Balkan Nephropathy (Balkan Endemic Nephropathy)

A form of chronic interstitial nephritis that is endemic to limited areas of BULGARIA, the former YUGOSLAVIA, and ROMANIA. It is characterized by a progressive shrinking of the KIDNEYS that is often associated with uroepithelial tumors.
Also Known As:
Balkan Endemic Nephropathy; Nephropathy, Balkan Endemic; Endemic Nephropathy, Balkan; Nephropathy, Balkan
Networked: 189 relevant articles (0 outcomes, 16 trials/studies)

Disease Context: Research Results

Related Diseases

1. Kidney Diseases (Kidney Disease)
2. Carcinoma (Carcinomatosis)
3. Glomerulonephritis
4. Poisoning
5. Nephrosclerosis


1. Arlt, Volker M: 20 articles (11/2015 - 10/2002)
2. Schmeiser, Heinz H: 19 articles (11/2015 - 10/2002)
3. Frei, Eva: 12 articles (11/2015 - 01/2008)
4. Stiborová, Marie: 10 articles (11/2015 - 11/2007)
5. Phillips, David H: 9 articles (07/2014 - 11/2007)
6. Stiborova, Marie: 7 articles (07/2014 - 10/2002)
7. Pfohl-Leszkowicz, Annie: 6 articles (12/2009 - 10/2002)
8. Jelaković, Bojan: 5 articles (06/2015 - 07/2007)
9. Stefanovic, Vladisav: 5 articles (08/2014 - 01/2007)
10. Castegnaro, Marcel: 5 articles (09/2007 - 04/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Balkan Nephropathy:
1. aristolochic acid I (aristolochic acid)IBA
2. beta 2-Microglobulin (beta 2 Microglobulin)IBA
3. MycotoxinsIBA
4. SeleniumIBA
5. DNA (Deoxyribonucleic Acid)IBA
03/01/2010 - "DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. "
12/01/2009 - "It discusses the differences between the epidemiology of Balkan endemic nephropathy (BEN) and aristolochic acid nephropathy (AAN); OTA and AA carcinogenicity; clinical and pathological effects induced by OTA and AA; sources of OTA contamination (food, air, drinking water); OTA- and AA-DNA adduct formation; the role of genetic polymorphisms; and the risk for young children."
06/15/2015 - "Here we report a whole-exome sequencing screen performed on DNA from formalin-fixed, paraffin-embedded renal cell carcinomas (RCC) arising in chronic renal disease patients from a Balkan endemic nephropathy (EN) region. "
07/01/2007 - "To re-examine serum complement and immunoglobulin levels in patients with Balkan Endemic Nephropathy (BEN) in the early stage of the disease; to study autoantibodies (anti-thyroid, anti-smooth muscle, anti-mitochondrial, anti-parietal, anti-nuclear, and anti-DNA) in these patients; and, finally, to re-asses the immunohistology in kidney biopsies from BEN patients. "
09/01/2007 - "To find out whether ochratoxin A (OTA), citrinin (CIT), aristolochic acids (AA) are etiologic agents of Balkan endemic nephropathy (BEN) or Chinese herbal nephrotoxicity, and associated urinary tract tumor (UTT), we have compared (i) in human kidney cell culture, the DNA adduct formation and persistence of OTA/CIT and AA adducts (ii) analyzed DNA adduct in several tumors from human kidney suspected to be exposed to either OTA and CIT, or AAs (iii) analyzed OTA, CIT, and AA in food. "
6. CreatinineIBA
7. CoalIBA
8. Cytochrome P-450 CYP2B1 (PROD)IBA
9. Biological Markers (Surrogate Marker)IBA
10. Genetic Markers (Genetic Marker)IBA

Therapies and Procedures

1. Renal Dialysis (Hemodialysis)
2. Renal Replacement Therapy (Therapies, Renal Replacement)
3. Kidney Transplantation
4. Transplants (Transplant)
5. Transplantation (Transplant Recipients)