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Lindane (gamma-Hexachlorocyclohexane)

An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.

Also Known As:

gamma-Hexachlorocyclohexane; Kwell; Scabene; BHC Insecticide; Chinoin Brand of Lindane; Delitex; Gamma-666; Gammexane; Hexachlorane; Infectopharm Brand of Lindane; Jacutin; PMS-Lindane; Pharmascience Brand of Lindane; Scabecid; Scabisan; Stiefel Brand of Lindane; Tetocid; Gamma 666; Gamma666; Hexachloride, Benzene; Hexachloride, gamma-Benzene; Insecticide, BHC; PMS Lindane; PMSLindane; gamma Benzene Hexachloride; gamma Hexachlorocyclohexane; Benzene Hexachloride; Hexachlorocyclohexane; gamma-Benzene Hexachloride; Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-

Networked: 477 relevant articles (24 outcomes, 52 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Halogenated Hydrocarbons: 31
    - Chlorinated Hydrocarbons: 157
      - Lindane: 477
        beta-hexachlorocyclohexane: 39
        1,3,4,5,6-pentachlorocyclohexene-1-oxide: 33
        hexachlorocyclohexane x-factor: 29
        alpha-hexachlorocyclohexane: 21
        delta-hexachlorocyclohexane: 9
        fentiuram: 1
        2,3,4,5,6,6-hexachloro-2,4-cyclohexadienone
        ABOL-X
        Agronex
        HCH ointment
        kartox
        pentachlorocyclohexene
        pentalidol

Experts

1.	Stanojlović, Olivera: 5 articles (03/2013 - 04/2008)
2.	Mathur, P P: 5 articles (01/2009 - 06/2001)
3.	Goldust, Mohamad: 4 articles (01/2015 - 01/2012)
4.	Hoppin, Jane A: 4 articles (01/2014 - 02/2007)
5.	Olea, Nicolás: 3 articles (07/2015 - 04/2011)
6.	Rezaee, Elham: 3 articles (09/2014 - 01/2012)
7.	Sandler, Dale P: 3 articles (01/2014 - 05/2007)
8.	Alavanja, Michael C R: 3 articles (01/2014 - 02/2007)
9.	Parmar, Devendra: 3 articles (10/2013 - 02/2008)
10.	Bhatt, Devendra Kumar: 3 articles (11/2012 - 02/2010)

Related Diseases

1.	Scabies (Sarcoptic Mange) 09/01/2000 - "Those who were not cured were then treated with 1% lindane lotion topically, as were the prison staff who had scabies. " 10/01/1983 - "A trial of three treatment schedules, consisting of 1% gamma benzene hexachloride (GBH) lotion applied head to toe and left on the body for 2, 6, or 12 to 24 hours was conducted on an island of 2,076 persons, approximately 70% of whom had clinical evidence of scabies. " 08/01/2015 - "We suggest that a twice-weekly schedule (on consecutive days) of 1% lindane treatment lasting at least 2 weeks is required to clear scabies. " 08/01/2015 - "Efficacy and safety of a lindane 1% treatment regimen for scabies, confirmed by dermoscopy-guided skin scraping with microscopic examination." 09/01/2011 - "Higher serum total lymphocyte count and topical use of γ-benzene hexachloride were associated with lower risk of scabies recurrence. "
2.	Seizures (Seizure) 01/01/2010 - "The aim of this study was to investigate the dynamics of lipid peroxidation and the possible correlation between lipid peroxidation in different brain regions and behavioral manifestations in lindane-induced seizures in rats. " 04/01/2008 - "We report a study on the relation between open-field behavior and electroencephalographic (EEG) changes during lindane-induced seizures in 2-month-old adult male Wistar rats. " 03/01/1995 - "The impact of intermittent exposure to lindane on behavioral seizure development and subsequent electrical kindling was assessed in the present study. " 08/01/1989 - "The main objective of this work was to study the role of the GABAergic system on the convulsions elicited by the organochlorine insecticide lindane. " 01/01/1985 - "Lindane-exposed rats tended to have longer and more severe seizures than did non-exposed rats on each trial during kindling acquisition. "
3.	Body Weight (Weight, Body) 05/01/1988 - "The observed stereoselective effects of HCH isomers on core temperature and body weight could be a useful model to study the mechanisms of lindane neurotoxicity at low subconvulsant doses." 09/01/2015 - "Al-Qassim region population's average estimated daily intake (EDI) was between 0.0 and 12.74 μg/kg body weight/day, and the hazard index [EDI/acceptable daily intake (ADI)] was higher than unity for ΣDDT and lindane in some samples. " 10/01/2013 - "Adult male albino wistar rats were treated orally with different doses (2.5- or 5.0- or 10- or 15 mg/kg/body weight) of lindane daily for 4 days. " 01/31/2009 - "Animals were administered with a single dose of lindane (5mg/kg body weight) and sacrificed at specific post-treatment intervals (0, 3, 6, 12, 24 and 72h). " 02/28/2008 - "Animals were administered with a single dose of lindane (5mg/kg body weight) and terminated at specific post-treatment intervals (0h, 3h, 6h, 12h, 24h and 72h) to analyze the early testicular response. "
4.	Lice Infestations (Pediculosis) 01/01/2004 - "There were 528 reported human exposures to lindane for pediculosis. " 01/01/2004 - "Data on all lindane exposures for pediculosis reported to the Texas Poison Center Network were analyzed. " 01/01/2004 - "Epidemiology of lindane exposures for pediculosis reported to Poison Centers in Texas, 1998-2002." 09/01/2000 - "The side effects of lindane in children with pediculosis were reported. " 09/01/2000 - "[Side effects of lindane in children with pediculosis]."
5.	Infection 01/15/2008 - "This study was undertaken to assess the prevalence of and epidemiological factors associated with, head lice infections in Iranian primary schools in 2006 and evaluate data on the therapeutic efficacy of lindane shampoo. " 01/01/1985 - "The infection with ecthyma contagiosum in chamois and the successful treatment with hexachlorocyclohexane are reported." 06/01/2010 - "DDT and Lindane (gamma-HCH) which were used until 1999 in Mexico, have provided great benefits in the combat of vectors that spread infection-borne diseases and in agriculture for crop protection. " 01/01/2010 - "Since the discovery of insecticide properties of DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane) and HCH (hexachlorocyclohexane), they have provided great benefits to humans in sanitary actions to combat the spread of infection-borne disease vectors. " 10/01/1984 - "DMN-demethylase II followed the same general pattern, but it reached its peak 20 days after infection and declined at a slower rate than DMN-demethylase I. The effects of lindane, an organochlorine insecticide, were also studied on these two enzymes in uninfected mice and in S. "

Related Drugs and Biologics

1.	Ivermectin (Mectizan)
2.	Permethrin (Ambush)
3.	Lindane (gamma-Hexachlorocyclohexane)
4.	benzyl benzoate (Ansar)
5.	Ethanol (Ethyl Alcohol)
6.	Pentylenetetrazole (Metrazol)
7.	Heavy Metals
8.	Valproic Acid (Valproate, Semisodium)
9.	Sulfur
10.	Ochratoxins

Related Therapies and Procedures

1.	Oral Administration
2.	Aftercare (After-Treatment)
3.	Intraperitoneal Injections
4.	Injections
5.	Intravenous Infusions