kg body weight). " 08/01/1999 - "In an extended OECD 407 study protocol, including immune parameters, male Riv:Tox Wistar SPF rats were treated for 35 days with benzo[a]pyrene (B[a]p) (3, 10, 30, or 90 mg/kg body weight) by gavage. " 12/01/2011 - "Muta™Mouse were dosed daily for 28 days with benzo[a]pyrene (BaP; 0, 25, 50 and 75 mg/kg body weight/day) by oral gavage. " 06/01/2011 - "To investigate the effect of Ax on the metabolic activation of a typical promutagen, benzo[a]pyrene by CYP1A, we orally administrated Ax-containing oil (100 mg Ax/kg body weight/day for 3 days) to male Wistar rats. " 10/01/2008 - "Benzo[a]pyrene (B[a]P), a well-known mutagen, was given at a single dose of 100 mg/kg body weight intraperitoneally. "
5.	Carcinoma (Carcinomatosis) 01/01/1980 - "Cervical atypias and carcinoma were induced by local application of benzo(a)pyrene (BP) and mitosis was arrested with vincrotal number of cells in all layers as well as the proportion of dividing cells in the parabasal layer were significantly greater in atypias and invasin cell production in that layer." 01/01/2009 - "Intra-pulmonary injection of 3,4-benzopyrene steady induced lung carcinoma at a success rate of 75%. " 10/14/2008 - "Female ICR mice were gavaged with benzo[a]pyrene (BaP) to induce forestomach carcinoma. " 10/01/2007 - "Activation of the AHR by the genotoxic carcinogen benzo(a)pyrene (BaP) increased L1 expression in human cervical carcinoma (HeLa) cells, human microvascular endothelial cells (HMEC), mouse vascular smooth muscle cells (mVSMC) and mouse embryonic kidney cells (mK4). " 12/01/2004 - "In the present communication, the expression profile of HABP1 was investigated from initiation to progression of epidermal carcinoma in mice, induced by benzo[a]pyrene (B[a]P) exposure. "

Related Drugs and Biologics

1.	baicalein
2.	polylactic acid-polyglycolic acid copolymer (PLGA)
3.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
4.	Smoke
5.	DNA Adducts
6.	Capsaicin (Zostrix)
7.	DNA (Deoxyribonucleic Acid)
8.	Cytochrome P-450 CYP1A1 (CYP1A1)
9.	Carcinogens
10.	Enzymes

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Subcutaneous Injections
3.	Oral Administration
4.	Lasers (Laser)
5.	Transplantation (Transplant Recipients)