Autoimmune Diseases (Autoimmune Disease)

07/23/2011 - "Although antigen-based therapy is a highly desirable treatment and is effective in animal models, translation to human autoimmune disease remains a challenge. "
11/01/2013 - "Given its promise for the manipulation of self-reactive polyclonal T cells demonstrated here, the distinctive characteristics of this antigen delivery system will be important to appreciate as its potential as an intervention for autoimmune diseases continues to be investigated."
04/01/2005 - "Once a better understanding of the normal processes and aberrancies that lead to disease are had, one can look forward to interventions to reestablish tolerance, perhaps by something as simple as a capsule containing the appropriate self antigen-containing molecules--"oral tolerizing" as a cure for autoimmune diseases! There is much promising evidence in favor of the efficacy of oral tolerance in animal models, but as of yet, human disease has proven a harder nut to crack. "
11/17/1998 - "A combination of oral antigen feeding and administration of anti-IL-12 may thus be useful in the treatment of autoimmune diseases and may be a potent means to modulate peripheral tolerance."
06/01/1995 - "A statistical analysis of autoantibody repertoires has important possible applications: it detects spontaneous or therapeutically induced changes of repertoires, it identifies regions of interest, it supports the isolation of relevant antigens, and it will also be helpful in the diagnosis of autoimmune diseases."

11/01/2014 - "Rituximab (RTX), an anti-CD20 monoclonal antibody, is highly effective in the treatment of several autoimmune diseases. "
05/01/2005 - "Current data obtained from studies of rituximab single-agent therapy for autoimmune disease show good tolerability and sustained improvement in disease symptoms, although the precise mechanisms of action in autoimmunity remain to be fully clarified. "
04/01/2007 - "Rituximab appears to be beneficial for patients with refractory autoimmune diseases and may reduce corticosteroid exposure. "
02/01/2011 - "Monthly to bi-monthly rituximab infusion dosing may be a more appropriate dosing strategy for autoimmune disease that minimizes potential side effects while generating remission of disease. "
01/01/2015 - "Recently, rituximab (RTX), a B cell-targeted therapy, has been reported to be effective for life-threatening autoimmune diseases. "

12/01/2014 - "Data from meta-analyses of heterogeneous placebo-controlled trials indicate that IVIg may be effective in secondary RM, but most trials to date have used immunomodulatory doses lower than those considered to be efficient in autoimmune disease. "
06/01/2005 - "The efficacy of IVIG has been established only in several autoimmune diseases; clinical reports of trials, series, and case reports indicate significant improvement in many more autoimmune diseases. "
12/01/1993 - "Results from the present study suggest a novel mechanism by which IVIg may be beneficial in human autoimmune diseases."
01/01/1999 - "Intravenous immunoglobulins (IVIg) therapy has been reported to be beneficial in a large number of autoantibody-mediated or self-reactive T cells-associated autoimmune diseases. "
10/01/1998 - "High dose intravenous immunoglobulins (IVIG) have been shown to be effective in different autoimmune diseases. "

08/01/2013 - "Many autoimmune diseases are associated with a particular set of autoantibodies, which have emerged as highly useful to define and classify disease, predict flares, or monitor efficacy of therapy. "
07/01/2012 - "Autoantibodies may be helpful for the diagnosis of autoimmune diseases, but regular and long follow-up is needed in NHL patients with high levels of autoantibodies."
06/01/2009 - "Due to the overlap in autoantibody profiles in autoimmune diseases, and due to the complexity of MS, multiplex autoantibody profiling approaches are needed to generate a panel of MS-associated autoantibodies with high combined sensitivity and specificity for MS. In recent years, several multiplexing approaches have been applied in MS autoantibody profiling with promising results regarding the generation of a so-called MS-specific autoantibody fingerprint. "
03/01/1997 - "These findings suggest that LBZ may be effective in the treatment of other autoimmune diseases such as lupus erythematosus that are also characterized by the production of autoantibodies from activated B cells. "
08/01/2010 - "Therapy approaches based on lowering levels of pathogenic autoantibodies represent rational, effective, and safe treatment modalities of autoimmune diseases. "

01/01/2008 - "Recent clinical trials have shown that depleting B cells can be highly beneficial for patients with autoimmune diseases, implicating B cells and antibodies as key drivers of pathology. "
04/01/2014 - "CD20-specific antibodies show remarkable therapeutic efficacy in B-cell malignancy and autoimmune diseases, but due to the occurrence of a significant treatment resistance, a critical, unmet need for improving B-cell-depleting approaches remains. "
10/01/2009 - "Laboratory tests for detection of antibodies against the heart are very helpful in diagnosing and monitoring cardiac autoimmune diseases, but the prevalence of anti-heart antibodies varies a lot between the tests. "
03/17/2009 - "These results have important implications for the development of improved antibodies and new therapeutic strategies for the treatment of autoimmune diseases."
12/01/2010 - "We evaluated the embryolethality and embryotoxicity of sera from patients suffering from autoimmune diseases during remission on post-implantation rat embryos cultured on these sera and determined the association between the patients' clinical history, high blood levels of specific antibodies, medications, and oxidative stress parameters. "

02/01/1998 - "Effective treatment of autoimmune diseases with extremely low dose cyclosporine."
08/01/1990 - "As a result of these observations, cyclosporin A, a drug with proven efficacy in autoimmune diseases and bone marrow insufficiency, is being used in these cases. "
03/26/1999 - "Several clinical studies have shown that cyclosporin A (CsA) is effective for treating a variety of chronic inflammatory and autoimmune diseases. "
05/01/1986 - "This study supports the possibility that treatment with cyclosporin and (Nva2)-cyclosporin might be effective in the treatment of certain autoimmune diseases in man."
02/01/1996 - "Chronic cyclosporine therapy, started at an early age, is effective in controlling the autoimmune disease in MRL/lpr mice, including the ocular and lacrimal gland lesions."

04/01/2012 - "Long-term therapy with intravenous immunoglobulin is beneficial in patients with autoimmune diseases."
01/01/2010 - "Intravenous immunoglobulin is beneficial in other autoimmune diseases. "
01/01/2006 - "Intravenous immunoglobulin is beneficial in other autoimmune diseases. "
01/01/2004 - "Intravenous immunoglobulin purified from donated blood is beneficial in other autoimmune diseases. "
01/01/2001 - "Intravenous immunoglobulin purified from donated blood is beneficial in other autoimmune diseases and is easier to administer. "

09/01/2002 - "These observations suggest that HE2500 and/or HE2200 limit the production of autoimmune Th1 associated cytokines, and ultimately may be beneficial for patients with MS or other autoimmune diseases."
12/01/2011 - "Inhibition of PARP-1 enzymatic activity reduces the secretion of pro-inflammatory cytokines and ameliorates autoimmune diseases in several experimental models. "
09/06/2010 - "Type 1 autoimmune diseases are improved when decrease type 1 cytokines (i.e. "
11/28/2007 - "In response to stimuli, this subset of cells rapidly produces large amounts of cytokines thereby provoking immune responses, including protection against autoimmune diseases. "
03/01/2004 - "Because of the pathogenic role of cytokines, cytokine antagonists, currently evaluated in other autoimmune diseases, have been tested with positive results also in a small series of GO patients. "

08/01/1989 - "Our results indicate that at least some forms of autoimmune disease may be effectively treated by thus reducing the concentration of IgG autoantibody in this manner."
03/01/1983 - "The clearance of erythrocytes sensitized with IgG was studied in MRL/Mp-lpr/lpr (MRL-lpr) and MRL/Mp-+/+ (MRL-+/+) mice, which spontaneously develop autoimmune disease. "
05/01/2014 - "Finally, based on our preliminary analysis in this study, we propose that low IgG antibody responses to potential pathogenic environmental factors may be the fundamental disorder in autoimmune diseases. "
01/01/2013 - "To study IgG RFs in patients with other autoimmune diseases, phage display antibody libraries from a hepatitis C virus infected patient with Sjögren's syndrome were constructed. "
11/25/2011 - "Taken together, our study suggests a molecular mechanism for the high affinity IgG recognition by FcγRI and provides a structural basis for understanding its physiological function and its therapeutic implication in treating autoimmune diseases."

03/01/1983 - "These results suggest that the beneficial effects of androgen on autoimmune disease are not due solely to improved clearance of immune complexes. "
02/01/1981 - "In order to understand better the role of immune complex metabolism in the pathogenesis of autoimmune diseases, we have investigated the early stages of immune complex uptake by the liver, the major organ responsible for clearance of soluble complexes in the mouse. "
07/01/2006 - "Recent studies have demonstrated that the defect in the clearance of immune complexes and apoptotic cells is associated with autoimmune disease. "
07/01/2012 - "Genetic deficiency of any early component of the classical pathway (C1q, C1r/s, C2, C4, and C3) is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response. "
05/15/2012 - "This meta-analysis implicates the clearance of immune complex in the etiology of non-organ-specific autoimmune disease."

10/01/1995 - "In vivo, agents that block CD28-mediated costimulation have proved extremely effective in inhibiting the immune response in experimental models of transplantation and autoimmune disease, providing novel strategies for use in clinical trials in the near future."
02/27/2008 - "While all trials performed during the inflammatory stage of autoimmune disease suggested that transplantation of HSCs may have a potent disease-remitting effect, remission duration remains unclear, and no randomized trials have been published. "
06/07/2008 - "For autoimmune diseases, transplantation is associated with significant improvement in the quality and length of life. "
05/15/1999 - "Docosahexaenoic acid (DHA) has been shown to be immunosuppressive in the fetus, and fish oil diets are thought to be beneficial in autoimmune disease and transplantation. "
05/01/1997 - "Allogeneic marrow transplantation may be effective for the control of autoimmune diseases like SSc because the preparative regimen will significantly suppress the host immune system and the antihost effects of the donor immune system in the engrafted marrow will help maintain the suppression of the host immune system. "

10/01/1990 - "Inter-T cell TCR-ABCMC may be particularly effective in inflammatory tissues, such as rejecting allografts and autoimmune diseases, in which numerous cytolytic T lymphocytes are present in close association with other T cells."
07/01/1998 - "This fusion protein could prove useful in the treatment of allograft rejections and autoimmune diseases."
01/01/2014 - "Increasing evidence supports the efficacy of this approach in pre-clinical models of autoimmune disease and allograft rejection. "
01/01/2010 - "This review would provide an overview of some patents along with the role of JAK3 in the immune system and efficacy of JAK3 inhibitors in experimental allograft rejection and autoimmune disease."
09/18/1999 - "EXPERIMENTAL BASIS AND CLINICAL OBSERVATIONS: Remission of an autoimmune disease has been observed in certain patients after bone marrow allograft from a healthy donor. "

10/01/2008 - "Therefore, immunotherapy approaches that aim to restore or expand autoantigen-specific Treg activity might be beneficial for the treatment of autoimmune disease. "
04/01/2014 - "Peptide immunotherapy may be effective for ameliorating some allergic and autoimmune diseases. "
03/15/1999 - "These results suggest that the development of immunotherapies that target the IL-12Rbeta2 subunit may be useful for the treatment of autoimmune diseases."
12/01/1993 - "Experiments in animal models, in combination with a number of clinical trials completed in the last year, have helped to clarify the pathogenesis of various autoimmune diseases and indicate future strategies for immunotherapy."
06/15/2015 - "Foxp3(+) regulatory T cell (Treg)-based immunotherapy holds promise for autoimmune diseases. "

10/01/2012 - "This mechanism of action has to be taken into account in clinical trials, where it should be beneficial in grafts and autoimmune diseases, but potentially detrimental in malignant diseases."
03/01/2009 - "The different effects of ASA on CD4(+)CD25(+)Foxp3(+) Treg cells and CD4(+)CD25(-) T cells may potentially make hosts susceptible to tolerance induction which would be beneficial for tolerance induction in patients with autoimmune diseases or allo-grafts. "
02/26/2005 - "THE CONCEPT OF RESTORING NORMAL IMMUNE REACTIVITY must in part br true since current results of 466 transplants (445 autologous, 21 allogeneic) patients suffering from various autoimmune diseases show a beneficial outcome in approximately 2/3 of the patients. "
02/01/2008 - "Therapy with anti-CD3 antibody is effective in controlling models of autoimmune diseases and can reverse or prevent rejection of grafts. "
12/27/1995 - "Our results confirm that 700 J/m2 UV-B irradiation of BM cells combined with CsA recipient immunosuppression impairs the recovery capacity of stem cells while the use of lower UV-B (100-200 J/m2) is effective in preventing CsA-induced autoimmune disease without endangering BM engraftment and leads to induction of transplant tolerance."

01/01/1986 - "The present findings demonstrate that MX is a potent immunosuppressive agent and as such might prove to be clinically useful in the treatment of autoimmune diseases or find utility in the organ transplantation field."
01/01/2004 - "Immunosuppressive drugs have revolutionized organ transplantation and improved the therapeutic management of autoimmune diseases. "
02/01/1987 - "New information about established immunosuppressive drugs and the introduction of new drugs are providing new opportunities for effective treatment of autoimmune diseases and improved effectiveness of organ transplantation. "
05/01/2002 - "Pharmacogenomics holds many promises for improved treatment of a large variety of medical conditions, including immunosuppression for organ transplantation and autoimmune disease. "
08/01/2015 - "The review will comment on recent genomewide association studies (GWAS) and discuss their relevance in this field, and it will also comment on recent meta-analysis combining GWAS studies with other studies such as gene expression micro array data in the field of autoimmune disease and solid organ transplantation. "