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Babinski Reflex (Extensor Plantar Response)

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An abnormal reflex consisting of dorsiflexion of the great toe and abduction of the other toes in response to cutaneous stimulation of the plantar surface of the foot.

Also Known As:

Extensor Plantar Response; Babinski Sign; Babinski's Sign; Reflex, Babinski; Babinski Reflexes; Babinski Sign Absent; Babinski Sign Negative; Babinski Sign Positive; Babinski's Reflex; Extensor Plantar Reflex; Great Toe Paradoxical Extensor Reflex; Reflexes, Babinski; Babinski Signs; Babinski's Signs; Extensor Plantar Responses; Plantar Reflex, Extensor; Plantar Response, Extensor; Plantar Responses, Extensor; Reflex, Babinski's; Reflex, Extensor Plantar; Response, Extensor Plantar; Responses, Extensor Plantar; Signs, Babinski's; Paradoxical Extensor Reflex, Great Toe

Networked: 23 relevant articles (2 outcomes, 1 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Parkinsonian Disorders (Parkinsonism)
2.	Spastic Paraparesis
3.	Abnormal Reflex (Hyperreflexia)
4.	Ataxia (Dyssynergia)
5.	Paraplegia (Spastic Paraplegia)

Experts

1.	Mathis, S: 1 article (09/2014)
2.	Cintas, P: 1 article (09/2014)
3.	Funalot, B: 1 article (09/2014)
4.	Magy, L: 1 article (09/2014)
5.	de Saint-Basile, G: 1 article (09/2014)
6.	Vallat, J-M: 1 article (09/2014)
7.	Valle, J: 1 article (01/2014)
8.	Sánchez, A: 1 article (01/2014)
9.	Lopera, E: 1 article (01/2014)
10.	Guillán, M: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Babinski Reflex:

1.	Levodopa (L Dopa)FDA LinkGeneric 01/01/1978 - "In some patients with parkinsonism, we have found and, often, cured by L-DOPA: 1) An unfrequent symptomatology (oculomotor, sensory, syncinesias, "Babinski" sign), not included in the classic rating scales. " 10/01/1994 - "The disappearance of the "spasticity," extensor plantar responses, and extrapyramidal signs, following levodopa therapy, confirmed the diagnosis of doparesponsive dystonia in these patients. "
2.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 03/01/1993 - "Three months after occlusion of the shunt vessel, fixation nystagmus and extensor plantar responses abolished and unsteadiness gait improved. "
3.	Spastic paraplegia 17IBA 09/01/2007 - "The clinical patterns in this family include presentation with lower-limb and hand-muscle involvement early in the disease course as well as the presence of Babinski signs with nonprogressive mild spastic paraparesis, resembling classic Silver syndrome and dHMN type V. This study reaffirms the clinical phenotype of the disorders associated with a BSCL2 Ser90Leu mutation and describes a genetically proven family with Silver syndrome and dHMN type V in Asia."
4.	Baclofen FDA LinkGeneric 07/01/1997 - "Spasticity, Babinski reflexes, clonus, strength, and coactivation of antagonist muscles during voluntary movement were decreased shortly after baclofen administration began. " 05/01/1992 - "Our results revealed that baclofen reduces spastically increased muscle tone and Babinski sign. "
5.	Sodium Chloride (Saline Solution)FDA LinkGeneric 07/01/1965 - "[Babinski's sign and sodium chloride]."
6.	Prednisolone (Predate)FDA LinkGeneric 10/01/2003 - "Acute-phase and demographic features including age, increased deep tendon reflexes, Babinski reflex, sex, preceding infection, decreased deep tendon reflexes, time course of peak neurologic impairment, treatment with prednisolone and/or high-dose methylprednisolone, and the day of illness when treatment was started were used as independent variables in a regression analysis. "
7.	PlasticsIBA 10/01/1987 - "Other neurological findings were as follows: upward gaze palsy, impaired convergence, convergence nystagmus, plastic rigidity of neck and all four limbs, and diffuse hyperreflexia with right Babinski's sign. "
8.	Parathyroid Hormone (Parathormone)IBA 05/01/1984 - "Two patients, one with ataxia, internuclear ophthalmoplegia, muscle weakness, atrophy, fasciculations, and bilateral Babinski's signs, the other with dysarthria, dysphagia, muscle weakness, atrophy, fasciculations, and hyperreflexia, had elevated serum calcium and parathyroid hormone levels, establishing the diagnosis of primary hyperparathyroidism (HPT). "
9.	Methylprednisolone FDA LinkGeneric 10/01/2003 - "Acute-phase and demographic features including age, increased deep tendon reflexes, Babinski reflex, sex, preceding infection, decreased deep tendon reflexes, time course of peak neurologic impairment, treatment with prednisolone and/or high-dose methylprednisolone, and the day of illness when treatment was started were used as independent variables in a regression analysis. "
10.	LipofuscinIBA 09/15/2014 - "We describe two sisters who presented the same phenotype of slowly progressive motor neuronopathy (with Babinski sign in one patient); biopsy of the sural nerve showed an abnormal endoneurial accumulation of lipofuscin granules. "

Therapies and Procedures

1.	Wheelchairs (Wheel Chair) 01/01/1989 - "The neurological features at the present are as follows; fine horizontal gaze-nystagmus, impaired smooth pursuit ocular movement, highly spastic paraplegia with pes equino-varus necessitating canes and the wheel-chair, highly accentuated PTRs and ATRs associated with positive Babinski's sign, diminished or absent deep reflexes in the upper extremities, moderate muscular wasting with fasciculation on the tongue and distal portions of the upper extremities (rt less than lt). "
2.	Transplantation (Transplant Recipients) 10/01/2010 - "In the absence of alterations in osmolality, they developed, between the second to seventh day after transplantation, a central quadriplegia, hyperreflexia and Babinski sign, with preservation of sensorium. "
3.	Artificial Respiration (Mechanical Ventilation) 07/01/2010 - "Focal motor deficits (OR = 12.78, 3.98-41.09) and Babinski sign (OR = 6.76, 2.24-20.33) on ICU admission, and duration of mechanical ventilation of 5 days or more (OR = 15.14, 2.92-78.52) were independent predictors of long-term sequels. "