Azaserine

Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.

Also Known As:

Networked: 151 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Marchase, Richard B: 3 articles (01/2007 - 12/2002)
2.	Kalipci, E: 2 articles (05/2013 - 01/2013)
3.	Chatham, John C: 2 articles (01/2007 - 04/2004)
4.	Bounelis, Pam: 2 articles (04/2004 - 12/2002)
5.	Pang, Yi: 2 articles (04/2004 - 12/2002)
6.	Nagy, Krisztina: 2 articles (11/2003 - 05/2003)
7.	Réz, Gábor: 2 articles (11/2003 - 05/2003)
8.	Pálfia, Zsolt: 2 articles (11/2003 - 05/2003)
9.	Réz, G: 2 articles (01/2001 - 01/2001)
10.	Nagy, K: 2 articles (01/2001 - 01/2001)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/1992 - "Retinamides have a modest chemopreventive effect against pancreatic cancer in rats dosed with azaserine; these compounds are reported both to increase and to decrease the incidence of pancreatic cancer in hamsters. " 08/01/1990 - "In the rat, when pancreatic growth is stimulated there is an increased incidence of spontaneous pancreatic neoplasms and marked potentiation of the pancreatic carcinogen azaserine. " 01/01/1990 - "We also investigated proto-oncogene expression associated with the progression of pancreatic cancers in azaserine-treated rats. " 12/01/1987 - "Growth of pancreatic foci and development of pancreatic cancer with a single dose of azaserine in the rat." 05/01/1987 - "Previous reports have shown that pancreatic cancer was induced preferentially in male versus female azaserine-treated rats. "
2.	Carcinoma (Carcinomatosis) 01/01/2007 - "Previous studies have shown that, cultured rat pancreatic carcinoma cells, derived from azaserine-induced acinar tumours, yield tumours with a ductal phenotype. " 02/01/2000 - "In the present study we investigated rat pancreatic tumour growth after intrapancreatic injection of cultured pancreatic carcinoma cells (DSL-6A/C1), originally derived from an azaserine-induced tumour, as well as the features of tumour microcirculation using the microangiography technique. " 01/01/1990 - "Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats." 11/01/1987 - "The growth of azaserine-induced foci and nodules in a 4-month experiment and the incidence of carcinomas in a 15-month experiment were greater in LEW/CrlBR inbred rats fed a purified diet (AIN-76A) than in rats fed a natural-ingredient diet (chow). " 01/01/1982 - "The incidence of pancreatic carcinoma among a male positive control group (azaserine treated, but not retinoid treated) was 42%. "
3.	Acinar Cell Carcinoma 11/01/1996 - "At 18 months of age, one azaserine-treated animal developed a pancreatic acinar cell carcinoma, which likewise exhibited significantly greater CCK binding than internodular pancreas or normal pancreas (p < 0.001 for both). " 11/01/1996 - "These findings demonstrate increased CCK binding in azaserine-induced preneoplastic pancreatic nodules and pancreatic acinar cell carcinoma, compatible with our previous demonstration of receptor overexpression in these tissues. " 08/01/1990 - "Similar hormonal treatments have also influenced the growth of an azaserine-induced poorly differentiated acinar cell carcinoma that can be transplanted syngeneically in Lewis rats. " 01/01/1986 - "Acinar cells were isolated by enzymatic digestion from normal pancreas and from azaserine-induced atypical acinar cell nodules and a transplantable acinar cell carcinoma. " 07/01/1983 - "The earliest morphological evidence of altered growth potential of pancreatic acinar cells of the rats treated with carcinogen, such as azaserine, is the development of nodules of atypical acinar cells, some of which are considered to appear, eventually, as acinar cell carcinomas. "
4.	Hyperglycemia 03/01/2009 - "We investigated whether the HBP inhibitor azaserine protects against hyperglycemia-induced endothelial damage dependently of HBP. " 12/01/2002 - "The attenuation of CCE by hyperglycemia was prevented by azaserine, an inhibitor of hexosamine biosynthesis, and partially by inhibitors of oxidative stress. " 01/01/2007 - "The improved survival with hyperglycemia was attenuated by azaserine, which inhibits glucose metabolism via the hexosamine biosynthesis pathway. " 04/01/2004 - "The attenuation of CCE was also seen with glucosamine, and the inhibition by hyperglycemia was prevented by azaserine, thereby implicating hexosamine biosynthesis as the responsible metabolic pathway. " 04/01/2004 - "The inhibition by hyperglycemia of phenylephrine-induced inotropy was reversed with azaserine and mimicked by glucosamine. "
5.	Neoplasms (Cancer) 03/01/2000 - "We have examined the role of p48 in the phenotype of azaserine-induced rat DSL6 tumors and cancers of the human exocrine pancreas. " 03/01/1998 - "Azaserine-induced rat pancreas tumor model with transplantable cultured cells." 01/01/1997 - "It was concluded that dietary GOS has no modulating effect on pancreatic carcinogenesis in azaserine-treated rats or on the tumor-promoting effect of a high-fat diet." 04/15/1996 - "To test this hypothesis, we have determined the role of this region on the constitutive ODC hyperexpression measured in AR4-2J cells, an azaserine-induced, tumor-derived pancreatic acinar cell line. " 07/01/1991 - "Secretagogue response of azaserine-induced rat pancreatic acinar tumors in vivo."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Retinoids
3.	Melphalan (Alkeran)
4.	Cholecystokinin B Receptor
5.	Cholecystokinin Receptors (Cholecystokinin Receptor)
6.	Gastrins
7.	6-Mercaptopurine (Mercaptopurine)
8.	Cholecystokinin (Pancreozymin)
9.	Messenger RNA (mRNA)
10.	Testosterone (Sustanon)

Related Therapies and Procedures

1.	Injections
2.	Pancreatectomy
3.	Intraperitoneal Injections
4.	Chemoprevention
5.	Gastric Bypass (Roux-en-Y Gastric Bypass)