A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.
Also Known As:
Amizil; Amizyl; Lucidil; Smith & Nephew Brand of Benactyzine Hydrochloride; Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester
Networked: 57 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Kassa, J: 2 articles (01/2001 - 11/2000)
2. Balali-Mood, Mahdi: 1 article (01/2012)
3. Moshiri, Mohammd: 1 article (01/2012)
4. Darchini-Maragheh, Emadodin: 1 article (01/2012)
5. Gilat, Eran: 1 article (02/2008)
6. Kapon, Joseph: 1 article (02/2008)
7. Raveh, Lily: 1 article (02/2008)
8. Brandeis, Rachel: 1 article (02/2008)
9. Weissman, Ben Avi: 1 article (02/2008)
10. Stavitsky, Ziv: 1 article (02/2008)

Related Diseases

1. Poisoning
2. Seizures (Seizure)
01/01/1985 - "Brain regional activity and damage associated with organophosphate induced seizures: effects of atropine and benactyzine."
02/15/2008 - "We report here on the protection provided by post-exposure antidotal treatments against a lethal dose of sarin (1.2xLD50) by scopolamine, benactyzine, trihexyphenidyl or caramiphen, administered 5, 10 or 20 min after the initiation of convulsions. "
01/01/2000 - "When given 40 min after seizure onset, diazepam was the most potent compound tested, followed by scopolamine, benactyzine and biperiden; atropine was not effective when tested 40 min after seizure onset. "
01/01/1993 - "Scopolamine and atropine showed a dose- and time-dependent effectiveness; the longer the seizure progressed the higher the dose of drug required to terminate the seizure, with eventual loss of anticonvulsant activity if the seizure had progressed for 40 min. In contrast, benactyzine and trihexyphenidyl showed a third profile of activity: There was a smaller increase in drug dosage required for anticonvulsant activity as seizure duration increased, and both drugs could terminate seizures that had progressed for 40 min. The early anticonvulsant action of anticholinergics is interpreted as a specific effect that blocks the primary cholinergic excitatory drive that initiates, and first maintains, nerve agent seizures. "
04/01/1987 - "In the presence of 40 mg/kg of atropine, ED50 values for oxotremorine were shifted more than 12-fold for lacrimation, salivation and tremor, whereas convulsions and death were maximally altered by a factor of 2. Scopolamine, benactyzine and benztropine were also incapable of completely preventing tremor, convulsions and death induced by 10 or 15 mg/kg of oxotremorine. "
3. Water Intoxication
4. Urinary Incontinence
5. Brain Edema (Cerebral Edema)

Related Drugs and Biologics

1. HI 6 (H16)
2. Soman
3. Oximes
4. Atropine (Hyoscyamine)
5. Biperiden (Akineton)
6. Sarin
7. Obidoxime Chloride (Obidoxime)
8. Mevinphos
9. BI 6
10. pralidoxime (Protopam Chloride)

Related Therapies and Procedures

1. Therapeutics
2. Hemoperfusion
3. Electrodes (Electrode)
4. Analgesia