BCG Vaccine

An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.

Also Known As:

Networked: 891 relevant articles (123 outcomes, 98 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Britton, Warwick J: 7 articles (03/2015 - 01/2004)
2.	Triccas, James A: 7 articles (03/2015 - 01/2004)
3.	Xing, Zhou: 7 articles (01/2015 - 07/2002)
4.	Aaby, Peter: 7 articles (10/2014 - 02/2007)
5.	Huygen, Kris: 7 articles (01/2008 - 11/2004)
6.	Fan, Xionglin: 6 articles (12/2015 - 08/2011)
7.	Zhang, Ying: 6 articles (08/2015 - 04/2002)
8.	Benn, Christine Stabell: 6 articles (10/2014 - 02/2007)
9.	Orme, Ian M: 6 articles (09/2014 - 11/2004)
10.	Andersen, Peter: 6 articles (08/2014 - 02/2002)

Related Diseases

1.	Tuberculosis (Tuberculoses) 08/01/2015 - "The protective efficacy of bacille Calmette Guérin (BCG) vaccine against tuberculosis (TB) in adults is highly controversial even though the BCG vaccine has been available for more than 90 years. " 12/01/2014 - "The Bacille Calmette-Guerin (BCG) vaccine is the only vaccine proved to be effective against tuberculosis and it remains the most commonly used vaccine worldwide. " 08/01/2011 - "The efficacy of Bacillus Calmette-Guérin (BCG) vaccine in preventing adult tuberculosis (TB) is highly variable. " 10/01/2007 - "The vaccine provided remarkable protective efficacy in mouse compared to BCG vaccine, and improved the histopathological tuberculosis lesions. " 03/01/2015 - "BCG vaccine is not providing complete protection against tuberculosis. "
2.	Infection 04/01/2004 - "The global situation has become precarious due to various factors such as the variable efficacy of the Bacille Calmette-Guerin (BCG) vaccine, drug resistance, delay in diagnosis, association with HIV, and other factors, creating a long-lasting reservoir of impending disease and infection. " 02/01/2011 - "These results support our previous study using Japanese flounder and suggest that BCG vaccine is also effective against Mycobacterium sp. infection in amberjack." 03/15/2012 - "Mycobacterium tuberculosis infection claims approximately 2 million lives per year, and improved efficacy of the BCG vaccine remains a World Health Organization priority. " 06/24/2011 - "Overexpression of Rv3097c in Mycobacterium bovis BCG abolished the efficacy of BCG vaccine to protect against Mycobacterium tuberculosis infection in mice." 05/01/2007 - "bovis BCG vaccine offers only short-term protection against experimental footpad infection of C57BL/6 mice with M. "
3.	Pulmonary Tuberculosis 01/01/2012 - "The Bacille-Calmette Guérin (BCG) vaccine does not provide consistent protection against adult pulmonary tuberculosis (TB) worldwide. " 07/15/2010 - "Mutations that arose in bacille Calmette-Guérin (BCG) daughter strains during decades of in vitro cultivation have long been suspected of reducing the efficacy of the BCG vaccine against pulmonary tuberculosis. " 02/01/2010 - "Because the Mycobacterium bovis Bacilli-Calmette-Guerin (BCG) vaccine fails to protect adults from pulmonary tuberculosis, there is an urgent need for improved vaccine formulations. " 02/01/2002 - "The efficacy of Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine against pulmonary tuberculosis (TB) varies enormously in different populations. " 10/01/2012 - "Clinical trials worldwide have proved the inadequacy of the BCG vaccine in preventing the manifestation of pulmonary tuberculosis in adults. "
4.	Leprosy (Hansen's Disease) 02/22/1992 - "In an attempt to find a vaccine that gives greater and more consistent protection against leprosy than BCG vaccine, we compared BCG with and without killed Mycobacterium leprae in Venezuela. " 08/01/1993 - "Protective efficacy of BCG vaccine against leprosy in southern Malaŵi." 02/01/2010 - "The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. " 02/01/2009 - "Neither one nor two doses of the bacille Calmette-Guérin (BCG) vaccine provides protection against adult pulmonary TB, despite protecting against leprosy. " 08/01/1993 - "This paper describes a matched case-control study to determine the efficacy of BCG vaccine in preventing the occurrence of leprosy in southern Malaŵi, a previously unstudied area. "
5.	Meningeal Tuberculosis (Tuberculous Meningitis) 03/01/2012 - "The BCG vaccine is most effective in preventing pediatric TB, in particular, miliary TB and tuberculous meningitis. " 06/01/1993 - "Case series evaluation of BCG vaccine efficacy against tubercular meningitis in children in Delhi." 09/01/1989 - "A field evaluation of efficacy of BCG vaccine to prevent tubercular meningitis was undertaken in a case control study in Delhi during 1988-89. " 08/01/2009 - "BCG vaccine has protective effect for preventing tuberculous meningitis. " 10/01/2007 - "BCG vaccine protects against miliary/meningeal tuberculosis, but the mechanism of protection is unknown. "

Related Drugs and Biologics

1.	Vaccines
2.	DNA (Deoxyribonucleic Acid)
3.	Tuberculin (PPD)
4.	Antigens
5.	Lactoferrin
6.	Carbon Monoxide
7.	Interleukin-12 (IL 12)
8.	Measles Vaccine
9.	Pertussis Vaccine
10.	Interleukin-18 (Interleukin 18)

Related Therapies and Procedures

1.	Immunotherapy
2.	Drug Therapy (Chemotherapy)
3.	Intravesical Administration
4.	Aftercare (After-Treatment)
5.	Chemoprevention