Bee Venoms (Bee Venom)

Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.

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Networked: 536 relevant articles (39 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Jun: 28 articles (10/2015 - 07/2002)
2.	Park, Kwan-Kyu: 16 articles (06/2015 - 12/2008)
3.	Chen, J: 14 articles (01/2014 - 01/2000)
4.	Chen, Hui-Sheng: 12 articles (09/2013 - 05/2003)
5.	Bae, Hyunsu: 11 articles (11/2015 - 01/2009)
6.	Han, Sang-Mi: 11 articles (11/2015 - 03/2008)
7.	Chang, Young-Chae: 11 articles (06/2015 - 12/2006)
8.	Beitz, Alvin J: 11 articles (01/2013 - 05/2002)
9.	Roh, Dae-Hyun: 10 articles (07/2015 - 03/2003)
10.	Lee, Jang-Hern: 9 articles (07/2015 - 03/2003)

Related Diseases

1.	Pain (Aches) 12/01/2014 - "Bee venom pharmacopuncture: an effective treatment for complex regional pain syndrome." 08/06/2004 - "Whole bee venom (WBV)-induced pain model has been reported to be very useful for the study of pain. " 09/24/2010 - "This study was designed to investigate the role of sympathetic postganglionic neurons in inflammatory pain induced by bee venom (BV). " 10/29/2007 - "Our previous studies have established the idea that different types of pain induced by subcutaneous bee venom (BV) injection might be mediated by different spinal signaling pathways. " 09/28/1998 - "In order to study central neuronal components involved in subcutaneous (s.c.) bee venom-induced persistent pain (a new tonic pain model), we use Fos immunostaining technique to study the spatial and temporal patterns of neuronal activity in the spinal cord of anesthetized rats. "
2.	Hypersensitivity (Allergy) 09/01/2014 - "For bee venom allergy, improvements in molecular allergy diagnostics have shown promising results and their implementation in clinical practice is planned. " 09/01/2013 - "The high occurrence of bee attacks involving potentially fatal toxic and allergic reactions in humans and the prospect of developing novel pharmaceuticals make honey bee venom an attractive target for proteomic studies. " 01/01/2008 - "The aim of this study was to determine the incidence of bee venom allergy in German beekeepers, to explore risk factors for bee venom allergy in this group, and to determine which factors best predicted severe reactions. " 12/01/2007 - "In the present study, by using the bee venom (BV) model of nociception and hypersensitivity, antinociceptive effects of PF were evaluated by intraperitoneal administration in conscious rats. " 01/01/1988 - "[Epidemiological and clinical study on bee venom allergy among beekeepers]."
3.	Bites and Stings (Sting) 06/01/2008 - "Combined application of bee-venom therapy and medication is superior to simple use of medication in relieving RA, and when bee-sting therapy used, the commonly-taken doses of western medicines may be reduced, and the relapse rate gets lower." 02/01/2002 - "The purpose of this study was to investigate the long-term predictive value of sequential bee-sting challenges with respect to the ability to predict future sting reactions in bee-venom (BV) allergic children. " 12/01/1995 - "The reduction in systemic reactions to subsequent bee stings was significantly better in the study group receiving bee venom than in an historic control group treated with whole bee extract (p = 0.03). " 12/01/2013 - "However, in the subacute stage, unlike bee stings, we see the characteristic histological "flame" figures resulting from eosinophilic stimulation induced by excessive bee venom exposure. " 10/01/2013 - "Of the group of beekeepers, 116 were men (83%) and 23 women, average age was 39.3 years, had atopic family history 28% and personal atopy 13%, average time of exposure to bee stings was 10.9 years, skin tests with honey-bee venom were positive in 16.5% and 11% at 1 mcg/mL and 0.1 mcg/mL, respectively. "
4.	Inflammation 06/01/2015 - "The aim of the present study was to investigate anti-inflammatory properties of bee venom in skin inflammation induced by P. " 06/01/2015 - "However, there has not yet been a robust trial to prove the therapeutic effect of bee venom in skin inflammation. " 08/01/2015 - "Bee Venom Acupuncture Augments Anti-Inflammation in the Peripheral Organs of hSOD1G93A Transgenic Mice." 06/01/2015 - "Effects of bee venom against Propionibacterium acnes-induced inflammation in human keratinocytes and monocytes." 06/01/2014 - "Bee venom is a natural compound produced by the honey bee (Apis mellifera), and has been reported as having the biological and pharmacological activities, including anti-bacterial, anti-viral and anti-inflammation. "
5.	Arthritis (Polyarthritis) 09/01/2009 - "Bee venom therapy is an alternative therapy that is believed to be effective for various kinds of arthritis. " 07/01/2010 - "Several recent studies have shown that bee venom (BV) has an anti-nociceptive and anti-inflammatory effect on arthritis. " 07/01/2005 - "The aim of this study was to assess the inhibitory effect of whole bee venom (BV) on adjuvant-induced arthritis in the rat. " 10/01/2011 - "Since ancient times honey bee venom has been used for the treatment of chronic inflammatory disease, especially arthritis. " 07/01/2010 - "The assessment of bee venom responses in an experimental model of mono-arthritis using Tc-99m DPD bone scintigraphy."

Related Drugs and Biologics

1.	Melitten (Melittin)
2.	Antibodies
3.	Venoms
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Proteins (Proteins, Gene)
6.	Nitrates
7.	Immunoglobulin G (IgG)
8.	Wasp Venoms (Venom, Wasp)
9.	Allergens
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Immunotherapy
2.	Acupuncture Points (Acupuncture Point)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Traditional Medicine (Folk Remedies)
5.	Apitherapy