Benactyzine

A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.

Also Known As:

Networked: 57 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kassa, J: 2 articles (01/2001 - 11/2000)
2.	Balali-Mood, Mahdi: 1 article (01/2012)
3.	Moshiri, Mohammd: 1 article (01/2012)
4.	Darchini-Maragheh, Emadodin: 1 article (01/2012)
5.	Gilat, Eran: 1 article (02/2008)
6.	Kapon, Joseph: 1 article (02/2008)
7.	Raveh, Lily: 1 article (02/2008)
8.	Brandeis, Rachel: 1 article (02/2008)
9.	Weissman, Ben Avi: 1 article (02/2008)
10.	Stavitsky, Ziv: 1 article (02/2008)

Related Diseases

1.	Poisoning 08/01/1982 - "The present results suggest that the drug is unsuitable for treatment for oganophosphate poisoning when continuous performance is required, although a definitive test of ths suggestion would require that performance should be tested when benactyzine and the organophosphate of interest were combined." 02/01/1965 - "[BENACTYZINE POISONING IN A 3-YEAR-OLD BOY]." 02/01/2001 - "Benactyzine is used to treat organophosphate poisoning and drofenine acts on smooth muscle to stop muscle spasms. " 02/15/2008 - "Efficacy of antidotal treatment against sarin poisoning: the superiority of benactyzine and caramiphen." 05/01/1996 - "The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats."
2.	Seizures (Seizure) 01/01/1985 - "Brain regional activity and damage associated with organophosphate induced seizures: effects of atropine and benactyzine." 02/15/2008 - "We report here on the protection provided by post-exposure antidotal treatments against a lethal dose of sarin (1.2xLD50) by scopolamine, benactyzine, trihexyphenidyl or caramiphen, administered 5, 10 or 20 min after the initiation of convulsions. " 01/01/2000 - "When given 40 min after seizure onset, diazepam was the most potent compound tested, followed by scopolamine, benactyzine and biperiden; atropine was not effective when tested 40 min after seizure onset. " 01/01/1993 - "Scopolamine and atropine showed a dose- and time-dependent effectiveness; the longer the seizure progressed the higher the dose of drug required to terminate the seizure, with eventual loss of anticonvulsant activity if the seizure had progressed for 40 min. In contrast, benactyzine and trihexyphenidyl showed a third profile of activity: There was a smaller increase in drug dosage required for anticonvulsant activity as seizure duration increased, and both drugs could terminate seizures that had progressed for 40 min. The early anticonvulsant action of anticholinergics is interpreted as a specific effect that blocks the primary cholinergic excitatory drive that initiates, and first maintains, nerve agent seizures. " 04/01/1987 - "In the presence of 40 mg/kg of atropine, ED50 values for oxotremorine were shifted more than 12-fold for lacrimation, salivation and tremor, whereas convulsions and death were maximally altered by a factor of 2. Scopolamine, benactyzine and benztropine were also incapable of completely preventing tremor, convulsions and death induced by 10 or 15 mg/kg of oxotremorine. "
3.	Water Intoxication 03/01/1985 - "Experiments on rats with experimental brain edema under water intoxication were made to study the effects of the neuroleptics aminazine and propazine, the central M-cholinoblocker amizyl and the alpha-adrenoblocker phentolamine on the time-course of the recovery of cortical electric activity after passing of the wave of Leao's spreading depression (SD). "
4.	Urinary Incontinence 11/13/1992 - "In a study aimed toward developing new, selective antimuscarinic drugs with potential utility in the treatment of urinary incontinence associated with bladder muscle instability, a series of N-substituted 5-(aminomethyl)-3,3-diphenyl-2(3H)-furanones, conformationally-constrained lactone relatives of benactyzine, was prepared. "
5.	Brain Edema (Cerebral Edema) 03/01/1985 - "Experiments on rats with experimental brain edema under water intoxication were made to study the effects of the neuroleptics aminazine and propazine, the central M-cholinoblocker amizyl and the alpha-adrenoblocker phentolamine on the time-course of the recovery of cortical electric activity after passing of the wave of Leao's spreading depression (SD). "

Related Drugs and Biologics

1.	HI 6 (H16)
2.	Soman
3.	Oximes
4.	Atropine (Hyoscyamine)
5.	Biperiden (Akineton)
6.	Sarin
7.	Obidoxime Chloride (Obidoxime)
8.	Mevinphos
9.	BI 6
10.	pralidoxime (Protopam Chloride)

Related Therapies and Procedures

1.	Therapeutics
2.	Hemoperfusion
3.	Electrodes (Electrode)
4.	Analgesia