Benactyzine

A centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior.

Also Known As:

Networked: 63 relevant articles (6 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kassa, J: 2 articles (01/2001 - 11/2000)
2.	Bloch-Shilderman, E: 1 article (01/2019)
3.	Cohen, L: 1 article (01/2019)
4.	Egoz, I: 1 article (01/2019)
5.	Gez, R: 1 article (01/2019)
6.	Gutman, H: 1 article (01/2019)
7.	Nili, U: 1 article (01/2019)
8.	Rabinovitz, I: 1 article (01/2019)
9.	Yacov, G: 1 article (01/2019)
10.	Balali-Mood, Mahdi: 1 article (11/2012)

Related Diseases

1.	Poisoning 02/01/1965 - "[BENACTYZINE POISONING IN A 3-YEAR-OLD BOY]." 08/01/1982 - "The present results suggest that the drug is unsuitable for treatment for oganophosphate poisoning when continuous performance is required, although a definitive test of ths suggestion would require that performance should be tested when benactyzine and the organophosphate of interest were combined." 10/27/2022 - "The combined release of both compounds in the brain offers several advantages over the current OP poisoning treatment protocol: improved efficacy and safety profile (where the inhibitory properties of GABA are expected to counteract the anticholinergic cognitive adverse effects of benactyzine) and enhanced chemical stability compared to benactyzine alone. " 02/15/2008 - "Efficacy of antidotal treatment against sarin poisoning: the superiority of benactyzine and caramiphen." 05/01/1996 - "The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats."
2.	Tetanus 01/01/1978 - "Experiments were conducted on rabbits with tetanus intoxication induced by the intravenous injection of a lethal dose of the toxin; a study was made of the therapeutic efficacy of the acetylcholinesterase reactivators--dipyroxim and isonitrosine, and also of the central cholinolytics--amizyl and diphacyl. "
3.	Water Intoxication 03/01/1985 - "Experiments on rats with experimental brain edema under water intoxication were made to study the effects of the neuroleptics aminazine and propazine, the central M-cholinoblocker amizyl and the alpha-adrenoblocker phentolamine on the time-course of the recovery of cortical electric activity after passing of the wave of Leao's spreading depression (SD). "
4.	Urinary Incontinence 11/13/1992 - "In a study aimed toward developing new, selective antimuscarinic drugs with potential utility in the treatment of urinary incontinence associated with bladder muscle instability, a series of N-substituted 5-(aminomethyl)-3,3-diphenyl-2(3H)-furanones, conformationally-constrained lactone relatives of benactyzine, was prepared. "
5.	Brain Edema (Cerebral Edema) 03/01/1985 - "Experiments on rats with experimental brain edema under water intoxication were made to study the effects of the neuroleptics aminazine and propazine, the central M-cholinoblocker amizyl and the alpha-adrenoblocker phentolamine on the time-course of the recovery of cortical electric activity after passing of the wave of Leao's spreading depression (SD). "

Related Drugs and Biologics

1.	Cholinergic Antagonists (Anticholinergics)
2.	Oximes
3.	asoxime chloride (H16)
4.	Soman
5.	Acetylcholinesterase
6.	adiphenine
7.	Atropine
8.	Sarin
9.	Obidoxime Chloride (Obidoxime)
10.	Biperiden (Akineton)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Therapeutics
3.	Hemoperfusion
4.	Analgesia