Benzimidazoles

01/01/2006 - "We suggest that instructing children and adults corrects personal habits which are conducive to infection and can be an effective and safe substitute for repeated deworming, reducing the opportunity for the emergence of drug-resistant helminthes, which should prolong the time benzimidazoles may be used for treatment of geohelminth infection."
03/31/2013 - "A recurrent problem in the control of whipworm (Trichuris spp.) infections in many animal species and man is the relatively low efficacy of treatment with a single application of benzimidazoles (BZs). "
01/01/1986 - "Efficacy of benzimidazoles against larval Ancylostoma caninum infection in mice."
04/01/2014 - "The single-dose benzimidazoles used against Trichuris trichiura infections in humans are not satisfactory. "
07/01/2013 - "Benzimidazoles (BZ) are used to control infections of the equine roundworm Parascaris equorum and the poultry roundworm Ascaridia galli. "

02/01/2004 - "Even if some reports of successful therapy with benzimidazoles have been described, the treatment of choice is the surgical excision of the cyst. "
07/01/2012 - "Treatment is based on the surgical removal of the cysts in combination with anti-parasite treatment by benzimidazoles (Albendazol, Mebendazol). "
10/01/2005 - "The degenerative changes recorded, which began significantly earlier in the lung cysts than in abdominal cysts, indicate serious damage to the cysts and the parasiticidal, curative effect of each of the two benzimidazoles employed."
02/01/2003 - "Alternative treatment should be PAIR but only if the cysts cannot be treated with benzimidazoles. "
01/01/1992 - "A clinical-radiological evaluation of benzimidazoles in the management of Echinococcus granulosus cysts."

10/01/2006 - "Benzimidazoles are not active against Enterocytozoon bieneusi, the most common cause of human microsporidiosis. "
10/01/1995 - "The need for an effective compound for the prevention and treatment of cryptosporidiosis in humans and animals has led to the testing of benzimidazoles based on reports that albendazole was clinically effective against related protozoan parasites causing microsporidiosis in humans. "
10/01/2006 - "Current therapies for microsporidiosis include benzimidazoles, which bind tubulin-inhibiting microtubule assembly, and fumagillin and its derivatives, which bind and inhibit methionine amino peptidase type 2 (MetAP2). "

10/01/1995 - "Activity of benzimidazoles against cryptosporidiosis in neonatal BALB/c mice."
10/01/1995 - "The need for an effective compound for the prevention and treatment of cryptosporidiosis in humans and animals has led to the testing of benzimidazoles based on reports that albendazole was clinically effective against related protozoan parasites causing microsporidiosis in humans. "
06/14/1986 - "For treatment of intestinal protozoa, ornidazole (or other benzimidazoles), diloxanide furoate and co-trimoxazole are drugs of first choice; at present spiramycin is recommended for treatment of cryptosporidiosis in AIDS patients. "

12/01/2012 - "Anthelmintic needs include, first, a macrofilaricidal regimen that speeds up elimination, is safe to use in regions of Onchocerca volvulus and Loa loa coendemicity, and provides a rapid method to resolve infections introduced into previously controlled areas; second, a replacement of praziquantel for schistosomiasis should a resistance arise; third, formulations of praziquantel to enhance compliance, and pediatric formulations for preschool children; fourth, a regimen that provides high efficacy against Trichuris trichiura (new anthelmintic, prolonged dosing strategy or anthelmintic combinations); fifth, pediatric formulations of albendazole and mebendazole compatible with elimination operations; and sixth, an alternative to benzimidazoles in the anticipation of the development of drug resistance. "