Azetidines

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

1.	Neuralgia (Stump Neuralgia) 08/01/2010 - "A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. "
2.	Malaria 12/01/2021 - "The inhibition of Plasmodium cytosolic phenylalanine tRNA-synthetase (cFRS) by a novel series of bicyclic azetidines has shown the potential to prevent malaria transmission, provide prophylaxis, and offer single-dose cure in animal models of malaria. " 12/01/2021 - "Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines."
3.	Human Influenza (Influenza) 05/15/2006 - "Azetidines 5 and 6 were both markedly active against influenza A H2N2 virus, 10- to 20-fold more potent than amantadine. "
4.	Type 2 Diabetes Mellitus (MODY) 11/01/2005 - "Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. "
5.	Cryptosporidiosis 12/01/2020 - "Bicyclic azetidines treat cryptosporidiosis."

1.	T-Type Calcium Channels (T-Type Calcium Channel)
2.	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
3.	Pyrrolidines
4.	Phenylalanine (L-Phenylalanine)
5.	Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)
6.	Amides
7.	Amantadine (Aman)