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Autonomic Nervous System Diseases (Dysautonomia)

Diseases of the AUTONOMIC NERVOUS SYSTEM, including sympathetic, parasympathetic, and enteric nervous systems.
Also Known As:
Dysautonomia; Disorders of the Autonomic Nervous System; ANS (Autonomic Nervous System) Diseases; ANS Diseases; Autonomic Central Nervous System Diseases; Autonomic Diseases; Autonomic Nervous System Disorders; Autonomic Peripheral Nervous System Diseases; Segmental Autonomic Dysfunction; ANS Disease; Autonomic Disease; Autonomic Disorder; Autonomic Dysfunction, Segmental; Autonomic Dysfunctions, Segmental; Disorder, Autonomic; Dysautonomia, Non-Familial; Dysautonomias; Non Familial Dysautonomia; Non-Familial Dysautonomias; Segmental Autonomic Dysfunctions; Autonomic Disorders; Central Autonomic Nervous System Diseases; Nervous System Diseases, Autonomic; Nervous System Diseases, Parasympathetic; Nervous System Diseases, Sympathetic; Non-Familial Dysautonomia; Parasympathetic Nervous System Diseases; Peripheral Autonomic Nervous System Diseases; Sympathetic Nervous System Diseases
Networked: 722 relevant articles (38 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Hypovolemia
3. Orthostatic Hypotension (Postural Hypotension)
4. Disease Progression
5. Orthostatic Intolerance

Experts

1. Vernino, Steven: 11 articles (12/2021 - 06/2003)
2. Goldstein, David S: 8 articles (01/2020 - 06/2003)
3. Low, Phillip A: 7 articles (01/2020 - 06/2003)
4. Nakane, Shunya: 6 articles (01/2022 - 02/2020)
5. Cheshire, William P: 5 articles (01/2022 - 01/2018)
6. Higuchi, Osamu: 5 articles (01/2022 - 02/2020)
7. Mukaino, Akihiro: 5 articles (01/2022 - 02/2020)
8. Kaufmann, Horacio: 5 articles (12/2020 - 03/2008)
9. Emborg, Marina E: 5 articles (01/2020 - 01/2012)
10. Biaggioni, Italo: 4 articles (01/2020 - 07/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Autonomic Nervous System Diseases:
1. Norepinephrine (Noradrenaline)FDA LinkGeneric
2. Intravenous Immunoglobulins (IVIG)FDA Link
3. DroxidopaIBA
05/12/2017 - "Droxidopa is effective for the treatment of nOH in patients with primary autonomic disorders and is generally well-tolerated. "
03/01/2008 - "This mechanism of action makes droxidopa effective in patients with central and peripheral autonomic disorders."
05/12/2017 - "Droxidopa, a prodrug of norepinephrine, was approved for treatment of neurogenic orthostatic hypotension (nOH) due to primary autonomic disorders based on 3 randomized double-blind studies. "
03/01/2008 - "In double blind, cross over, placebo controlled trials, administration of droxidopa, a synthetic amino acid that is decarboxylated to norepinephrine by the enzyme L: -aromatic amino acid decarboxylase increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability in patients with neurogenic orthostatic hypotension due to degenerative autonomic disorders. "
12/01/2009 - "The following therapeutic strategies are frequently used in the treatment of PD-related dysautonomia: 1. Orthostatic hypotension: fludrocortisone, midodrine, and droxidopa; 2. Sialorrhea: glycopyrrolate and botulinun toxin injections; 3. Constipation: symbiotic yogurt and bulking agents, macrogol, lubiprostone, mosapride citrate and tegaserod, pyridostigmine bromide, botulinum toxin injections and sacral nerve stimulation; 4. Urinary frequency: oxybutynin, tolterodine, solifenacin, darifenacin, botulinum toxin injections; 5. Erectile dysfunction: sildenafil and other phosphodiesterase type 5 inhibitors. "
4. BaclofenFDA LinkGeneric
5. ReninIBA
6. Botulinum Toxins (Botulinum Toxin)IBA
7. Epinephrine (Adrenaline)FDA LinkGeneric
8. EnzymesIBA
9. Amino AcidsFDA Link
10. Immune Checkpoint InhibitorsIBA

Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Length of Stay
4. Artificial Respiration (Mechanical Ventilation)
5. Vascular Surgical Procedures