Azetidinecarboxylic Acid

A proline analog that acts as a stoichiometric replacement of proline. It causes the production of abnormal proteins with impaired biological activity.

Also Known As:

3-azetidinecarboxylic Acid; Azetidine-2-carboxylic Acid; Azetidine-3-carboxylic Acid; 3 azetidinecarboxylic Acid; Azetidine 2 carboxylic Acid; Azetidine 3 carboxylic Acid; 2-Azetidinecarboxylic acid

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Rubenstein, Edward: 2 articles (01/2022 - 11/2008)
2.	Albertelli, Megan: 1 article (01/2022)
3.	Eaton, Mary Jane: 1 article (01/2022)
4.	Grimes, Kevin V: 1 article (01/2022)
5.	Hinojoza, Julian R: 1 article (01/2022)
6.	Sobel, Raymond A: 1 article (01/2022)
7.	Habashita, Hiromu: 1 article (01/2021)
8.	Hiraizumi, Kenji: 1 article (01/2021)
9.	Hoshino, Tomohiro: 1 article (01/2021)
10.	Inagaki, Yuichi: 1 article (01/2021)

Related Diseases

1.	Multiple Sclerosis 01/01/2022 - "Azetidine-2-Carboxylic Acid-Induced Oligodendrogliopathy: Relevance to the Pathogenesis of Multiple Sclerosis." 11/01/2008 - "Misincorporation of the proline analog azetidine-2-carboxylic acid in the pathogenesis of multiple sclerosis: a hypothesis." 01/01/2021 - "ONO-4641, 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid (ceralifimod), is a second-generation sphingosine 1-phosphate receptor agonist selective for sphingosine 1-phosphate receptors 1 and 5, and has clinical effects in multiple sclerosis. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/1999 - "Effects of azetidine-2-carboxylic acid on treatments of hepatoma cells with single or fractionated X-ray irradiations and on thermal radiosensitization in normal and thermotolerant cells." 09/01/1978 - "3. Labile protein was produced in hepatoma cells incubated in the presence of azetidine-2-carboxylic acid, canavanine, indospicine, triazolalanine, 2-, 3- and 4-fluorophenylalanine. "
3.	Neoplasms (Cancer) 12/01/1989 - "However we identified three compounds that inhibited tumor-cell attachment in a reversible fashion: (1) a specific inhibitor of collagen deposition (L-azetidine-2-carboxylic acid); (2) a bacterial neutral protease (Dispase); and (3) synthetic fibronectin peptides that contained the arginine-glycine-asparate (RGD) sequence that is responsible for cell binding. "
4.	Granuloma 01/01/1974 - "The effect of azetidine-2-carboxylic acid on the biosynthesis of collagen in rat granuloma."
5.	Autoimmune Diseases (Autoimmune Disease) 07/16/2012 - "1-{4-[(4-Phenyl-5-trifluoromethyl-2-thienyl)methoxy]benzyl}azetidine-3-carboxylic acid (MRL-A) is a potent sphingosine-1-phosphate-1 receptor agonist, with potential application as an immunosuppressant in organ transplantation or for the treatment of autoimmune diseases. "

Related Drugs and Biologics

1.	Proline (L-Proline)
2.	Peptides (Polypeptides)
3.	Collagen
4.	Hypoxia-Inducible Factor-Proline Dioxygenases
5.	Transcription Factors (Transcription Factor)
6.	Proteins (Proteins, Gene)
7.	p-Fluorophenylalanine
8.	Ketoglutaric Acids (Ketoglutaric Acid)
9.	Immunosuppressive Agents (Immunosuppressants)
10.	Glycine (Aminoacetic Acid)

Related Therapies and Procedures

1.	Organ Transplantation